Structure-activity relationship studies of phenanthridine-based Bcl-X L inhibitors

Journal of Medicinal Chemistry

Volumn 51, Issue 21, 2008, Pages 6699-6710

  Bernardo, Paul H ^a   Wan, Kah Fei ^b   Sivaraman, Thirunavukkarasu ^c   Xu, Jin ^a   Moore, Felicity K ^a   Hung, Alvin W ^a   Mok, Henry Y K ^c   Yu, Victor C ^b   Chai, Christina L L ^a  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

(4 AMINOPHENYL)ETHYL TERT BUTYLDIMETHYLSILYL ETHER; (4 AMINOPHENYL)METHYL TERT BUTYLDIMETHYLSILYL ETHER; 2 (TERT BUTYLDIMETHYLSILOXYETHYL) 7,8 DIMETHOXY 5 (METHOXYMETHYL)PHENANTHRIDIN 6(5H) ONE; 2 BROMO 5,6 DIMETHOXYBENZALDEHYDE; 2 BROMO 5,6 DIMETHOXYBENZOIC ACID; 2 BROMO N [4 (TERT BUTYLDIMETHYLSILOXYMETHYL)PHENYL] 5,6 DIMETHOXYBENZAMIDE; 2 BROMO N [4 (TERT BUTYLDIMETHYLSILOXYMETHYL)PHENYL] N (METHOXYMETHYL) 5,6 DIMETHOXYBENZAMIDE; 2,2 DIMETHYL[1,3]DIOXOLO 5 METHYL [4,5 I]PHENANTHRIDINE; 2,2 DIMETHYL[1,3]DIOXOLO[4,5 I]PHENANTHRIDINE; 2,2 DIMETHYL[1,3]DIOXOLO[4,5 I]PHENANTHRIDINE 5 OXIDE; 5 BROMO 2,2 DIMETHYLBENZO[D][1,3]DIOXOLE 4 CARABALDEHYDE; 5 BROMO N [4 (2 TERT BUTYLDIMETHYLSILOXYETHYL)PHENYL] N (METHOXYMETHYL)BENZO[D][1,3]DIOXOLE 4 CARBOXAMIDE; 5 BROMO N [4 (2 TERT BUTYLDIMETHYLSILOXYETHYL)PHENYL]BENZO[D][1,3]DIOXOLE 4 CARBOXAMIDE; 5 BROMO N [4 (TERT BUTYLDIMETHYLSILOXYMETHYL)PHENYL] N (METHOXYMETHYL)BENZO[D][1,3]DIOXOLE 4 CARBOXAMIDE; 5 BROMO N [4 (TERT BUTYLDIMETHYLSILOXYMETHYL)PHENYL]BENZO[D][1,3]DIOXOLE 4 CARBOXAMIDE; 5 BROMOBENZO[D][1,3]DIOXOLE 4 CARBALDEHYDE; 5 BROMOBENZO[D][1,3]DIOXOLE 4 CARBOXYLIC ACID; 7,8 DIMETHOXY 5 METHYLPHENANTHRIDINIUM IODIDE; 7,8 DIMETHOXYPHENANTHRIDINE; 8 (TERT BUTYLDIMETHYLSILOXYMETHYL) 5 (METHOXYMETHYL)[1,3]DIOXOLO[4,5 I]PHENANTHRIDIN 4(5H) ONE; [1,3]DIOXOLO[4,5 I]PHENANTHRIDINE 5 OXIDE; [1,3]DIOXOLOL[4,5 I]PHENANTHRIDINE; BH3 PROTEIN; CHELERYTHRINE; PHENANTHRIDINE DERIVATIVE; PROTEIN BAK; PROTEIN BCL XL; PROTEIN INHIBITOR; SANGUINARINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CYCLIZATION; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TRANSFORMATION; FLUORESCENCE POLARIZATION; GENE DISRUPTION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; IC 50; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

BCL-X PROTEIN; COMPUTER SIMULATION; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PHENANTHRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56249103832     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8005433     Document Type: Article

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