ER-targeted Bcl-2 and inhibition of ER-associated caspase-12 rescue cultured immortalized cells from ethanol toxicity

Alcohol

Volumn 44, Issue 6, 2010, Pages 553-563

  Balan, Andreea G ^a   Myers, Barret J ^a   Maganti, Jansi L ^a   Moore, D Blaine ^a  

^a KALAMAZOO COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 12; CASPASE 9; COMPLEMENTARY DNA; PROTEIN BCL 2;

ALCOHOL INTOXICATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL CULTURE; CELL IMMORTALIZATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; GENE CONSTRUCT; GENETIC TRANSFECTION; MITOCHONDRION; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; WILD TYPE;

ANIMALS; CASPASE 12; CELL LINE, TRANSFORMED; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; ETHANOL; GENES, BCL-2; GREEN FLUORESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

CRICETULUS GRISEUS;

EID: 77956643920     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2010.07.003     Document Type: Article

References (52)

1. Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., Akey C.W. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell 2002, 9:423-432.
2. Antonsson B., Montessuit S., Lauper S., Eskes R., Martinou J.C. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem. J. 2000, 345:271-278.
3. Bassik M.C., Scorrano L., Oakes S.A., Pozzan T., Korsmeyer S.J. Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J 2004, 23:1207-1216.
4. Bitko V., Barik S. An endoplasmic reticulum-specific stress-activated caspase (caspase-12) is implicated in the apoptosis of A549 epithelial cells by respiratory syncytial virus. J. Cell. Biochem. 2001, 80:441-454.
5. Chen G., Ma C., Bower K.A., Shi X., Ke Z., Luo J. Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress. J. Neurosci. Res. 2008, 86:937-946.
6. Chen S.H., Liang Y.C., Chao J.C., Tsai L.H., Chang C.C., Wang C.C., et al. Protective effects of ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. World J. Gatroenterol. 2005, 11:3746-3750.
7. Diaz-Horta O., Kamagate A., Herchuelz A., Van Eylen F. Na/Ca Exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells. Diabetes 2002, 51:1815-1824.
8. Dlugos C.A. Ethanol-related smooth endoplasmic reticulum dilation in Purkinje dendrites of aging rats. Alcohol. Clin. Exp. Res. 2006, 30:883-891.
9. Drenan R.M., Liu X., Beretram P.G., Zheng X.F.S. FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus. J. Biol. Chem. 2004, 279:772-778.
10. Dunty W.C., Chen S.-Y., Zucker R.M., Dehart D.B., Sulik K.K. Selective vulnerability of embryonic cell populations to ethanol-induced apoptosis: implications of alcohol-related birth defects and neurodevelopment disorder. Alcohol. Clin. Exp. Res. 2006, 25:1523-1535.
11. Esfandiari F., Villanueva J.A., Wong D.H., French S.W., Halsted C.H. Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289:G54-G63.
12. Heath-Engel H.M., Chang N.C., Shore G.C. The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family. Oncongen 2008, 27:6419-6433.
13. Heaton M.B., Moore D.B., Paiva M., Gibbs T., Bernard O. Bcl-2 overexpression protects the neonatal cerebellum from ethanol neurotoxicity. Brain Res. 1999, 817:13-18.
14. Hetz C.A. ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. Antioxid. Redox. Signal. 2007, 9:2345-2355.
15. Higuchi H., Kurose I., Kato S., Miura S., Ishii H. Ethanol-induced apoptosis and oxidative stress in hepatocytes. Alcohol. Clin. Exp. Res. 2006, 20:340A-346A.
16. Holt S.E., Glinsey V.V., Ivanova A.B., Glinsky G.V. Resistance to apoptosis in human cells conferred with telomerase function and telomerase activity. Mol. Carcinog. 1999, 25:241-248.
17. Ikonomidou C., Bittigau P., Ishimaru M.J., Wozniak D.F., Koch C., Genz K., et al. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 2000, 287:1056-1060.
18. Inoue M., Nakamura K., Iwahashi K., Ameno K., Itoh M., Suwaki H. Changes of Bcl-2 and Bax mRNA expressions in the ethanol-treated mouse brain. Nihon Arukoru Yakubutsu Igakkai Zasshi 2002, 37:120-129.
19. Ji C., Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003, 124:1488-1499.
20. Jo M., Kim T.-H., Seol D.-W., Esplen J.E., Dorko K., Billiar T.R., et al. Apoptosis induced in normal human hepatocytes by tumor necrosis-related apoptosis-inducing ligand. Nat. Med. 2000, 6:564-567.
21. Jung M.E., Wilson A.M., Simpkins J.W. A nonfeminizing estrogen analog protects against ethanol withdrawal toxicity in immortalized hippocampal cells. J. Pharmacol. Exp. Ther. 2006, 319:543-550.
22. Karten B., Maclnnis B.L., Eng H., Azumaya Y., Martin G., Lund K., et al. Analytical approaches for investigating apoptosis and other biochemical events in compartmentalized cultures of sympathetic neurons. Apoptosis Techniques and Protocols 2002, 163-175. Humana Press, New Jersey. A.C. LeBlanc (Ed.).
23. Kroemer G., Martin S.J. Caspase-independent cell death. Nat. Med. 2005, 11:725-730.
24. Lao Y., Chang D.C. Mobilization of Ca2+ from endoplasmic reticulum to mitochondria plays a positive role in the early stage of UV- or TNFalpha-induced apoptosis. Biochem. Biophys. Res. Commun. 2008, 373:42-47.
25. Lithgow T., van Driel R., Bertram J.F., Strasser A. The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ. 1994, 5:411-417.
26. Liu J., Tian Z., Gao B., Kunos G. Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine. J. Biol. Chem. 2002, 277:20927-20933.
27. Liu E.S.L., Cho C.H. Relationship between ethanol-induced gastritis and gastric ulcer formation in rats. Digestion 2000, 62:232-239.
28. Liu X., Kim C.N., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996, 86:147-157.
29. Lobner D. Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis?. J. Neurosci. Methods 2000, 96:147-152.
30. Lockshin R.A., Zakeri Z. Caspase-independent cell deaths. Curr. Opin. Cell Biol. 2002, 14:727-733.
31. Moore D.B., Walker D.W., Heaton M.B. Neonatal ethanol exposure alters bcl-2 family mRNA levels in the rat cerebellar vermis. Alcohol. Clin. Exp. Res. 1999, 23:1251-1261.
32. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 2000, 403:98-103.
33. A receptor activation induces cell death in developing rat hippocampus. Exp. Neurol. 2003, 181:258-269.
34. Nurmi K., Methuen T., Maki T., Lindstedt K.A., Kovanen P.T., Sandler C., et al. Ethanol induces apoptosis in human mast cells. Life Sci. 2009, 85:678-684.
35. Oakes S.A., Opferman J.T., Pozzan T., Korsmeyer S.J., Scorrano L. Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem. Pharmacol. 2003, 66:1335-1340.
36. Orrenius S., Zhivotovsky B., Nicotera P. Regulation of Cell Death: The calcium-apoptosis link. Nat. Rev. Mol. Cell Biol. 2003, 4:552-565.
37. Reed J.C., Jurgensmeier J.M., Matsuyama S. Bcl-2 family proteins and mitochondria. Biochim. Biophys. Acta Bioenerg. 1998, 1(266):127-137.
38. Rodriguez J., Lazebnik Y. Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev. 1999, 13:3179-3184.
39. Skovronsky D.M., Moore D.B., Milla M.E., Doms R.W., Lee V.M.-Y. Protein kinase C-dependent α-secretase competes with β-secretase for cleavage of amyloid-β precursor protein in the trans-Golgi network. J. Biol. Chem. 2000, 275:2568-2575.
40. Srinivasula S.M., Ahmad M., Fernandes-Alnemri T., Alnemri E.S. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell 1998, 1:949-957.
41. Szegezdi E., Logue S.E., Gorman A.M., Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 2006, 7:880-885.
42. Tan F.J., Husain M., Manlandro C.M., Koppendol M., Fire A.Z., Hill R.B. CED-9 and mitochondrial homeostasis in C. elegans muscle. J. Cell Sci. 2008, 121:3373-3382.
43. Thomenius M.J., Wang N.S., Reineks E.Z., Wang Z., Distelhorst C.W. Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins. J. Biol. Chem. 2003, 278:6243-6250.
44. Vaudry D., Rousselle C., Basille M., Falluel-Morel A., Pamantung T.F., Fontaine M., et al. Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. Proc. Natl. Acad. Sci. U S A 2002, 99:6398-6403.
45. Venugopal S.K., Chen J., Zhang Y., Clemens D., Follenzi A., Zern M.A. Role of apoptosis in hepatocyte-like VL-17A cells. J. Biol. Chem. 2007, 282:31900-31908.
46. Wang N.S., Unkila M.T., Reineks E.Z., Distelhorst C.W. Transient expression of wildtype or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death. J. Biol. Chem. 2001, 276:44117-44128.
47. Webb B., Walker D.W., Heaton M.B. Nerve growth factor and chronic ethanol treatment alter calcium homeostasis in developing rat septal neurons. Brain Res. Dev. Brain Res. 2003, 143:57-71.
48. Wolf B.B., Green D.R. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999, 274:20049-20052.
49. Wu D., Cederbaum A.I. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcohol. Clin. Exp. Res. 1999, 23:67-76.
50. Young C., Klocke B.J., Tenkova T., Choi J., Labruyere J., Qin Y.-Q., et al. Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ. 2003, 10:1148-1155.
51. Zhou Z., Sun X., Kang Y.J. Ethanol-induced apoptosis in mouse liver: fas- and cytochrome c-mediated caspase-3 activation pathway. Am. J. Pathol. 2001, 159:329-338.
52. Zou H., Li Y., Liu X., Wang X. An apaf-1 cytochrome c multimeric complex is a functional apotosome that activates procaspase-9. J. Biol. Chem. 1999, 274:11549-11556.