Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats

World Journal of Gastroenterology

Volumn 11, Issue 24, 2005, Pages 3746-3750

  Chen, Sheng Hsuan ^a   Liang, Yu Chih ^a   Chao, Jane C J ^a   Tsai, Li Hsueh ^a   Chang, Chun Chao ^a   Wang, Chia Chi ^b   Pan, Shiann ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b MIN SHENG GENERAL HOSPITAL   (Taiwan)

Author keywords

c Jun kinase; Ethanol; Gastric ulcer; Ginkgo biloba extract

Indexed keywords

ALCOHOL; CERENIN; GINKGO BILOBA EXTRACT; MALONALDEHYDE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; LIPID PEROXIDATION; NONHUMAN; PRIMARY PREVENTION; PYLORUS LIGATION; RANDOMIZATION; RAT; RAT STRAIN; STOMACH JUICE; STOMACH MUCOSA; STOMACH MUCUS; STOMACH PH; STOMACH PROTECTION; STOMACH SECRETION; STOMACH ULCER;

EID: 23844551235     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i24.3746     Document Type: Article

References (32)

1. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992; 340: 1136-1139
2. Pincemail J, Dupuis M, Nasr C, Hans P, Haag-Berrurier M, Anton R, Deby C. Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo Biloba extract. Experientia 1989; 45: 708-712
3. Gardès-Albert M, Ferradini C, Sekaki A, Droy-Lefaix MT. Oxygen-centered free radicals and their interactions with EGb 761 or CP 202. In: Ferradini C, Droy-Lefaix MT, Christen Y, eds. Advances in Ginkgo biloba extract research: Ginkgo biloba extract (EGb 761) as a free-radical scavenger. New York Elsevier Science 1993: 1-11
4. Akiba S, Kawauchi T, Oka T, Hashizume T, Sato T. Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation. Biochem Mol Biol Int 1998; 46: 1243-1248
5. Akisu M, Kultursay N, Coler I, Huseyinov A. Platelet-activating factor is an important mediator in hypoxic ischemia brain injury in the newborn rat. Flunarizine and Ginkgo biloba extract reduce PAF concentration in the brain. Biol Neonate 1998; 74: 439-444
6. Kleijnen J, Knipschild P. Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmac 1992; 34: 352-358
7. Oates PJ, Hakkinen JP. Studies on the mechanism of ethanol-induced gastric damage in rat. Gastroenterology 1988; 94: 10-21
8. Szabo S, Goldberg I. Experimental pathogenesis: drugs and chemical lesions in the gastric mucosa. Scand J Gastroenterol Suppl 1990; 174: 1-8
9. Pihan G, Regillo C, Szabo S. Free radicals and lipid peroxidation in ethanol- and aspirin-induced gastric mucosal injury. Dig Dis Sci 1987; 32: 1395-1401
10. Szelenyi I, Brune K. Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 1988; 33: 865-871
11. Wang Q, Zhao WZ, Ma CG. Protective effects of Gingko biloba extract on gastric mucosa. Acta Pharmacol Sin 2000; 21: 1153-1156
12. Liang YC, Huang YT, Tsai SH, Lin-Shiau SY, Chen CF, Lin JK. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 1999; 20: 1945-1952
13. Boyd SC, Sasame HA, Boyd MR. High concentrations of glutathione in glandular stomach: possible implications for carcinogenesis. Science 1979; 205: 1010-1012
14. Videla LA, Valenzuela A. Alcohol injection, liver glutathione and lipid peroxidation: metabolic interaction and pathological implication. Life Sci 1982; 31: 2395-2407
15. Li T, Zhang XJ. Involvement of sulfhydryls in the protective mechanism of gastric mucosa. Acta Physiol Sinica 1990; 42: 571-577
16. Allen A, Cunliffe WJ, Pearson JP, Sellers LA, Ward R. Studies on gastrointestinal mucus. Scand J Gastroenterol Suppl 1984; 93: 101-113
17. Salim AS. Sulfhydryl-containing agents: new approach to the problem of refractory peptic ulceration. Pharmacology 1993; 46: 281-288
18. Garner A, Flemstrom G, Allen A, Heylings JR, McQueen S. Gastric mucosal protective mechanisms: role of epithelial bicarbonate and mucus secretions. Scand J Gastroenterol Suppl 1984; 101: 79-86
19. Farre AJ, Colombo M, Alvarez I, Glavin GB. Some novel 5-hydroxytryptamine 1A (5-HT1A) receptor agonists reduce gastric acid and pepsin secretion, reduce experimental gastric mucosal injury and enhance gastric mucin in rats. J Pharmacol Exp Ther 1995; 272: 832-837
20. Grisham MB, Von Ritter C, Smith BF, Lamont JT, Granger DN. Interaction between oxygen radicals and gastric mucin. Am J Physiol 1987; 253(1 Pt 1): G93-96
21. Cross CE, Halliwell B, Allen A. Antioxidant protection: a function of tracheobronchial and gastrointestinal mucus. Lancet 1984; 1: 328-330
22. Gong DH, Turner B, Bhaskar KR, Lamont JT. Lipid binding to gastric mucin: protective effect against oxygen radicals. Am J Physiol 1990; 259(4 Pt 1): G681-686
23. Hiraishi H, Terano A, Ota S, Mutoh S, Sugimoto T, Hirada T, Razandi M, Ivey KJ. Role for mucus glycoprotein in protecting cultured gastric mucosal cells against toxic oxygen metabolites. J Lab Clin Med 1993; 121: 570-578
24. Terano A, Hiraishi H, Ota S, Shiga J, Sugimoto T. Role of superoxide and hydroxyradicals in rat gastric mucosal injury induced by ethanol. Gastroenterol Jpn 1989; 24: 488-493
25. Mutoh H, Hiraishi H, Ota S, Ivey KJ, Terano A, Sugimoto T. Role of oxygen radicals in ethanol-induced damage to cultured gastric mucosal cells. Am J Physiol 1990; 258(4 Pt 1): G603-609
26. Slomiany A, Morita M, Sano S, Piotrowski J, Skrodzka D, Slomiany BL. Effect of ethanol on gastric mucus glycoprotein synthesis, translocation, transport, glycosylation and secretion. Alcohol Clin Exp Res 1997; 21: 417-423
27. Piotrowaki J, Piotrowaki E, Strodzka D, Slomiany A, Slomiany BL. Gastric mucosal apoptosis induced by ethanol: effect of antiulcer agents. Biochem Mol Biol Int 1997; 42: 247-254
28. Mizushima T, Tsutsumi S, Rokutan K, Tsuchiya T. Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells. Dig Dis Sci 1999; 44: 510-514
29. Hoshino T, Takano T, Tsutsumi S, Tomisato W, Tsuchiya T, Mizushima T. Effects of prostaglandin E2 on gastric irritant-induced apoptosis. Dig Dis Sci 2002; 47: 2370-2379
30. Marcocci L, Maguire JJ, Dory-Lefaix L. The nitric oxide-scavenging properties of Gingo biloba extract Egb761. Biochem Biophys Res Commun 1994; 201: 748-755
31. Kim HK, Son KH, Chang HW, Kang SS, Kim HP. Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves. Planta Med 1999; 65: 465-467
32. Yoshikawa T, Naito Y, Kondo M. Ginkgo biloba leaf extract: review of biological actions and clinical applications. Antioxid Redox Signal 1999; 1: 469-480