Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction

American Journal of Physiology - Renal Physiology

Volumn 279, Issue 1 48-1, 2000, Pages

  Hruska, Keith A ^a,b   Guo, Guangjie ^a,b   Wozniak, Magdalena ^a   Martin, Daniel ^a   Miller, Steven ^a   Liapis, Helen ^b   Loveday, Kenneth ^c   Klahr, Saulo ^a   Sampath, T Kuber ^c   Morrissey, Jeremiah ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BARNES JEWISH HOSPITAL   (United States)

^c CURIS INC   (United States)

Author keywords

Kidney morphogens; Renal failure; Tubular atrophy; Tubulointerstitial fibrosis

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; ENALAPRIL; OSTEOGENIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATROPHY; CONTROLLED STUDY; ENZYME INHIBITION; FIBROGENESIS; KIDNEY BLOOD FLOW; KIDNEY DEVELOPMENT; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY TUBULE EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; RAT; URETER OBSTRUCTION;

EID: 17544379605     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2000.279.1.f130     Document Type: Article

References (54)

1. Almanzar MM, Frazier KS, Dube PH, Piqueras AN, Jones WK, Charette MF, and Paredes AL. Osteogenic protein-1 mRNA expression is selectively modulated after acute ischemic renal injury. J Am Soc Nephrol 9: 1456-1463, 1998.
2. Alvarez RJ, Sun MJ, Haverty TP, Iozzo RV, Myers JC, and Neilson EG. Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. Kidney Int 41: 14-23, 1992.
3. Anderson S, Meyer TW, Rennke HG, and Brenner BM. Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest 76: 612-619, 1986.
4. Bidani AK and Griffin KA. Experimental models of renal mass reduction and their relevance to clinical medicine. Kidney Curr Surv World Lit 4: 4-9, 1995.
5. Border WA and Noble NA. Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis. Hypertension 31: 181-188, 1998.
6. Bruzzi I, Benigni A, and Ramuzzi G. Role of increased glomerular protein traffic in the progression of renal failure. Kidney Int 62: S29-S31, 1997.
7. Chevalier RL, Goyal S, Wolstenholme JT, and Thornhill BA. Obstructive nephropathy in the neonatal rat is attenuated by epidermal growth factor. Kidney Int 54: 38-47, 1998.
8. Chevalier RL, Kim A, Thornhill BA, and Wolstenholme JT. Recovery following relief of unilateral ureteral obstruction in the neonatal rat. Kidney Int 55: 793-807, 1999.
9. Chevalier RL, Thornhill BA, and Wolstenholme JTKA. Unilateral ureteral obstruction in early development alters renal growth: dependence on the duration of obstruction. J Urol 161: 309-313, 1999.
10. 1 receptors during neonatal ureteral obstruction. Am J Physiol Renal Fluid Electrolyte Physiol 268: F1117-F1123, 1995.
11. Couser WG. Mediators of immune glomerular injury. Clin Invest 71: 8-11, 1993.
12. Couser WG. Pathogenesis of glomerulonephritis. Kidney Int 44: S519-S526, 1993.
13. Diamond JR, Kees-Folts D, Ding G, Frye JE, and Restrepo NC. Macrophages, monocyte peptide-1, and TGF-β1 in experimental hydronephrosis. Am J Physiol Renal Fluid Electrolyte Physiol 266: F926-F933, 1994.
14. Douglas JG, Romero M, and Hopper U. Signaling mechanisms coupled to the angiotensin receptor of proximal tubule epithelium. Kidney Int 38: S43-S47, 1990.
15. Dudley AT, Lyons KM, and Robertson EJ. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9: 2795-2807, 1995.
16. Eddy AA. Interstitial inflammation and fibrosis in rats with diet-induced hypercholesterolemia. Kidney Int 50: 1139-1149, 1996.
17. El-Dahr SS, Gee J, Dipp S, Hanss BG, Vari RC, and Chao J. Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy. Am J Physiol Renal Fluid Electrolyte Physiol 264: F874-F881, 1993.
18. Fern RJ, Yesko CM, Thornhill BA, Kim H-Y, Smithies O, and Chevalier RL. Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice. J Clin Invest 103: 39-46, 1999.
19. Floege J, Hudkins KL, Eitner F, Cui Y, Morrison RS, Schelling MA, and Alpers CE. Localization of fibroblast growth factor-2 (basic FGF) and FGF receptor-1 in adult human kidney. Kidney Int 56: 883-897, 1999.
20. Gröne EF, Walli AK, Gröne HJ, Miller B, and Seidel D. The role of lipids in nephrosclerosis and glomerulosclerosis. Atherosclerosis 107: 1-13, 1994.
21. Helder MN, Ozkaynak E, Sampath KT, Lluyten FP, Latin V, Oppermann H, and Vukicevic S. Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development. J Histochem Cytochem 43: 1035-1044, 1995.
22. Ibrahim HN, Rosenberg ME, and Hostetter TH. Role of the renin-angiotensin-aldosterone system in the progression of renal disease: a critical review. Semin Nephrol 17: 431-440, 1997.
23. Ishidoya S, Morrissey J, McCracken R, and Mahr S. Delayed treatment with enalapril halts tuhulointerstitial fibrosis in rats. Kidney Int 49: 1110-1119, 1996.
24. Ishidoya S, Morrissey J, McCracken R, Reyes A, and Klahr S. Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral ligation. Kidney Int 47: 1285-1294, 1995.
25. Johnson RJ, Alpers CE, Yoshimura A, Lombardi D, Pritzl P, Floege J, and Schwartz SM. Renal injury from angiotensin II-mediated hypertension. Hypertension 19: 464-467, 1992.
26. Johnson RJ, Hugo C, Haseley C, Pichler RH, Bassuk J, Thomas S, Suga S, Couser WG, and Shankland SJ. Mechanisms of progressive glomerulosclerosis and tubulointerstitial fibrosis. Clin Exp Nephrol 2: 307-312, 1998.
27. Jones WK, Richmond EA, White K, Sasak HKW, Smart J, Oppermann H, Rueger IJC, and Tucker RF. Osteogenic protein-1 (OP-1) expression and processing in Chinese hamster ovary cells: isolation of a soluble complex containing the mature and pro-domains of OP-1. Growth Factors 11: 215-225, 1994.
28. Kagami S, Border WA, Miller DE, and Noble NA. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest 93: 2431-2437, 1994.
29. Kaneto H, Morrissey J, and Klahr S. Increased expression of TGF-β1 mRNA in the obstructed kidney of rats with unilateral ligation. Kidney Int 44: 313-321, 1993.
30. Kaneto H, Morrissey J, McCracken R, Ishidoya S, Reyes A, and Klahr S. The expression of mRNA for tumor necrosis factor increases in the obstructed kidney of rats soon after unilateral ureteral ligation. Nephrology 2: 161-166, 1996.
31. Kaneto H, Morrissey J, McCracken R, Reyes A, and Klahr S. Enalapril reduces collagen type IV synthesis and expansion on the interstitium in the obstructed kidney. Kidney Int 45: 1637-1647, 1994.
32. Klahr S. S. Nephrology forum: obstructive nephropathy. Kidney Int. 54: 286-300, 1998.
33. Klahr S, Ishidoya S, and Morrissey J. Role of angiotensin II in the tubulointerstitial fibrosis of obstructive nephropathy. Am J Kidney Dis 26: 141-146, 1995.
34. Klahr S and Morrissey J. Angiotensin II and gene expression in the kidney. Am J Kidney Dis 31: 171-176, 1998.
35. Lewis E J, Hunsicker LG, Bain RP, and Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med 329: 1456-1462, 1993.
36. Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, and Karsenty G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9: 2808-2820, 1995.
37. Massaque J. The transforming growth factor-β family. Annu Rev Cell Biol 6: 597-641, 1990.
38. Miller SB, Martin DR, Kissane J, and Hammerman MR. Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats. Am J Physiol Renal Fluid Electrolyte Physiol 266: F129-F134, 1994.
39. Miller SB, Moulton M, O'Shea M, and Hammerman MR. Effects of IGF-I on renal function in end-stage renal failure. Kidney Int 46: 201-207, 1994.
40. Modi KS, Morrissey J, Shah SV, Schreiner GF, and Klahr S. Effects of probucol on renal function in rats with bilateral ureteral obstruction. Kidney Int 38: 843-850, 1990.
41. Moller JC, Skriver E, Olsen S, and Maunsbach AB. Ultrastructural analysis of human proximal tubules and cortical interstitium in chronic renal disease (hydronephrosis). Virchows Arch 402: 209-237, 1984.
42. Nagle RB, Johnson ME, and Jervis HR. Proliferation of renal interstitial cells following injury induced by ureteral obstruction (Abstract). Lab Invest 35: 18, 1976.
43. Ng YY, Huang TP, Yang WC, Chen ZP, Yang AH, Mu W, Nikolic-Paterson DJ, and Atkins RCLHY. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 54: 864-876, 1998.
44. Oikawa T, Freeman M, Lo W, Vaughan DE, and Fogo A. Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition. Kidney Int 51: 164-172, 1997.
45. Ozkaynak E, Schnegelsberg PN, and Oppermann H. Murine osteogenic protein 1 (OP-1): high levels of mRNA in kidney. Biochem Biophys Res Commun 179: 116-123, 1991.
46. Sampath TK, Maliakal JC, Hauschka PV, Jones WK, Sasak H, Tucker RF, White KH, Coughlin JE, Tucker MM, Pang RHL, Corbett C, Ozkaynak E, Oppermann H, and Rueger DC. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 267: 20352-20362, 1992.
47. Simon M, Maresh JG, Harris SE, Hernandez JD, Arar M, Olson MS, and Abboud HE. Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney. Am J Physiol Renal Physiol 276: F382-F389, 1999.
48. Solursh M, Langille RM, Wood J, and Sampath TK. Osteogenic protein-1 is required for mammalian eye development. Biochem Biophys Res Commun 218: 438-443, 1996.
49. Truong LD, Sheikh-Hamad D, Chakraborty S, and Suki WN. Cell apoptosis and proliferation in obstructive uropathy. Semin Nephrol 18: 641-651, 1998.
50. Vukicevic S, Basic V, Rogic D, Basic N, Shih M-S, Shepard A, Jin D, Dattatrenamurty B, Jones W, Dorai H, Ryan S, Griffiths D, Maliakal J, Jelic M, Pastorcic M, Stavlijenic A, and Sampath TK. Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. J Clin Invest 102: 202-214, 1998.
51. Vukicevic S, Kopp JB, Luyten FP, and Sampath TK. Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). PNAS 93: 9021-9026, 1996.
52. 2 receptors in neonatal ureteral obstruction. Am J Physiol Regulatory Integrative Comp Physiol 273: R503-R509, 1997.
53. Yoo KH, Thornhill BA, Wolstenholme JT, and Chevalier RL. Tissue-specific regulation of growth factors and clusterin by angiotensin II. Am J Hypertens 11: 715-722, 1998.
54. Zatz R, Dunn BR, Meyer TW, Anderson S, Rennke HG, and Brenner BM. Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension J Clin Invest 77: 1925-1930, 1986.