The tumor microenvironment and DNA repair

Seminars in Radiation Oncology

Volumn 20, Issue 4, 2010, Pages 282-287

  Klein, Thomas J ^a   Glazer, Peter M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; RAD51 PROTEIN; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F4;

BASE MISPAIRING; CELL CYCLE; CELL HYPOXIA; CLINICAL PRACTICE; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; EXCISION REPAIR; GENETIC STABILITY; HUMAN; MISMATCH REPAIR; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REOXYGENATION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR MICROENVIRONMENT;

ANIMALS; ANOXIA; DNA REPAIR; DNA, NEOPLASM; HUMANS; MUTATION; TUMOR MICROENVIRONMENT;

EID: 77956457530     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semradonc.2010.05.006     Document Type: Review

References (36)

1. Lobo N.A., Shimono Y., Qian D., et al. The biology of cancer stem cells. Annu Rev Cell Dev Biol 2007, 23:675-699.
2. Tlsty T.D., Coussens L.M. Tumor stroma and regulation of cancer development. Annu Rev Pathol 2006, 1:119-150.
3. Keith B., Simon M.C. Hypoxia-inducible factors, stem cells, and cancer. Cell 2007, 129:465-472.
4. Folkman J. Angiogenesis. Annu Rev Med 2006, 57:1-18.
5. Nowell P.C. The clonal evolution of tumor cell populations. Science 1976, 194:23-28.
6. Sidransky D., Hollstein M. Clinical implications of the p53 gene. Annu Rev Med 1996, 47:285-301.
7. Bartek J., Bartkova J., Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007, 26:7773-7779.
8. Rice G.C., Hoy C., Schimke R.T. Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci U S A 1986, 83:5978-5982.
9. Young S.D., Marshall R.S., Hill R.P. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A 1988, 85:9533-9537.
10. Reynolds T.Y., Rockwell S., Glazer P.M. Genetic instability induced by the tumor microenvironment. Cancer Res 1996, 56:5754-5757.
11. Yuan J., Narayanan L., Rockwell S., et al. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 2000, 60:4372-4376.
12. Hammond E.M., Dorie M.J., Giaccia A.J. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003, 278:12207-12213.
13. Wood R.D. DNA repair in eukaryotes. Annu Rev Biochem 1996, 65:135-167.
14. Norbury C.J., Hickson I.D. Cellular responses to DNA damage. Annu Rev Pharmacol Toxicol 2001, 41:367-401.
15. Mihaylova V.T., Bindra R.S., Yuan J., et al. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol 2003, 23:3265-3273.
16. Koshiji M., To K.K., Hammer S., et al. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell 2005, 17:793-803.
17. Bindra R.S., Glazer P.M. Co-repression of mismatch repair gene expression by hypoxia in cancer cells: Role of the Myc/max network. Cancer Lett 2007, 252:93-103.
18. Bindra R.S., Schaffer P.J., Meng A., et al. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol 2004, 24:8504-8518.
19. Bindra R.S., Gibson S.L., Meng A., et al. Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res 2005, 65:11597-11604.
20. Corn P.G., Ricci M.S., Scata K.A., et al. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol Ther 2005, 4:1285-1294.
21. Nakamura H., Tanimoto K., Hiyama K., et al. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. Oncogene 2008, 27:4200-4209.
22. Ren B., Cam H., Takahashi Y., et al. E2F integrates cell cycle progression with DNA repair, replication, and G 2/M checkpoints. Genes Dev 2002, 16:245-256.
23. Oberley M.J., Inman D.R., Farnham P.J. E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine. 9. J Biol Chem 2003, 278:42466-42476.
24. Wang A., Schneider-Broussard R., Kumar A.P., et al. Regulation of BRCA1 expression by the Rb-E2F pathway. J Biol Chem 2000, 275:4532-4536.
25. Bindra R.S., Glazer P.M. Repression of Rad51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene 2007, 26:2048-2057.
26. Crosby M.E., Kulshreshtha R., Ivan M., et al. Regulation of DNA repair gene expression in hypoxic stress. Cancer Res 2009, 69:1221-1229.
27. Lee Y.S., Dutta A. microRNAs in cancer. Annu Rev Pathol 2009, 4:199-227.
28. Chan N., Koritzinsky M., Zhao H., et al. Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res 2008, 68:605-614.
29. Fong P.C., Boss D.S., Yap T.A., et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009, 361:123-134.
30. Hegan D.C., Lu Y., Stachelek G.C., et al. Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. Proc Natl Acad Sci U S A 2010, 107:2201-2206.
31. Helleday T., Bryant H.E., Schultz N. Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle 2005, 4:1176-1178.
32. Fink D., Nebel S., Aebi S., et al. The role of DNA mismatch repair in platinum drug resistance. Cancer Res 1996, 56:4881-4886.
33. Haffty B.G., Son Y.H., Papac R., et al. Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: Results of the Yale mitomycin randomized trials. J Clin Oncol 1997, 15:268-276.
34. Sartorelli A.C., Hodnick W.F., Belcourt M.F., et al. Mitomycin C: A prototype bioreductive agent. Oncol Res 1994, 6:501-508.
35. He C., Klionsky D.J. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009, 43:67-93.
36. Rosenberg S.M. Evolving responsively: Adaptive mutation. Nat Rev Genet 2001, 2:504-515.