Proteomic and phototoxic characterization of melanolipofuscin: Correlation to disease and model for its origin

Molecular Vision

Volumn 13, Issue , 2007, Pages 318-329

  Warburton, Sarah ^a   Davis, Wayne E ^a   Southwick, Katie ^a   Xin, Huijun ^a   Woolley, Adam T ^a   Burton, Gregory F ^a   Thulin, Craig D ^a  

^a Brigham Young University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOFUSCIN; MELANOLIPOFUSCIN; PIGMENT; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; ATOMIC FORCE MICROSCOPY; AUTOPHAGY; CELL SPECIFICITY; CONTROLLED STUDY; CORRELATION ANALYSIS; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOSOME; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHAGOCYTOSIS; PHOTORECEPTOR; PHOTOTOXICITY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; RETINA MACULA AGE RELATED DEGENERATION; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; UNINDEXED SEQUENCE;

ADULT; AGED; CYTOPLASMIC GRANULES; HUMANS; IMMUNOBLOTTING; LIPOFUSCIN; MACULAR DEGENERATION; MELANOSOMES; MODELS, BIOLOGICAL; PHOTORECEPTORS; PIGMENT EPITHELIUM OF EYE; PROTEOME; PROTEOMICS; RHODOPSIN; SPECTROMETRY, FLUORESCENCE;

EID: 33847355664     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000; 45:115-34.
2. Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxidative damage and age-related macular degeneration. Mol Vis 1999; 5:32.
3. Wassell J, Davies S, Bardsley W, Boulton M. The photoreactivity of the retinal age pigment lipofuscin. J Biol Chem 1999; 274:23828-32.
4. Rozanowska M, Jarvis-Evans J, Korytowski W, Boulton ME, Burke JM, Sarna T. Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species. J Biol Chem 1995; 270:18825-30.
5. Feeney-Burns L, Hilderbrand ES, Eldridge S. Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci 1984; 25:195-200.
6. Sarna T. Properties and function of the ocular melanin - a photobiophysical view. J Photochem Photobiol B 1992; 12:215-58.
7. Schraermeyer U, Peters S, Thumann G, Kociok N, Heimann K. Melanin granules of retinal pigment epithelium are connected with the lysosomal degradation pathway. Exp Eye Res 1999; 68:237-45.
8. Dunford R, Land EJ, Rozanowska M, Sarna T, Truscott TG. Interaction of melanin with carbon- and oxygen-centered radicals from methanol and ethanol. Free Radic Biol Med 1995; 19:735-40.
9. Rozanowska M, Sarna T, Land EJ, Truscott TG. Free radical scavenging properties of melanin interaction of eu- and pheo-melanin models with reducing and oxidising radicals. Free Radic Biol Med 1999; 26:518-25.
10. Sarna T, Menon IA, Sealy RC. Photosensitization of melanins: a comparative study. Photochem Photobiol 1985; 42:529-32.
11. Boulton M, Rozanowska M, Rozanowski B. Retinal photodamage. J Photochem Photobiol B 2001; 64:144-61.
12. Korytowski W, Kalyanaraman B, Menon IA, Sarna T, Sealy RC. Reaction of superoxide anions with melanins: electron spin resonance and spin trapping studies. Biochim Biophys Acta 1986; 882:145-53.
13. Sarna T, Burke JM, Korytowski W, Rozanowska M, Skumatz CM, Zareba A, Zareba M. Loss of melanin from human RPE with aging: possible role of melanin photooxidation. Exp Eye Res 2003; 76:89-98.
14. Dayhaw-Barker P, Davies S, Shamsi FA, Rozanowska M, Rozanowska B, Boulton M. The phototoxicity of aged RPE melanosomes. Invest Ophthalmol Vis Sci 2001; 42: S755
15. Gaillard E, Hill C, Griffiths D. UVC and visible light damage to re-pigmented RPE cells. ARVO Annual Meeting; 2003 May 4-9; Fort Lauderdale (FL).
16. Rozanowska M, Korytowski W, Rozanowski B, Skumatz C, Boulton ME, Burke JM, Sarna T. Photoreactivity of aged human RPE melanosomes: a comparison with lipofuscin. Invest Ophthalmol Vis Sci 2002; 43:2088-96.
17. Boulton M. Ageing of the retinal pigment epithelium. In: Osborne NN, Chader G, editors. Progress in retinal research. Vol 11. Oxford: Pergamon; 1991. p. 125-51.
18. Feeney L. Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies. Invest Ophthalmol Vis Sci 1978; 17:583-600.
19. Schraermeyer U, Stieve H. A newly discovered pathway of melanin formation in cultured retinal pigment epithelium of cattle. Cell Tissue Res 1994; 276:273-9.
20. Warburton S, Southwick K, Hardman RM, Secrest AM, Grow RK, Xin H, Woolley AT, Burton GF, Thulin CD. Examining the proteins of functional retinal lipofuscin using proteomic analysis as a guide for understanding its origin. Mol Vis 2005; 11:1122-34.
21. Dorey CK, Torres X, Swart T. Evidence of melanogenesis in porcine retinal pigment epithelial cells in vitro. Exp Eye Res 1990; 50:1-10.
22. Boulton M, Docchio F, Dayhaw-Barker P, Ramponi R, Cubeddu R. Age-related changes in the morphology, absorption and fluorescence of melanosomes and lipofuscin granules of the retinal pigment epithelium. Vision Res 1990; 30:1291-303.
23. Sparrow JR, Nakanishi K, Parish CA. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 2000; 41:1981-9.
24. Shevchenko A, Wilm M, Vorm O, Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 1996; 68:850-8.
25. Old WM, Meyer-Arendt K, Aveline-Wolf L, Pierce KG, Mendoza A, Sevinsky JR, Resing KA, Ahn NG. Comparison of label-free methods for quantifying human proteins by shotgun proteomics. Mol Cell Proteomics 2005; 4:1487-502.
26. Takemoto DJ, Spooner B, Takemoto LJ. Antisera to synthetic peptides of bovine rhodopsin: use as site-specific probes of disc membrane changes in retinal dystrophic dogs. Biochem Biophys Res Commun 1985; 132:438-44.
27. Vollmer-Snarr HR, Pew MR, Alvarez ML, Cameron DJ, Chen Z, Walker GL, Price JL, Swallow JL. Amino-retinoid compounds in the human retinal pigment epithelium. In: Retinal Degenerative Diseases. Hollyfield JG, Anderson RE, LaVail MM, eds. New York, Springer; 2006. p. 69-74.
28. Azarian SM, McLeod I, Lillo C, Gibbs D, Yates JR, Williams DS. Proteomic analysis of mature melanosomes from the retinal pigmented epithelium. J Proteome Res 2006; 5:521-9.
29. Garin J, Diez R, Kieffer S, Dermine JF, Duclos S, Gagnon E, Sadoul R, Rondeau C, Desjardins M. The phagosome proteome: insight into phagosome functions. J Cell Biol 2001; 152:165-80.
30. Basrur V, Yang F, Kushimoto T, Higashimoto Y, Yasumoto K, Valencia J, Muller J, Vieira WD, Watabe H, Shabanowitz J, Hearing VJ, Hunt DF, Appella E. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J Proteome Res 2003; 2:69-79.
31. Antioxidant status and neovascular age-related macular degeneration. Eye Disease Case-Control Study Group. Arch Ophthalmol 1993; 111:104-9. Errata in: Arch Ophthalmol 1993; 111:1228. Arch Ophthalmol 1993; 111:1366. Arch Ophthalmol 1993; 111:1499.
32. Orlow SJ. Melanosomes are specialized members of the lysosomal lineage of organelles. J Invest Dermatol 1995; 105:3-7.
33. Raposo G, Marks MS. The dark side of lysosome-related organelles: specialization of the endocytic pathway for melanosome biogenesis. Traffic 2002; 3:237-48.