메뉴 건너뛰기




Volumn 9, Issue 9, 2010, Pages 4501-4512

Liquid chromatography - Mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease

(20)  Barr, Jonathan a,e,k   Vázquez Chantada, Mercedes b   Alonso, Cristina a   Pérez Cormenzana, Miriam b   Mayo, Rebeca a   Galán, Asier c   Caballería, Juan d   Martín Duce, Antonio d   Tran, Albert e,f,g   Wagner, Conrad h,i   Luka, Zigmund h   Lu, Shelly C j   Castro, Azucena a   Le Marchand Brustel, Yannick e,f,g   Martínez Chantar, M Luz a   Veyrie, Nicolas a   Clément, Karine a   Tordjman, Joan a   Gual, Philippe e,f,g   Mato, José M b  

e INSERM   (France)

Author keywords

biomarkers; metabolomics; NAFLD; NASH; steatosis

Indexed keywords

ARACHIDONIC ACID; BIOLOGICAL MARKER; GLUTAMIC ACID;

EID: 77956326416     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr1002593     Document Type: Article
Times cited : (136)

References (95)
  • 1
    • 4444228888 scopus 로고    scopus 로고
    • World Health Organization. In Geneva,; Factsheet No. 3011.
    • World Health Organization. Obesity and Overweight; In Geneva, 2006; Factsheet No. 3011.
    • (2006) Obesity and Overweight
  • 2
    • 0034831067 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis
    • Reid, A. E. Nonalcoholic steatohepatitis Gastroenterology 2001, 121 (3) 710-23
    • (2001) Gastroenterology , vol.121 , Issue.3 , pp. 710-23
    • Reid, A.E.1
  • 3
    • 0037223610 scopus 로고    scopus 로고
    • Defining nonalcoholic fatty liver disease: Implications for epidemiologic studies
    • Clark, J. M.; Diehl, A. M. Defining nonalcoholic fatty liver disease: implications for epidemiologic studies Gastroenterology 2003, 124 (1) 248-50
    • (2003) Gastroenterology , vol.124 , Issue.1 , pp. 248-50
    • Clark, J.M.1    Diehl, A.M.2
  • 5
    • 35348900749 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Adams, L. A.; Lindor, K. D. Nonalcoholic fatty liver disease Ann. Epidemiol. 2007, 17 (11) 863-9
    • (2007) Ann. Epidemiol. , vol.17 , Issue.11 , pp. 863-9
    • Adams, L.A.1    Lindor, K.D.2
  • 6
    • 34547491854 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease
    • Angulo, P. Obesity and nonalcoholic fatty liver disease Nutr. Rev. 2007, 65 (6 Pt 2) S57-63
    • (2007) Nutr. Rev. , vol.65 , Issue.6 PART 2 , pp. 57-63
    • Angulo, P.1
  • 7
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal lipid and glucose metabolism in obesity: Implications for nonalcoholic fatty liver disease
    • Parekh, S.; Anania, F. A. Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease Gastroenterology 2007, 132 (6) 2191-207
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2191-207
    • Parekh, S.1    Anania, F.A.2
  • 10
    • 7044231396 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Recent trends in the United States
    • El-Serag, H. B. Hepatocellular carcinoma: recent trends in the United States Gastroenterology 2004, 127 (5) S27-34
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. 27-34
    • El-Serag, H.B.1
  • 11
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • Malhi, H.; Gores, G. J. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease Semin. Liver Dis. 2008, 28 (4) 360-9
    • (2008) Semin. Liver Dis. , vol.28 , Issue.4 , pp. 360-9
    • Malhi, H.1    Gores, G.J.2
  • 12
    • 34248653254 scopus 로고    scopus 로고
    • Role of S-adenosyl-L-methionine in liver health and injury
    • Mato, J. M.; Lu, S. C. Role of S-adenosyl-L-methionine in liver health and injury Hepatology 2007, 45 (5) 1306-12
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1306-12
    • Mato, J.M.1    Lu, S.C.2
  • 14
    • 67649380355 scopus 로고    scopus 로고
    • Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: Influence of glycemic status
    • Tordjman, J.; Poitou, C.; Hugol, D.; Bouillot, J. L.; Basdevant, A.; Bedossa, P.; Guerre-Millo, M.; Clement, K. Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status J. Hepatol. 2009, 51 (2) 354-62
    • (2009) J. Hepatol. , vol.51 , Issue.2 , pp. 354-62
    • Tordjman, J.1    Poitou, C.2    Hugol, D.3    Bouillot, J.L.4    Basdevant, A.5    Bedossa, P.6    Guerre-Millo, M.7    Clement, K.8
  • 15
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell, G. C.; Larter, C. Z. Nonalcoholic fatty liver disease: from steatosis to cirrhosis Hepatology 2006, 43 (2) S99-S112
    • (2006) Hepatology , vol.43 , Issue.2
    • Farrell, G.C.1    Larter, C.Z.2
  • 16
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
    • Dixon, J. B.; Bhathal, P. S.; Hughes, N. R.; O'Brien, P. E. Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss Hepatology 2004, 39 (6) 1647-54
    • (2004) Hepatology , vol.39 , Issue.6 , pp. 1647-54
    • Dixon, J.B.1    Bhathal, P.S.2    Hughes, N.R.3    O'brien, P.E.4
  • 18
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless, I. R.; Lentz, J. S. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors Hepatology 1990, 12 (5) 1106-10
    • (1990) Hepatology , vol.12 , Issue.5 , pp. 1106-10
    • Wanless, I.R.1    Lentz, J.S.2
  • 20
  • 21
    • 48449103834 scopus 로고    scopus 로고
    • Review article: Diagnosis and treatment of non-alcoholic fatty liver disease
    • Oh, M. K.; Winn, J.; Poordad, F. Review article: diagnosis and treatment of non-alcoholic fatty liver disease Aliment Pharmacol. Ther. 2008, 28 (5) 503-22
    • (2008) Aliment Pharmacol. Ther. , vol.28 , Issue.5 , pp. 503-22
    • Oh, M.K.1    Winn, J.2    Poordad, F.3
  • 24
    • 33644525960 scopus 로고    scopus 로고
    • FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases
    • author reply 375-6
    • Castera, L.; Foucher, J.; Bertet, J.; Couzigou, P.; de Ledinghen, V. FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases Hepatology 2006, 43 (2) 373-4; author reply 375-6
    • (2006) Hepatology , vol.43 , Issue.2 , pp. 373-4
    • Castera, L.1    Foucher, J.2    Bertet, J.3    Couzigou, P.4    De Ledinghen, V.5
  • 26
    • 12344267742 scopus 로고    scopus 로고
    • Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C
    • Poynard, T, I.-B. F.; Munteanu, M.; Messous, D.; Myers, R. P.; Thabut, D.; Ratziu, V.; Mercadier, A.; Benhamou, Y; Hainque, B. Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C Comp. Hepatol. 2004, 4, 10-23
    • (2004) Comp. Hepatol. , vol.4 , pp. 10-23
    • Poynard, T.I.-B.F.1    Munteanu, M.2    Messous, D.3    Myers, R.P.4    Thabut, D.5    Ratziu, V.6    Mercadier, A.7    Benhamou, Y.8    Hainque, B.9
  • 27
    • 11144355931 scopus 로고    scopus 로고
    • Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors
    • Imbert-Bismut, F.; Messous, D.; Thibault, V.; Myers, R. B.; Piton, A.; Thabut, D.; Devers, L.; Hainque, B.; Mercadier, A.; Poynard, T. Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors Clin. Chem. Lab. Med. 2004, 42 (3) 323-33
    • (2004) Clin. Chem. Lab. Med. , vol.42 , Issue.3 , pp. 323-33
    • Imbert-Bismut, F.1    Messous, D.2    Thibault, V.3    Myers, R.B.4    Piton, A.5    Thabut, D.6    Devers, L.7    Hainque, B.8    Mercadier, A.9    Poynard, T.10
  • 32
    • 54949125767 scopus 로고    scopus 로고
    • Noninvasive assessment of liver fibrosis: Serum markers, imaging, and other modalities
    • Guha, I. N.; Rosenberg, W. M. Noninvasive assessment of liver fibrosis: serum markers, imaging, and other modalities Clin. Liver Dis. 2008, 12 (4) 883-900
    • (2008) Clin. Liver Dis. , vol.12 , Issue.4 , pp. 883-900
    • Guha, I.N.1    Rosenberg, W.M.2
  • 33
    • 0036463681 scopus 로고    scopus 로고
    • Metabonomics: A platform for studying drug toxicity and gene function
    • Nicholson, J. K.; Connelly, J.; Lindon, J. C.; Holmes, E. Metabonomics: a platform for studying drug toxicity and gene function Nat. Rev. Drug Discovery 2002, 1 (2) 153-61
    • (2002) Nat. Rev. Drug Discovery , vol.1 , Issue.2 , pp. 153-61
    • Nicholson, J.K.1    Connelly, J.2    Lindon, J.C.3    Holmes, E.4
  • 34
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson, J. K.; Lindon, J. C.; Holmes, E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 1999, 29 (11) 1181-9
    • (1999) Xenobiotica , vol.29 , Issue.11 , pp. 1181-9
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 38
    • 27144452891 scopus 로고    scopus 로고
    • Systems toxicology: Applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology
    • Heijne, W. H.; Kienhuis, A. S.; van Ommen, B.; Stierum, R. H.; Groten, J. P. Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology Expert Rev. Proteomics 2005, 2 (5) 767-80
    • (2005) Expert Rev. Proteomics , vol.2 , Issue.5 , pp. 767-80
    • Heijne, W.H.1    Kienhuis, A.S.2    Van Ommen, B.3    Stierum, R.H.4    Groten, J.P.5
  • 40
    • 75649149891 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis, animal models, and biomarkers: what is new?; Humana Press: Totowa, NJ,; Vol., pp - 36.
    • Ariz, U.; Mato, J. M.; Lu, S. C.; Martinez Chantar, M. L. Nonalcoholic steatohepatitis, animal models, and biomarkers: what is new? Methods in Molecular Biology; Humana Press: Totowa, NJ, 2010; Vol. 593, pp 109 - 36.
    • (2010) Methods in Molecular Biology , vol.593 , pp. 109
    • Ariz, U.1    Mato, J.M.2    Lu, S.C.3    Martinez Chantar, M.L.4
  • 42
    • 0031066188 scopus 로고    scopus 로고
    • Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products
    • Kotb, M.; Mudd, S. H.; Mato, J. M.; Geller, A. M.; Kredich, N. M.; Chou, J. Y.; Cantoni, G. L. Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products Trends Genet 1997, 13 (2) 51-2
    • (1997) Trends Genet , vol.13 , Issue.2 , pp. 51-2
    • Kotb, M.1    Mudd, S.H.2    Mato, J.M.3    Geller, A.M.4    Kredich, N.M.5    Chou, J.Y.6    Cantoni, G.L.7
  • 46
    • 36849084656 scopus 로고    scopus 로고
    • Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine
    • Finkelstein, J. D. Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine Clin. Chem. Lab. Med. 2007, 45 (12) 1694-9
    • (2007) Clin. Chem. Lab. Med. , vol.45 , Issue.12 , pp. 1694-9
    • Finkelstein, J.D.1
  • 47
    • 0016636377 scopus 로고
    • Alteration of glycine N-methyltransferase activity in fetal, adult, and tumor tissues
    • Heady, J. E.; Kerr, S. J. Alteration of glycine N-methyltransferase activity in fetal, adult, and tumor tissues Cancer Res. 1975, 35 (3) 640-3
    • (1975) Cancer Res. , vol.35 , Issue.3 , pp. 640-3
    • Heady, J.E.1    Kerr, S.J.2
  • 48
    • 2442675553 scopus 로고    scopus 로고
    • Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway
    • Chen, S. Y.; Lin, J. R.; Darbha, R.; Lin, P.; Liu, T. Y.; Chen, Y. M. Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway Cancer Res. 2004, 64 (10) 3617-23
    • (2004) Cancer Res. , vol.64 , Issue.10 , pp. 3617-23
    • Chen, S.Y.1    Lin, J.R.2    Darbha, R.3    Lin, P.4    Liu, T.Y.5    Chen, Y.M.6
  • 49
    • 33745176624 scopus 로고    scopus 로고
    • A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme
    • Luka, Z.; Capdevila, A.; Mato, J. M.; Wagner, C. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme Transgenic Res. 2006, 15 (3) 393-7
    • (2006) Transgenic Res. , vol.15 , Issue.3 , pp. 393-7
    • Luka, Z.1    Capdevila, A.2    Mato, J.M.3    Wagner, C.4
  • 52
    • 41149178478 scopus 로고    scopus 로고
    • HG; Wilson, ID, LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics
    • Theodoridis, G. G. HG; Wilson, ID, LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics Trends Anal. Chem. 2008, 27 (3) 238-50
    • (2008) Trends Anal. Chem. , vol.27 , Issue.3 , pp. 238-50
    • Theodoridis, G.G.1
  • 53
    • 41049099137 scopus 로고    scopus 로고
    • L.W., Current and emerging mass-spectrometry technologies for metabolomics
    • Bedair, M. S. L.W., Current and emerging mass-spectrometry technologies for metabolomics Trends Anal. Chem. 2008, 27 (3) 251-60
    • (2008) Trends Anal. Chem. , vol.27 , Issue.3 , pp. 251-60
    • Bedair, M.S.1
  • 56
    • 34249335649 scopus 로고    scopus 로고
    • OPLS discriminant analysis: Combining the stregths of PLS-DA and SIMCA classification
    • Bylesoö, M. OPLS discriminant analysis: combining the stregths of PLS-DA and SIMCA classification J. Chemometrics 2006, 20, 341-51
    • (2006) J. Chemometrics , vol.20 , pp. 341-51
    • Bylesoö, M.1
  • 57
    • 41149120242 scopus 로고    scopus 로고
    • Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models
    • Wiklund, S.; Johansson, E.; Sjostrom, L.; Mellerowicz, E. J.; Edlund, U.; Shockcor, J. P.; Gottfries, J.; Moritz, T.; Trygg, J. Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models Anal. Chem. 2008, 80 (1) 115-22
    • (2008) Anal. Chem. , vol.80 , Issue.1 , pp. 115-22
    • Wiklund, S.1    Johansson, E.2    Sjostrom, L.3    Mellerowicz, E.J.4    Edlund, U.5    Shockcor, J.P.6    Gottfries, J.7    Moritz, T.8    Trygg, J.9
  • 58
    • 0030962474 scopus 로고    scopus 로고
    • Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry
    • Brugger, B.; Erben, G.; Sandhoff, R.; Wieland, F. T.; Lehmann, W. D. Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry Proc. Natl. Acad. Sci. U.S.A. 1997, 94 (6) 2339-44
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , Issue.6 , pp. 2339-44
    • Brugger, B.1    Erben, G.2    Sandhoff, R.3    Wieland, F.T.4    Lehmann, W.D.5
  • 59
    • 0034582194 scopus 로고    scopus 로고
    • Electrospray ionization mass spectrometry of lysoglycerophosphocholine lipid subclasses
    • Khaselev, N.; Murphy, R. C. Electrospray ionization mass spectrometry of lysoglycerophosphocholine lipid subclasses J. Am. Soc. Mass Spectrom. 2000, 11 (4) 283-91
    • (2000) J. Am. Soc. Mass Spectrom. , vol.11 , Issue.4 , pp. 283-91
    • Khaselev, N.1    Murphy, R.C.2
  • 60
    • 0001099354 scopus 로고    scopus 로고
    • Structural Determination of Lysophospholipid Regioisomers by Electrospray Ionization Tandem Mass Spectrometry
    • Han, X. G. R. W. Structural Determination of Lysophospholipid Regioisomers by Electrospray Ionization Tandem Mass Spectrometry J. Am. Chem. Soc. 1996, 118, 451-57
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 451-57
    • Han, X.G.R.W.1
  • 61
    • 10844283577 scopus 로고    scopus 로고
    • Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3
    • Houjou, T.; Yamatani, K.; Nakanishi, H.; Imagawa, M.; Shimizu, T.; Taguchi, R. Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3 Rapid Commun. Mass Spectrom. 2004, 18 (24) 3123-30
    • (2004) Rapid Commun. Mass Spectrom. , vol.18 , Issue.24 , pp. 3123-30
    • Houjou, T.1    Yamatani, K.2    Nakanishi, H.3    Imagawa, M.4    Shimizu, T.5    Taguchi, R.6
  • 62
    • 0023902956 scopus 로고
    • S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis
    • Duce, A. M.; Ortiz, P.; Cabrero, C.; Mato, J. M. S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis Hepatology 1988, 8 (1) 65-8
    • (1988) Hepatology , vol.8 , Issue.1 , pp. 65-8
    • Duce, A.M.1    Ortiz, P.2    Cabrero, C.3    Mato, J.M.4
  • 63
    • 33845676630 scopus 로고    scopus 로고
    • Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway
    • Kharbanda, K. K.; Mailliard, M. E.; Baldwin, C. R.; Beckenhauer, H. C.; Sorrell, M. F.; Tuma, D. J. Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway J. Hepatol. 2007, 46 (2) 314-21
    • (2007) J. Hepatol. , vol.46 , Issue.2 , pp. 314-21
    • Kharbanda, K.K.1    Mailliard, M.E.2    Baldwin, C.R.3    Beckenhauer, H.C.4    Sorrell, M.F.5    Tuma, D.J.6
  • 65
    • 33646121972 scopus 로고    scopus 로고
    • The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
    • Li, Z.; Agellon, L. B.; Allen, T. M.; Umeda, M.; Jewell, L.; Mason, A.; Vance, D. E. The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis Cell Metab. 2006, 3 (5) 321-31
    • (2006) Cell Metab. , vol.3 , Issue.5 , pp. 321-31
    • Li, Z.1    Agellon, L.B.2    Allen, T.M.3    Umeda, M.4    Jewell, L.5    Mason, A.6    Vance, D.E.7
  • 66
    • 0019639350 scopus 로고
    • Low serum creatine kinase activity in patients with alcoholic liver disease
    • Nanji, A. A.; Blank, D. Low serum creatine kinase activity in patients with alcoholic liver disease Clin. Chem. 1981, 27 (11) 1954
    • (1981) Clin. Chem. , vol.27 , Issue.11 , pp. 1954
    • Nanji, A.A.1    Blank, D.2
  • 69
    • 48649110854 scopus 로고    scopus 로고
    • The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
    • Gentile, C. L.; Pagliassotti, M. J. The role of fatty acids in the development and progression of nonalcoholic fatty liver disease J. Nutr. Biochem. 2008, 19 (9) 567-76
    • (2008) J. Nutr. Biochem. , vol.19 , Issue.9 , pp. 567-76
    • Gentile, C.L.1    Pagliassotti, M.J.2
  • 71
    • 63249121641 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    • Kotronen, A.; Seppanen-Laakso, T.; Westerbacka, J.; Kiviluoto, T.; Arola, J.; Ruskeepaa, A. L.; Oresic, M.; Yki-Jarvinen, H. Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver Diabetes 2009, 58 (1) 203-8
    • (2009) Diabetes , vol.58 , Issue.1 , pp. 203-8
    • Kotronen, A.1    Seppanen-Laakso, T.2    Westerbacka, J.3    Kiviluoto, T.4    Arola, J.5    Ruskeepaa, A.L.6    Oresic, M.7    Yki-Jarvinen, H.8
  • 72
    • 73449095236 scopus 로고    scopus 로고
    • Lipidomic dissection of nonalcoholic steatohepatitis: Moving beyond foie gras to fat traffic
    • Bass, N. M. Lipidomic dissection of nonalcoholic steatohepatitis: moving beyond foie gras to fat traffic Hepatology 2010, 51 (1) 4-7
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 4-7
    • Bass, N.M.1
  • 73
    • 45849112141 scopus 로고    scopus 로고
    • Endocannabinoids and liver disease. IV. Endocannabinoid involvement in obesity and hepatic steatosis
    • Kunos, G.; Osei-Hyiaman, D. Endocannabinoids and liver disease. IV. Endocannabinoid involvement in obesity and hepatic steatosis Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 294 (5) G1101-4
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.294 , Issue.5 , pp. 1101-4
    • Kunos, G.1    Osei-Hyiaman, D.2
  • 74
    • 0034739463 scopus 로고    scopus 로고
    • The expanding superfamily of phospholipase A(2) enzymes: Classification and characterization
    • Six, D. A.; Dennis, E. A. The expanding superfamily of phospholipase A(2) enzymes: classification and characterization Biochim. Biophys. Acta 2000, 1488 (1-2) 1-19
    • (2000) Biochim. Biophys. Acta , vol.1488 , Issue.1-2 , pp. 1-19
    • Six, D.A.1    Dennis, E.A.2
  • 76
    • 0024234475 scopus 로고
    • Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7
    • Leslie, C. C.; Voelker, D. R.; Channon, J. Y.; Wall, M. M.; Zelarney, P. T. Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7 Biochim. Biophys. Acta 1988, 963 (3) 476-92
    • (1988) Biochim. Biophys. Acta , vol.963 , Issue.3 , pp. 476-92
    • Leslie, C.C.1    Voelker, D.R.2    Channon, J.Y.3    Wall, M.M.4    Zelarney, P.T.5
  • 77
    • 0025810578 scopus 로고
    • A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP
    • Clark, J. D.; Lin, L. L.; Kriz, R. W.; Ramesha, C. S.; Sultzman, L. A.; Lin, A. Y.; Milona, N.; Knopf, J. L. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP Cell 1991, 65 (6) 1043-51
    • (1991) Cell , vol.65 , Issue.6 , pp. 1043-51
    • Clark, J.D.1    Lin, L.L.2    Kriz, R.W.3    Ramesha, C.S.4    Sultzman, L.A.5    Lin, A.Y.6    Milona, N.7    Knopf, J.L.8
  • 78
    • 0029587744 scopus 로고
    • Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum
    • Schievella, A. R.; Regier, M. K.; Smith, W. L.; Lin, L. L. Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum J. Biol. Chem. 1995, 270 (51) 30749-54
    • (1995) J. Biol. Chem. , vol.270 , Issue.51 , pp. 30749-54
    • Schievella, A.R.1    Regier, M.K.2    Smith, W.L.3    Lin, L.L.4
  • 79
    • 10344233226 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, v or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cells
    • Pawliczak, R.; Logun, C.; Madara, P.; Lawrence, M.; Woszczek, G.; Ptasinska, A.; Kowalski, M. L.; Wu, T.; Shelhamer, J. H. Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cells J. Biol. Chem. 2004, 279 (47) 48550-61
    • (2004) J. Biol. Chem. , vol.279 , Issue.47 , pp. 48550-61
    • Pawliczak, R.1    Logun, C.2    Madara, P.3    Lawrence, M.4    Woszczek, G.5    Ptasinska, A.6    Kowalski, M.L.7    Wu, T.8    Shelhamer, J.H.9
  • 80
    • 1842558267 scopus 로고    scopus 로고
    • Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2
    • Leslie, C. C. Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2 Prostaglandins Leukot. Essent. Fatty Acids 2004, 70 (4) 373-6
    • (2004) Prostaglandins Leukot. Essent. Fatty Acids , vol.70 , Issue.4 , pp. 373-6
    • Leslie, C.C.1
  • 81
    • 16644382118 scopus 로고    scopus 로고
    • Regulatory mechanism and physiological role of cytosolic phospholipase A2
    • Hirabayashi, T.; Murayama, T.; Shimizu, T. Regulatory mechanism and physiological role of cytosolic phospholipase A2 Biol. Pharm. Bull. 2004, 27 (8) 1168-73
    • (2004) Biol. Pharm. Bull. , vol.27 , Issue.8 , pp. 1168-73
    • Hirabayashi, T.1    Murayama, T.2    Shimizu, T.3
  • 82
    • 0035023432 scopus 로고    scopus 로고
    • Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids
    • Goetzl, E. J. Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids Prostaglandins Other Lipid Mediat. 2001, 64 (1-4) 11-20
    • (2001) Prostaglandins Other Lipid Mediat. , vol.64 , Issue.1-4 , pp. 11-20
    • Goetzl, E.J.1
  • 84
    • 58149087636 scopus 로고    scopus 로고
    • Bile acids metabonomic study on the CCl4- and alpha- naphthylisothiocyanate-induced animal models: Quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry
    • Yang, L.; Xiong, A.; He, Y.; Wang, Z.; Wang, C.; Li, W.; Hu, Z. Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry Chem. Res. Toxicol. 2008, 21 (12) 2280-8
    • (2008) Chem. Res. Toxicol. , vol.21 , Issue.12 , pp. 2280-8
    • Yang, L.1    Xiong, A.2    He, Y.3    Wang, Z.4    Wang, C.5    Li, W.6    Hu, Z.7
  • 86
    • 65649124573 scopus 로고    scopus 로고
    • Bile-acid-induced cell injury and protection
    • Perez, M. J.; Briz, O. Bile-acid-induced cell injury and protection World J. Gastroenterol. 2009, 15 (14) 1677-89
    • (2009) World J. Gastroenterol. , vol.15 , Issue.14 , pp. 1677-89
    • Perez, M.J.1    Briz, O.2
  • 87
    • 0041764976 scopus 로고    scopus 로고
    • Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC)
    • Gilat, T.; Leikin-Frenkel, A.; Goldiner, I.; Juhel, C.; Lafont, H.; Gobbi, D.; Konikoff, F. M. Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC) Hepatology 2003, 38 (2) 436-42
    • (2003) Hepatology , vol.38 , Issue.2 , pp. 436-42
    • Gilat, T.1    Leikin-Frenkel, A.2    Goldiner, I.3    Juhel, C.4    Lafont, H.5    Gobbi, D.6    Konikoff, F.M.7
  • 88
    • 0036753561 scopus 로고    scopus 로고
    • A monoclonal antibody-based enzyme-linked immunosorbent assay of glycolithocholic acid sulfate in human urine for liver function test
    • Kobayashi, N.; Katsumata, H.; Uto, Y.; Goto, J.; Niwa, T.; Kobayashi, K.; Mizuuchi, Y. A monoclonal antibody-based enzyme-linked immunosorbent assay of glycolithocholic acid sulfate in human urine for liver function test Steroids 2002, 67 (10) 827-33
    • (2002) Steroids , vol.67 , Issue.10 , pp. 827-33
    • Kobayashi, N.1    Katsumata, H.2    Uto, Y.3    Goto, J.4    Niwa, T.5    Kobayashi, K.6    Mizuuchi, Y.7
  • 89
    • 2142657911 scopus 로고    scopus 로고
    • Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis
    • Mari, M.; Colell, A.; Morales, A.; Paneda, C.; Varela-Nieto, I.; Garcia-Ruiz, C.; Fernandez-Checa, J. C. Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis J. Clin. Invest. 2004, 113 (6) 895-904
    • (2004) J. Clin. Invest. , vol.113 , Issue.6 , pp. 895-904
    • Mari, M.1    Colell, A.2    Morales, A.3    Paneda, C.4    Varela-Nieto, I.5    Garcia-Ruiz, C.6    Fernandez-Checa, J.C.7
  • 90
    • 34047231082 scopus 로고    scopus 로고
    • Sphingolipid signalling and liver diseases
    • Mari, M.; Fernandez-Checa, J. C. Sphingolipid signalling and liver diseases Liver Int. 2007, 27 (4) 440-50
    • (2007) Liver Int. , vol.27 , Issue.4 , pp. 440-50
    • Mari, M.1    Fernandez-Checa, J.C.2
  • 92
    • 1442333287 scopus 로고    scopus 로고
    • Plasmalogens: Targets for oxidants and major lipophilic antioxidants
    • Engelmann, B. Plasmalogens: targets for oxidants and major lipophilic antioxidants Biochem. Soc. Trans. 2004, 32 (Pt 1) 147-50
    • (2004) Biochem. Soc. Trans. , vol.32 , Issue.PART 1 , pp. 147-50
    • Engelmann, B.1
  • 93
    • 0033559438 scopus 로고    scopus 로고
    • Plasmalogens as endogenous antioxidants: Somatic cell mutants reveal the importance of the vinyl ether
    • Zoeller, R. A.; Lake, A. C.; Nagan, N.; Gaposchkin, D. P.; Legner, M. A.; Lieberthal, W. Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether Biochem. J. 1999, 338 (Pt 3) 769-76
    • (1999) Biochem. J. , vol.338 , Issue.PART 3 , pp. 769-76
    • Zoeller, R.A.1    Lake, A.C.2    Nagan, N.3    Gaposchkin, D.P.4    Legner, M.A.5    Lieberthal, W.6
  • 95
    • 77949444189 scopus 로고    scopus 로고
    • Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat
    • Xie, Z.; Li, H.; Wang, K.; Lin, J.; Wang, Q.; Zhao, G.; Jia, W.; Zhang, Q. Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat Metabolism 2010, 59 (4) 554-60
    • (2010) Metabolism , vol.59 , Issue.4 , pp. 554-60
    • Xie, Z.1    Li, H.2    Wang, K.3    Lin, J.4    Wang, Q.5    Zhao, G.6    Jia, W.7    Zhang, Q.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.