Translational neuroscience approaches to hyperphagia

Journal of Neuroscience

Volumn 30, Issue 35, 2010, Pages 11549-11554

  Perello, Mario ^a   Chuang, Jen Chieh ^a   Scott, Michael M ^a   Lutter, Michael ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; GENETICS; HUMAN; HYPERPHAGIA; NEUROSCIENCE; PROCEDURES; TRANSLATIONAL RESEARCH; TRENDS;

ANIMALS; HUMANS; HYPERPHAGIA; NEUROSCIENCES; TRANSLATIONAL MEDICAL RESEARCH;

EID: 77956295857     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2578-10.2010     Document Type: Review

References (70)

1. Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 116:3229-3239. (Pubitemid 44878637)
2. Adan RA, Tiesjema B, Hillebrand JJ, la Fleur SE, Kas MJ, de Krom M (2006) The MC4 receptor and control of appetite. Br J Pharmacol 149:815-827.
3. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, Ed 4. Washington, DC: American Psychiatric Association.
4. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB (2005) Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123:493-505.
5. Batterham RL, ffytche DH, Rosenthal JM, Zelaya FO, Barker GJ, Withers DJ, Williams SC (2007) PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 450:106-109.
6. Berridge KC (2009) 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders. Physiol Behav 97:537-550.
7. Bizzarri C, Rigamonti AE, Luce A, Cappa M, Cella SG, Berini J, Sartorio A, Müller EE, Salvatoni A (2010) Children with Prader-Willi syndrome exhibit more evident meal-induced responses in plasma ghrelin and peptide YY levels than obese and lean children. Eur J Endocrinol 162:499-505.
8. Bragulat V, Dzemidzic M, Bruno C, Cox CA, Talavage T, Considine RV, Kareken DA (2010) Food-related odor probes of brain reward circuits during hunger: a pilot fMRI study. Obesity (Silver Spring) 18:1566-1571.
9. Branson R, Potoczna N, Kral JG, Lentes KU, Hoehe MR, Horber FF (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 348: 1096-1103. (Pubitemid 36337320)
10. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN (2008) An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 359:2558-2566.
11. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS (2002) Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med 8:643-644. (Pubitemid 34778697)
12. Davis CA, Levitan RD, Reid C, Carter JC, Kaplan AS, Patte KA, King N, Curtis C, Kennedy JL (2009) Dopamine for "wanting" and opioids for "liking": a comparison of obese adults with and without binge eating. Obesity (Silver Spring) 17:1220-1225.
13. de Castro JM (2000) Eating behavior: lessons from the real world of humans. Nutrition 16:800-813.
14. DelParigi A, Tschöp M, Heiman ML, Salbe AD, Vozarova B, Sell SM, Bunt JC, Tataranni PA (2002) High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader-Willi syndrome. J Clin Endocrinol Metab 87:5461-5464. (Pubitemid 36034344)
15. De Waele K, Ishkanian SL, Bogarin R, Miranda CA, Ghatei MA, Bloom SR, Pacaud D, Chanoine JP (2008) Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader-Willi syndrome. Eur J Endocrinol 159:381-388.
16. Dimitropoulos A, Schultz RT (2008) Food-related neural circuitry in Prader-Willi syndrome: response to high-versus low-calorie foods. J Autism Dev Disord 38:1642-1653.
17. Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39:724-726.
18. Elias CF, Kelly JF, Lee CE, Ahima RS, Drucker DJ, Saper CB, Elmquist JK (2000) Chemical characterization of leptin-activated neurons in the rat brain. J Comp Neurol 423:261-281.
19. Erlanson-Albertsson C (2005) How palatable food disrupts appetite regulation. Basic Clin Pharmacol Toxicol 97:61-73.
20. Farooqi IS, Yeo GS, O'Rahilly S (2003a) Binge eating as a phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 349:606-609; author reply 606-609.
21. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S (2003b) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085-1095. (Pubitemid 36337319)
22. Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, Fletcher PC (2007) Leptin regulates striatal regions and human eating behavior. Science 317:1355.
23. Feigerlová E, Diene G, Conte-Auriol F, Molinas C, Gennero I, Salles JP, Arnaud C, Tauber M (2008) Hyperghrelinemia precedes obesity in Prader-Willi syndrome. J Clin Endocrinol Metab 93:2800-2805. (Pubitemid 352008554)
24. Felsted JA, Ren X, Chouinard-Decorte F, Small DM (2010) Genetically determined differences in brain response to a primary food reward. J Neurosci 30:2428-2432.
25. Finlayson G, King N, Blundell JE (2007) Is it possible to dissociate 'liking' and 'wanting' for foods in humans? A novel experimental procedure. Physiol Behav 90:36-42.
26. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894.
27. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318:1469-1472. (Pubitemid 350208961)
28. Glass MJ, Billington CJ, Levine AS (1999) Opioids and food intake: distributed functional neural pathways? Neuropeptides 33:360-368.
29. Goldstone AP (2004) Prader-Willi syndrome: advances in genetics, pathophysiology and treatment. Trends Endocrinol Metab 15:12-20. (Pubitemid 38198094)
30. Gotoda T (2003) Binge eating as a phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 349:606-609; author reply 606-609.
31. Gunay-Aygun M, Schwartz S, Heeger S, O'Riordan MA, Cassidy SB (2001) The changing purpose of Prader-Willi syndrome clinical diagnostic criteria and proposed revised criteria. Pediatrics 108:E92.
32. Haqq AM, Grambow SC, Muehlbauer M, Newgard CB, Svetkey LP, Carrel AL, Yanovski JA, Purnell JQ, Freemark M (2008) Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development. Clin Endocrinol (Oxf) 69:911-920.
33. Haupt A, Thamer C, Staiger H, Tschritter O, Kirchhoff K, Machicao F, Häring HU, Stefan N, Fritsche A (2009) Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes 117:194-197.
34. Hebebrand J, Geller F, Dempfle A, Heinzel- Gutenbrunner M, Raab M, Gerber G, Wermter AK, Horro FF, Blundell J, Schäfer H, Remschmidt H, Herpertz S, Hinney A (2004) Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. Mol Psychiatry 9:796-800. (Pubitemid 39107968)
35. Herpertz S, Siffert W, Hebebrand J (2003) Binge eating as a phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 349: 606-609; author reply 606-609.
36. Herzig V, Capuani EM, Kovar KA, Schmidt WJ (2005) Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats. Addict Biol 10:243-249.
37. Hinney A, Vogel CI, Hebebrand J (2010) From monogenic to polygenic obesity: recent advances. Eur Child Adolesc Psychiatry 19:297-310.
38. Holsen LM, Zarcone JR, Brooks WM, Butler MG, Thompson TI, Ahluwalia JS, Nollen NL, Savage CR (2006) Neural mechanisms underlying hyperphagia in Prader-Willi syndrome. Obesity (Silver Spring) 14:1028-1037. (Pubitemid 46219704)
39. Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ (2006) Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 51:801-810. (Pubitemid 44374908)
40. Jarosz PA, Kessler JT, Sekhon P, Coscina DV (2007) Conditioned place preferences (CPPs) to high-caloric "snack foods" in rat strains genetically prone vs. resistant to diet-induced obesity: resistance to naltrexone blockade. Pharmacol Biochem Behav 86:699-704.
41. Jimerson DC, Mantzoros C, Wolfe BE, Metzger ED (2000) Decreased serum leptin in bulimia nervosa. J Clin Endocrinol Metab 85: 4511-4514. (Pubitemid 32157625)
42. Johnson PM, Kenny PJ (2010) Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 13:635-641.
43. Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S Jr, Diano S, Horvath TL, Seeley RJ, Becker JB, Münzberg H, Myers MG Jr (2009) Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab 10:89-98.
44. Lowe MR, Butryn ML, Didie ER, Annunziato RA, Thomas JG, Crerand CE, Ochner CN, Coletta MC, Bellace D, Wallaert M, Halford J (2009) The power of food scale. A new measure of the psychological influence of the food environment. Appetite 53:114-118.
45. Lutter M, Nestler EJ (2009) Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr 139:629-632.
46. Malik S, McGlone F, Bedrossian D, Dagher A (2008) Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 7:400-409. (Pubitemid 351598026)
47. Marsh R, Steinglass JE, Gerber AJ, Graziano O'Leary K, Wang Z, Murphy D, Walsh BT, Peterson BS (2009) Deficient activity in the neural systems that mediate self-regulatory control in bulimia nervosa. Arch Gen Psychiatry 66:51-63.
48. Miller JL, James GA, Goldstone AP, Couch JA, He G, Driscoll DJ, Liu Y (2007) Enhanced activation of reward mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome. J Neurol Neurosurg Psychiatry 78:615-619. (Pubitemid 46853897)
49. Monteleone P, Di Lieto A, Tortorella A, Longobardi N, Maj M (2000) Circulating leptin in patients with anorexia nervosa, bulimia nervosa or binge-eating disorder: relationship to body weight, eating patterns, psychopathology and endocrine changes. Psychiatry Res 94:121-129. (Pubitemid 30243099)
50. Naleid AM, Grace MK, Chimukangara M, Billington CJ, Levine AS (2007) Paraventricular opioids alter intake of high-fat but not high-sucrose diet depending on diet preference in a binge model of feeding. Am J Physiol Regul Integr Comp Physiol 293:R99-R105. (Pubitemid 47092167)
51. Nasser JA, Evans SM, Geliebter A, Pi-Sunyer FX, Foltin RW (2008) Use of an operant task to estimate food reinforcement in adult humans with and without BED. Obesity (Silver Spring) 16:1816-1820.
52. Ogawa S, Lee TM, Nayak AS, Glynn P (1990) Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14:68-78. (Pubitemid 20243866)
53. Olausson P, Jentsch JD, Tronson N, Neve RL, Nestler EJ, Taylor JR (2006) DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J Neurosci 26:9196-9204. (Pubitemid 44359846)
54. Olszewski PK, Fredriksson R, Olszewska AM, Stephansson O, Alsiö J, Radomska KJ, Levine AS, Schiöth HB (2009) Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci 10:129.
55. Pelchat ML, Johnson A, Chan R, Valdez J, Ragland JD (2004) Images of desire: food-craving activation during fMRI. Neuroimage 23:1486-1493. (Pubitemid 40260371)
56. Perello M, Sakata I, Birnbaum S, Chuang JC, Osborne-Lawrence S, Rovinsky SA, Woloszyn J, Yanagisawa M, Lutter M, Zigman JM (2010) Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biol Psychiatry 67:880-886.
57. Sanders AC, Hussain AJ, Hen R, Zhuang X (2007) Chronic blockade or constitutive deletion of the serotonin transporter reduces operant responding for food reward. Neuropsychopharmacology 32:2321-2329. (Pubitemid 47587680)
58. Schienle A, Schäfer A, Hermann A, Vaitl D (2009) Binge-eating disorder: reward sensitivity and brain activation to images of food. Biol Psychiatry 65:654-661.
59. Speakman JR, Rance KA, Johnstone AM (2008) Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 16:1961-1965.
60. Tan TM, Vanderpump M, Khoo B, Patterson M, Ghatei MA, Goldstone AP (2004) Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome. J Clin Endocrinol Metab 89:4162-4165. (Pubitemid 39071530)
61. Timpson NJ, Emmett PM, Frayling TM, Rogers I, Hattersley AT, McCarthy MI, Davey Smith G (2008) The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr 88:971-978.
62. Treasure J, Claudino AM, Zucker N (2010) Eating disorders. Lancet 375:583-593.
63. Uher R, Murphy T, Brammer MJ, Dalgleish T, Phillips ML, Ng VW, Andrew CM, Williams SC, Campbell IC, Treasure J (2004) Medial prefrontal cortex activity associated with symptom provocation in eating disorders. Am J Psychiatry 161:1238-1246. (Pubitemid 38859174)
64. Vaughan C, Moore M, Haskell-Luevano C, Rowland NE (2006) Food motivated behavior of melanocortin-4 receptor knockout mice under a progressive ratio schedule. Peptides 27:2829-2835. (Pubitemid 44584424)
65. Wagner A, Aizenstein H, Venkatraman VK, Bischoff-Grethe A, Fudge J, May JC, Frank GK, Bailer UF, Fischer L, Putnam K, Kaye WH (2010) Altered striatal response to reward in bulimia nervosa after recovery. Int J Eat Disord 43:289-294.
66. Wardle J, Guthrie CA, Sanderson S, Rapoport L (2001) Development of the Children's Eating Behaviour Questionnaire. J Child Psychol Psychiatry 42:963-970. (Pubitemid 33009378)
67. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R (2008) Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 93:3640-3643.
68. Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S (1998) A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20:111-112. (Pubitemid 28455438)
69. Yonghui L, Xigeng Z, Yunjing B, Xiaoyan Y, Nan S (2006) Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats. J Psychopharmacol 20:40-46.
70. Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK (2006) Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 494:528-548. (Pubitemid 41791000)