Hyperghrelinemia precedes obesity in Prader-Willi syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 7, 2008, Pages 2800-2805

  Feigerlová, Eva ^a   Diene, Gwenaëlle ^a   Conte Auriol, Françoise ^a,c   Molinas, Catherine ^a   Gennero, Isabelle ^b   Salles, Jean Pierre ^a,c   Arnaud, Catherine ^d   Tauber, Maïthé ^a,c,d,e  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b CHU PURPAN   (France)

^c INSERM   (France)

^d UNIVERSITÉ DE TOULOUSE   (France)

^e HÔPITAL DES ENFANTS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GROWTH HORMONE; INSULIN; LEPTIN;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GHRELIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; MALE; OBESITY; PRADER WILLI SYNDROME; PRIORITY JOURNAL; SCORING SYSTEM; STATISTICAL SIGNIFICANCE;

EID: 47549096062     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-2138     Document Type: Article

References (41)

1. Prader A, Labhart A, Willi H 1956 Ein syndrom von adipositas, kryptorchismus und oligophrenie nach myatonieartigem zustand in neugeborenenamter. Schweiz Med Wochenschr 86:1260-1261
2. Holm VA, Cassidy SB, Butler MG, Hanchett JM, Greenswag LR, Whitman BY, Greenberg F 1993 Prader-Willi syndrome: consensus diagnostic criteria. Pediatrics 91:398-402
3. Gunay-Aygun M, Schwartz S, Heeger S, O'Riordan MA, Cassidy SB 2001 The changing purpose of Prader-Willi syndrome clinical diagnosis criteria and proposed revised criteria. Pediatrics 108:E92
4. Glenn CC, Driscoll DJ, Yang TP, Nicholls RD 1997 Genomic imprinting: potential function and mechanisms revealed by the Prader-Willi and Angelman syndromes. Mol Hum Reprod 3:321-332
5. Nicholls RD, Saitoh S, Horsthemke B 1998 Imprinting in Prader-Willi and Angelman syndromes. Trends Genet 14:194-200
6. Bacheré N, Diene G, Delagnes V, Molinas C, Moulin P, Tauber M 2008 Early diagnosis and multidisciplinary care reduce the hospitalisation time and duration of tube feeding and prevent early obesity in PWS infants. Horm Res 69:45-52
7. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
8. Chanoine JP 2005 Ghrelin in growth and development. Horm Res 63:129-138
9. Hosoda H, Kojima M, Kangawa K 2006 Biological, physiological and pharmacological aspects of ghrelin. J Pharmacol Sci 100:398-410
10. Van der Lely AJ, Tschop M, Heiman ML, Chigo E 2004 Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25:426-427
11. Schwartz MW, Mortin GJ 2002 Obesity: keeping hunger at bay. Nature 418:595-597
12. Bouret SG, Draper SJ, Simerly RB 2004 Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304:108-110
13. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS 2002 Elevated plasma ghrelin levels in Prader-Willi syndrome. Nat Med 8:643-644
14. Ha AM, Farooqi IS, O'Rahilly S, Stadler DD, Rosenfeld RG, Pratt KL, LaFranchi SH, Purnell JQ 2003 Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. J Clin Endocrinol Metab 88:174-178
15. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML 2001 Circulating ghrelin levels are decreased in human obesity. Diabetes 50:707-709
16. Tauber M, Conte Auriol F, Moulin P, Molinas C, Delagnes V, Salles JP 2004 Hyperghrelinemia is acommonfeature of Prader-Willi syndrome and pituitary stalk interruption: a pathophysiological hypothesis. Horm Res 62:49-54
17. Burman P, Ritzen ME, Lindgren AC 2001 Endocrine dysfunction in Prader-Willi syndrome: a review with special reference to GH. Endocr Rev 22:787-799
18. Soriano-Guillen L, Barrios V, Chowen JA, Sanchez I, Vila S, Quero J, Argente J 2004 Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures. J Pediatr 144:30-35
19. Whatmore AJ, Hall CM, Jones J, Westwood M, Clayton PE 2003 Ghrelin concentrations in healthy children and adolescents. Clin Endocrinol (Oxf) 59:649-654
20. Goldstone AP, Thomas EL, Brynes AE, Castroman G, Edwards R, Ghatei MA, Frost G, Holland AJ, Grossman AB, Korbonits M, Bloom SR, Bell JD 2004 Elevated fasting plasma ghrelin in Prader-Willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance. J Clin Endocrinol Metab 89:1718-1726
21. Goldstone AP, Patterson M, Kalingag N, Ghatei MA, Brynes AE, Bloom SR, Grossman AB, Korbonits M 2005 Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma. J Clin Endocrinol Metab 90:2681-2690
22. Butler MG, Bittel DC, Talebizadeh Z 2004 Plasma peptide YY and ghrelin levels in infants and children with Prader-Willi syndrome. J Pediatr Endocrinol Metab 2004 17:1177-1184
23. Erdie-Lalena CR, Holm VA, Kelly PC, Frayo RS, Cummings DE 2006 Ghrelin levels in very young children with Prader-Willi syndrome. J Pediatr 149:199-204
24. Rolland-Cachera MF, Cole TJ, Sempe M, Tichet J, Rossignol C, Charraud A 1991 Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr 45:13-21
25. Usher R, Mc Lean F 1969 Intrauterine growth of live-born Caucasian infants at sea level: standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeks of gestation. J Pediatr 74:901-910
26. Svendsen OL, Hassager C, Bergmann I, Christiansen C 1993 Measurement of abdominal and intra-abdominal fat in postmenopausal women by dual energy X-ray absorptiometry anthropometry: Comparison with computerized tomography. Int J Obes Relat Metab Disord 17:45-51
27. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting glucose and insulin concentrations in man. Diabetologia 28:412-419
28. Ariyasu H, Takaya K, Hosoda H, Iwakura H, Ebihara K, Mori K, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K 2002 Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology 143:3341-3350
29. Marzullo P, Verti B, Savia G, Walker GE, Guzzaloni G, Tagliaferri M, Di Blasio A, Liuzzi A 2004 The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure. J Clin Endocrinol Metab 89:936-939
30. Stefan M, Ji H, Simmons RA, Cummings DE, Ahima RS, Friedman MI, Nicholls RD 2005 Hormonal and metabolic defects in a Prader-Willi syndrome mouse model with neonatal failure to thrive. Endocrinology 146:4377-4385
31. Butler MG, Bittel DC 2007 Plasma obestatin and ghrelin levels in subjects with Prader-Willi syndrome. Am J Med Genet 143A:415-421
32. Paik KH, Jin DK, Song SY, Lee JE, Ko SH, Song SM, Kim JS, Oh YJ, Kim SW, Lee SH, Kim SH, Kwon EK, Choe YH 2004 Correlation between fasting plasma ghrelin levels and age, body mass index (BMI), BMI percentiles, and 24-hour plasma ghrelin profiles in Prader-Willi syndrome. J Clin Endocrinol Metab 89:3885-3889
33. Ikezaki A, Hosoda H, Ito K, Iwama S, Miura N, Matsuoka H, Kondo C, Kojima M, Kangawa K, Sugihara S 2002 Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 51:3408-3411
34. McLaughlin T, Abbasi F, Lamendola C, Frayo RS, Cummings DE 2004 Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls. J Clin Endocrinol Metab 89:1630-1635
35. Eiholzer U, Stutz K, Weinmann C, Torresani T, Molinari L, Prader A 1998 Low insulin, IGF-I and IGFBP-3 levels in children with Prader-Labhart-Willi syndrome. Eur J Pediatr. 157:890-893
36. Goldstone AP, Thomas EL, Brynes AE, Bell JD, Frost G, Saeed N, Hajnal JV, Howard JK, Holland A, Bloom SR 2001 Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution. J Clin Endocrinol Metab 86:4330-4338
37. Krochik AG, Ozuna B, Torrado M, Chertkoff L, Mazza C 2006 Characterization of alterations in carbohydrate metabolism in children with Prader-Willi syndrome. J Clin Endocrinol Metab 19:911-918
38. Talebizadeh Z, Butler M 2005 Insulin resistance and obesity-related factors in Prader-Willi syndrome: comparison with obese subjects. Clin Genet 67:230-239
39. Ha AM, Stadler DD, Jackson RH, Rosenfeld RG, Purnell JQ, LaFranchi SH 2003 Effects of growth hormone on pulmonary function, sleep quality, behavior, cognition, growth velocity, body composition, and resting energy expenditure in Prader-Willi syndrome. J Clin Endocrinol Metab 88:2206-2212
40. Hauffa BP, Haase K, Range IM, Unger N, Mann K, Petersenn S 2007 The effect of growth hormone on the response of total and acylated ghrelin to a standardized oral glucose load and insulin resistance in children with Prader-Willi syndrome. J Clin Endocrinol Metab 92:834-840
41. Hoybye C, Barkeling B, Espelund U, Petersson M, Thoren M 2003 Peptides associated with hyperphagia in adults with Prader-Willi syndrome before and during GH treatment. Growth Horm IGF Res 13:322-327