Cavernosal expandability is an erectile tissue mechanical property which predicts trabecular histology in an animal model of vasculogenic erectile dysfunction

Journal of Urology

Volumn 159, Issue 6, 1998, Pages 2229-2236

  Nehra, Ajay ^b   Azadzoi, Kazem M ^b   Moreland, Robert B ^b   Pabby, Ajay ^b   Siroky, Mike B ^b   Krane, Robert J ^b   Goldstein, Irwin ^a   Udelson, Daniel ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Cavernosal expandability; Computer assisted color histomorphometry; Erectile dysfunction; Erectile function; Erectile tissue mechanical property; Hypercholesterolemia; Ischemic induced fibrosis

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOPSY TECHNIQUE; CHOLESTEROL INTAKE; CONTROLLED STUDY; ERECTILE DYSFUNCTION; HISTOPATHOLOGY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PREDICTION; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RABBIT;

EID: 0032426699     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)63311-1     Document Type: Article

References (21)

1. Nehra, A., Goldstein, I, Pabby, A., de las Morenas, A., Udelson, D., Krane, R. J., Saenz de Tejada, I. and Moreland, R. B.: Mechanisms of venous leakage: a clincopathologic correlation of corporeal structure and function. J. Urol., 156: 1320, 1996.
2. Wespes, E., Goes, P. M., Schiffmann, S., Deprierreux, M., Vanderhaeghen, J. J. and Schulman, C. C.: Computerized analysis of smooth muscle fibers in potent and impotent patients. J. Urol., 146: 1015, 1991.
3. Udelson, D., Nehra, A., Hatzichristou, D., Azadzoi, A., Moreland, R. B., Krane, R. J., Saenz de Tejada, I. and Goldstein, I.: Engineering analysis of penile hemodynamic and structural dynamic relationships. I. Clinical implications of penile tissue mechanical properties. Int. J. Impotence Res., 10: 15, 1998.
4. Udelson, D., Nehra, A., Hatzichristou, D., Azadzoi, A., Moreland, R. B., Krane, R. J., Saenz de Tejada, I. and Goldstein, I.: Engineering analysis of penile hemodynamic and structural dynamic relationships. II. Clinical implications of penile buckling. Int. J. Impotence Res., 10: 25, 1998.
5. Udelson, D., Nehra, A., Hatzichristou, D., Azadzoi, A., Moreland, R. B., Krane, R. J., Saenz de Tejada, I. and Goldstein, I.: Engineering analysis of penile hemodynamic and structural dynamic relationships. III. Clinical considerations of penile hemodynamics and rigidity erectile responses. Int. J. Impotence Res., in press.
6. Hatzichristou, D. G. Saenz de Tejada, I., Kupferman, S., Namburi, S., Pescatori, E. S., Udelson, D. and Goldstein I.: In vivo assessment of trabecular smooth muscle tone, its application in pharmacocavernosometry and analysis of intracavernosal pressure determinants. J. Urol., 153: 1126, 1995.
7. Azadzoi, K. M. and Goldstein, I.: Erectile dysfunction due to atherosclerotic vascular disease: the development of an animal model. J. Urol., 147: 1675, 1992.
8. Azadzoi, K. M., Siroky, M. B. and Goldstein I.: Study of etiologic relationship of arterial atherosclerosis to corporal veno-occlusive dysfunction in the rabbit. J. Urol., 155: 1795, 1996.
9. Kim, J. H., Klyachkin, M. L., Svendsen, E., Davies, M. G., Hagen, P. O. and Carson, C. C.: Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J. Urol., 151: 198, 1994.
10. Azadzoi, K. M., Park, K., Andry, C., Goldstein, I. and Siroky, M. B.: Relationship between cavernosal ischemia and corporal veno-occlusive dysfunction in an animal model. J. Urol., 157: 1011, 1997.
11. Conti, G. and Virag, R.: Human penile erection and organic impotence: normal histology and histopathology. Urol. Int., 44: 303, 1989.
12. Andersson, K-E. and Wagner, G.: Physiology of erection. Physiol. Rev., 75: 191, 1995.
13. Persson, C., Diederichs, W., Lue, T. F., Benedict Yen, T. S., Fishman, I. J., McLin, P. H. and Tanagho, E. A.: Correlation of altered penile ultrastructure with clinical arterial evaluation. J. Urol., 142: 1462, 1989.
14. Jevtich, M. J., Khawand, N. Y. and Vidic, B.: Clinical significance of ultrastructural findings in the corpora cavernosa of normal and impotent men. J. Urol., 143: 289, 1990.
15. Nehra, A., Hall, S. J., Basile, O., Bertero, E. B., Moreland, R., Toselli, P., de las Morenas, A. and Goldstein, I.: Systemic sclerosis: a clinicopathological correlation. J. Urol., 153: 1140, 1995.
16. Azadzoi, K. M., Goldstein, I., Krane, R. J. and Siroky, M. B. Ischemia-induced TGF-β1 mediated cavernosal fibrosis is modulated by eicosanoids. Int. J. Imp. Res., 8: 108(Abstract A36), 1996.
17. Cox, R. H. and Deitweiler, D. K.: Arterial wall properties and dietary atherosclerosis in the racing greyhounds. Am J. Physiol., 236: H790, 1979.
18. Shankar, R. and Gene Bond, M.: Correlation of noninvasive arterial compliance with anatomic pathology of atherosclerotic nonhuman primates. Atherosclerosis, 85: 37, 1990.
19. Nichol, J. T.: The effects of cholesterol feeding on the distensibility of the isolated thoracic aorta. Can. J. Biochem. Physiol., 33: 507, 1955.
20. Munarriz, R. M., Yan, R. Q., Nehra, A., Udelson D. and Goldstein, I.: Blunt trauma: the pathophysiology of hemodynamic injury leading to erectile dysfunction. J. Urol., 153: 1831, 1995.
21. Udelson, D., L'Esperance, J., Martin-Morales, A., Patel, R., Daller, M., Sciortino, D. Krane, R. J. and Goldstein, I.: Engineering Analysis of Corporal Veno-occlusion: The Effect of Stretch-Associated Luminal Constrictability on Outflow Resistance. Int. J. Impotence Res., submitted 1998.