Oral administration of an apo A-I mimetic peptide synthesized from D-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol

Circulation

Volumn 105, Issue 3, 2002, Pages 290-292

  Navab, Mohamad ^a   Anantharamaiah, G M ^a   Hama, Susan ^a   Garber, David W ^a   Chaddha, Manjula ^a   Hough, Greg ^a   Lallone, Roger ^a   Fogelman, Alan M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apo A I; Atherosclerosis; HDL; LDL oxidation

Indexed keywords

ACETYLASPARTYLTRYPTOPHANYLPHENYLALANYLLYSYLALANYLPHENYLALANYLTYROSYLASPARTY LLYSYLVALYLALANYLGLUTAMINYLLYSYLPHENYLALANYLLYSYLGLUTAMINYLALANYLPHENYLALANYLAMI DE; ACETYLLEUCYLLYSYLALANYLPHENYLALANYLTYROSYLASPARTYLLYSYLVALYLALANYLGLUTAMINY LLYSYLLEUCYLLYSYLGLUTAMINYLALANYLPHENYLALANINAMIDE; APOLIPOPROTEIN A1; DEXTRO AMINO ACID; DRINKING WATER; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET; DRUG EFFECT; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; URINARY EXCRETION;

ADMINISTRATION, ORAL; AMINO ACIDS; ANIMALS; APOLIPOPROTEIN A-I; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CELLS, CULTURED; CHEMOTAXIS; CHOLESTEROL; COCULTURE TECHNIQUES; FEMALE; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; PEPTIDES; RECEPTORS, LDL;

EID: 0037154287     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc0302.103711     Document Type: Article

References (12)

1. Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit
2. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse
3. milano mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein E-deficient mice: Potential implications for acute plaque stabilization
4. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: Step 1
5. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: Steps 2 and 3
6. HDL and the inflammatory response induced by LDL-derived oxidized phospholipids
7. A new synthetic class A amphipathic peptide analogue protects mice from diet-induced atherosclerosis
8. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis
9. Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide
10. Turnover of synthetic class A amphipathic peptide analogues of exchangeable apolipoproteins in rats: Correlation with physical properties
11. High-density lipoprotein loses its anti-inflammatory properties during acute influenza A infection
12. A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids