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Volumn 178, Issue 1, 2008, Pages 513-526

Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C; TRANSCRIPTION FACTOR DAF 16;

EID: 40849120201     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.107.083253     Document Type: Article
Times cited : (52)

References (47)
  • 1
    • 0037127026 scopus 로고    scopus 로고
    • Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
    • ARANTES-OLIVEIRA, N., J. APFELD, A. DILLIN and C. KENYON, 2002 Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295: 502-505.
    • (2002) Science , vol.295 , pp. 502-505
    • ARANTES-OLIVEIRA, N.1    APFELD, J.2    DILLIN, A.3    KENYON, C.4
  • 3
    • 33644772542 scopus 로고    scopus 로고
    • Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling
    • BERMAN, J. R., and C. KENYON, 2006 Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell 124: 1055-1068.
    • (2006) Cell , vol.124 , pp. 1055-1068
    • BERMAN, J.R.1    KENYON, C.2
  • 4
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • BRENNER, S., 1974 The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • BRENNER, S.1
  • 5
    • 33846436789 scopus 로고    scopus 로고
    • A steroid hormone that extends the lifespan of Caenorhabditis elegans
    • BROUE, F., P. LIERE, C. KENYON and E. E. BAULIEU, 2007 A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell 6: 87-94.
    • (2007) Aging Cell , vol.6 , pp. 87-94
    • BROUE, F.1    LIERE, P.2    KENYON, C.3    BAULIEU, E.E.4
  • 6
    • 34548614737 scopus 로고    scopus 로고
    • Loss of pregnancy-associated plasma protein A extends lifespan in mice
    • CONOVER, C. A., and L. K. BALE, 2007 Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell 6: 727-729.
    • (2007) Aging Cell , vol.6 , pp. 727-729
    • CONOVER, C.A.1    BALE, L.K.2
  • 7
    • 0037174629 scopus 로고    scopus 로고
    • Timing requirements for insulin/IGF-1 signaling in C. elegans
    • DILLIN, A., D. K. CRAWFORD and C. KENYON, 2002 Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830-834.
    • (2002) Science , vol.298 , pp. 830-834
    • DILLIN, A.1    CRAWFORD, D.K.2    KENYON, C.3
  • 8
    • 34547810054 scopus 로고    scopus 로고
    • Quantitative mass spectrometry identifies insulin signaling targets in C. elegans
    • DONG, M.-Q., J. D. VENABLE, N. AU, T. XU, S. K. PARK et al., 2007 Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science 317: 660-663.
    • (2007) Science , vol.317 , pp. 660-663
    • DONG, M.-Q.1    VENABLE, J.D.2    AU, N.3    XU, T.4    PARK, S.K.5
  • 9
    • 0028807085 scopus 로고
    • The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
    • DORMAN, J. B., B. ALBINDER, T. SHROYER and C. KENYON, 1995 The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141: 1399-1406.
    • (1995) Genetics , vol.141 , pp. 1399-1406
    • DORMAN, J.B.1    ALBINDER, B.2    SHROYER, T.3    KENYON, C.4
  • 10
    • 2442565649 scopus 로고    scopus 로고
    • Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans
    • FUJII, M., Y. MATSUMOTO, N. TANAKA, K. MIKI, T. SUZUKI et al., 2004 Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans. J. Biol. Chem. 279: 20277-20282.
    • (2004) J. Biol. Chem , vol.279 , pp. 20277-20282
    • FUJII, M.1    MATSUMOTO, Y.2    TANAKA, N.3    MIKI, K.4    SUZUKI, T.5
  • 11
    • 0034661826 scopus 로고    scopus 로고
    • Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
    • FURUYAMA, T., T. NAKAZAWA, I. NAKANO and N. MORI, 2000 Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349: 629-634.
    • (2000) Biochem. J , vol.349 , pp. 629-634
    • FURUYAMA, T.1    NAKAZAWA, T.2    NAKANO, I.3    MORI, N.4
  • 12
    • 0036021375 scopus 로고    scopus 로고
    • Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation
    • GARIGAN, D., A. L. HSU, A. G. FRASER, R. S. KAMATH, J. AHRINGER et al., 2002 Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161: 1101-1112.
    • (2002) Genetics , vol.161 , pp. 1101-1112
    • GARIGAN, D.1    HSU, A.L.2    FRASER, A.G.3    KAMATH, R.S.4    AHRINGER, J.5
  • 13
    • 0031685525 scopus 로고    scopus 로고
    • Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction, and longevity in Caenorhabditis elegans
    • GEMS, D., A. J. SUTTON, M. L. SUNDERMEYER, P. S. ALBERT, K. V. KING et al., 1998 Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction, and longevity in Caenorhabditis elegans. Genetics 150: 129-155.
    • (1998) Genetics , vol.150 , pp. 129-155
    • GEMS, D.1    SUTTON, A.J.2    SUNDERMEYER, M.L.3    ALBERT, P.S.4    KING, K.V.5
  • 14
    • 0035656274 scopus 로고    scopus 로고
    • A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
    • GERISCH, B., C. WEITZEL, C. KOBER- EISERMANN, V. ROTTIERS and A. ANTEBI, 2001 A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev. Cell 1: 841-851.
    • (2001) Dev. Cell , vol.1 , pp. 841-851
    • GERISCH, B.1    WEITZEL, C.2    KOBER- EISERMANN, C.3    ROTTIERS, V.4    ANTEBI, A.5
  • 15
    • 34247563364 scopus 로고    scopus 로고
    • A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
    • GERISCH, B., V. ROTTIERS, D. LI, D. L. MOTOLA, C. L. CUMMINS et al., 2007 A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 104: 5014-5019.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5014-5019
    • GERISCH, B.1    ROTTIERS, V.2    LI, D.3    MOTOLA, D.L.4    CUMMINS, C.L.5
  • 16
    • 0032981396 scopus 로고    scopus 로고
    • Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene
    • GIL, E. B., E. MALONE LINK, L. X. LIU, C. D. JOHNSON and J. A. LEES, 1999 Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene. Proc. Natl. Acad. Sci. USA 96: 2925-2930.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2925-2930
    • GIL, E.B.1    MALONE LINK, E.2    LIU, L.X.3    JOHNSON, C.D.4    LEES, J.A.5
  • 17
    • 0035846604 scopus 로고    scopus 로고
    • daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • HENDERSON, S. T., and T. E. JOHNSON, 2001 daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11: 1975-1980.
    • (2001) Curr. Biol , vol.11 , pp. 1975-1980
    • HENDERSON, S.T.1    JOHNSON, T.E.2
  • 18
    • 33646901265 scopus 로고    scopus 로고
    • daf-16 protects the nematode Caenorhabditis elegans during food deprivation
    • HENDERSON, S. T., M. BONAFE and T. E. JOHNSON, 2006 daf-16 protects the nematode Caenorhabditis elegans during food deprivation. J. Gerontol. A Biol. Sci. Med. Sci. 61: 444-460.
    • (2006) J. Gerontol. A Biol. Sci. Med. Sci , vol.61 , pp. 444-460
    • HENDERSON, S.T.1    BONAFE, M.2    JOHNSON, T.E.3
  • 19
    • 11144355021 scopus 로고    scopus 로고
    • HERTWECK, M., C. GOBEL and R. BAUMEISTER, 2004 C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6: 577-588.
    • HERTWECK, M., C. GOBEL and R. BAUMEISTER, 2004 C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6: 577-588.
  • 20
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • HONDA, Y., and S. HONDA, 1999 The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13: 1385-1393.
    • (1999) FASEB J , vol.13 , pp. 1385-1393
    • HONDA, Y.1    HONDA, S.2
  • 21
    • 0033609291 scopus 로고    scopus 로고
    • Signals from the reproductive system regulate the lifespan of C. elegans
    • HSIN, H., and C. KENYON, 1999 Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399: 362-366.
    • (1999) Nature , vol.399 , pp. 362-366
    • HSIN, H.1    KENYON, C.2
  • 22
    • 0141481091 scopus 로고    scopus 로고
    • FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
    • JACOBS, F. M., L. P. VAN DER HEIDE, P. J. WIJCHERS, J. P. BURBACH, M. F. HOEKMAN et al., 2003 FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J. Biol. Chem. 278: 35959-35967.
    • (2003) J. Biol. Chem , vol.278 , pp. 35959-35967
    • JACOBS, F.M.1    VAN DER HEIDE, L.P.2    WIJCHERS, P.J.3    BURBACH, J.P.4    HOEKMAN, M.F.5
  • 23
    • 13944269223 scopus 로고    scopus 로고
    • The plasticity of aging: Insights from long-lived mutants
    • KENYON, C., 2005 The plasticity of aging: insights from long-lived mutants. Cell 120: 449-460.
    • (2005) Cell , vol.120 , pp. 449-460
    • KENYON, C.1
  • 24
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • KENYON, C., J. CHANG, E. GENSCH, A. RUDNER and R. TABTIANG, 1993 A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
    • (1993) Nature , vol.366 , pp. 461-464
    • KENYON, C.1    CHANG, J.2    GENSCH, E.3    RUDNER, A.4    TABTIANG, R.5
  • 25
    • 0030813398 scopus 로고    scopus 로고
    • daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • KIMURA, K. D., H. A. TISSENBAUM, Y. LIU and G. RUVKUN, 1997 daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946.
    • (1997) Science , vol.277 , pp. 942-946
    • KIMURA, K.D.1    TISSENBAUM, H.A.2    LIU, Y.3    RUVKUN, G.4
  • 26
    • 0028930267 scopus 로고
    • Genes that regulate both development and longevity in Caenorhabditis elegans
    • LARSEN, P. L., P. S. ALBERT and D. L. RIDDLE, 1995 Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139: 1567-1583.
    • (1995) Genetics , vol.139 , pp. 1567-1583
    • LARSEN, P.L.1    ALBERT, P.S.2    RIDDLE, D.L.3
  • 27
    • 0035846601 scopus 로고    scopus 로고
    • Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    • LEE, R. Y., J. HENCH and G. RUVKUN, 2001 Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11: 1950-1957.
    • (2001) Curr. Biol , vol.11 , pp. 1950-1957
    • LEE, R.Y.1    HENCH, J.2    RUVKUN, G.3
  • 28
    • 0037466652 scopus 로고    scopus 로고
    • DAF-16 target genes that control C. elegans life-span and metabolism
    • LEE, S. S., S. KENNEDY, A. C. TOLONENAND G. RUVKUN, 2003 DAF-16 target genes that control C. elegans life-span and metabolism. Science 300: 644-647.
    • (2003) Science , vol.300 , pp. 644-647
    • LEE, S.S.1    KENNEDY, S.2    TOLONENAND, A.C.3    RUVKUN, G.4
  • 29
    • 0345447590 scopus 로고    scopus 로고
    • Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    • LIBINA, N., J. R. BERMAN and C. KENYON, 2003 Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115: 489-502.
    • (2003) Cell , vol.115 , pp. 489-502
    • LIBINA, N.1    BERMAN, J.R.2    KENYON, C.3
  • 30
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • LIN, K., H. HSIN, N. LIBINA and C. KENYON, 2001 Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28: 139-145.
    • (2001) Nat. Genet , vol.28 , pp. 139-145
    • LIN, K.1    HSIN, H.2    LIBINA, N.3    KENYON, C.4
  • 31
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • MCELWEE, J., K. BUBB and J. H. THOMAS, 2003 Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2: 111-121.
    • (2003) Aging Cell , vol.2 , pp. 111-121
    • MCELWEE, J.1    BUBB, K.2    THOMAS, J.H.3
  • 32
    • 3242683216 scopus 로고    scopus 로고
    • Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans
    • MCKAY, S. J., R. JOHNSEN, J. KHATTRA, J. ASANO, D. L. BAILLIE et al., 2003 Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans. Cold Spring Harbor Symp. Quant. Biol. 68: 159-169.
    • (2003) Cold Spring Harbor Symp. Quant. Biol , vol.68 , pp. 159-169
    • MCKAY, S.J.1    JOHNSEN, R.2    KHATTRA, J.3    ASANO, J.4    BAILLIE, D.L.5
  • 33
    • 0033595003 scopus 로고    scopus 로고
    • The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
    • MIHAYLOVA, V. T., C. Z. BORLAND, L. MANJARREZ, M. J. STERN and H. SUN, 1999 The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc. Natl. Acad. Sci. USA 96: 7427-7432.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7427-7432
    • MIHAYLOVA, V.T.1    BORLAND, C.Z.2    MANJARREZ, L.3    STERN, M.J.4    SUN, H.5
  • 34
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • MURPHY, C. T., S. A. MCCARROLL, C. I. BARGMANN, A. FRASER, R. S. KAMATH et al., 2003 Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424: 277-283.
    • (2003) Nature , vol.424 , pp. 277-283
    • MURPHY, C.T.1    MCCARROLL, S.A.2    BARGMANN, C.I.3    FRASER, A.4    KAMATH, R.S.5
  • 35
    • 0032238299 scopus 로고    scopus 로고
    • The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
    • OGG, S., and G. RUVKUN, 1998 The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell. 2: 887-893.
    • (1998) Mol. Cell , vol.2 , pp. 887-893
    • OGG, S.1    RUVKUN, G.2
  • 36
    • 31744438846 scopus 로고    scopus 로고
    • Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    • OH, S. W., A. MUKHOPADHYAY, B. L. DIXIT, T. RAHA, M. R. GREEN et al., 2006 Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat. Genet. 38: 251-257.
    • (2006) Nat. Genet , vol.38 , pp. 251-257
    • OH, S.W.1    MUKHOPADHYAY, A.2    DIXIT, B.L.3    RAHA, T.4    GREEN, M.R.5
  • 37
    • 0032529189 scopus 로고    scopus 로고
    • Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    • PARADIS, S., and G. RUVKUN, 1998 Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12: 2488-2498.
    • (1998) Genes Dev , vol.12 , pp. 2488-2498
    • PARADIS, S.1    RUVKUN, G.2
  • 38
    • 0033151613 scopus 로고    scopus 로고
    • A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
    • PARADIS, S., M. AILION, A. TOKER, J. H. THOMAS and G. RUVKUN, 1999 A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 13: 1438-1452.
    • (1999) Genes Dev , vol.13 , pp. 1438-1452
    • PARADIS, S.1    AILION, M.2    TOKER, A.3    THOMAS, J.H.4    RUVKUN, G.5
  • 39
    • 0033602383 scopus 로고    scopus 로고
    • Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
    • ROUAULT, J. P., P. E. KUWABARA, O. M. SINILNIKOVA, L. DURET, D. THIERRY-MIEG et al., 1999 Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Curr. Biol. 9: 329-332.
    • (1999) Curr. Biol , vol.9 , pp. 329-332
    • ROUAULT, J.P.1    KUWABARA, P.E.2    SINILNIKOVA, O.M.3    DURET, L.4    THIERRY-MIEG, D.5
  • 40
    • 40449142493 scopus 로고    scopus 로고
    • Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
    • in press
    • SELMAN, C., S. LINGARD, A. I. CHOUDHURY, R. L. BATTERHAM, M. CLARET et al., 2007 Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. (in press).
    • (2007) FASEB J
    • SELMAN, C.1    LINGARD, S.2    CHOUDHURY, A.I.3    BATTERHAM, R.L.4    CLARET, M.5
  • 41
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • TAGUCHI, A., L. M. WARTSCHOW and M. F. WHITE, 2007 Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317: 369-372.
    • (2007) Science , vol.317 , pp. 369-372
    • TAGUCHI, A.1    WARTSCHOW, L.M.2    WHITE, M.F.3
  • 42
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • TATAR, M., A. BARTKE and A. ANTEBI, 2003 The endocrine regulation of aging by insulin-like signals. Science 299: 1346-1351.
    • (2003) Science , vol.299 , pp. 1346-1351
    • TATAR, M.1    BARTKE, A.2    ANTEBI, A.3
  • 43
    • 0035941485 scopus 로고    scopus 로고
    • Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans
    • TIMMONS, L., D. L. COURT and A. FIRE, 2001 Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263: 103-112.
    • (2001) Gene , vol.263 , pp. 103-112
    • TIMMONS, L.1    COURT, D.L.2    FIRE, A.3
  • 44
    • 27744432642 scopus 로고    scopus 로고
    • FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling
    • VAN DER HEIDE, L. P., F. M. JACOBS, J. P. BURBACH, M. F. HOEKMAN and M. P. SMIDT, 2005 FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling. Biochem. J. 391: 623-629.
    • (2005) Biochem. J , vol.391 , pp. 623-629
    • VAN DER HEIDE, L.P.1    JACOBS, F.M.2    BURBACH, J.P.3    HOEKMAN, M.F.4    SMIDT, M.P.5
  • 45
    • 12144288373 scopus 로고    scopus 로고
    • Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    • VAN REMMEN, H., Y. IKENO, M. HAMILTON, M. PAHLAVANI, N. WOLF et al., 2003 Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. Genomics 16: 29-37.
    • (2003) Physiol. Genomics , vol.16 , pp. 29-37
    • VAN REMMEN, H.1    IKENO, Y.2    HAMILTON, M.3    PAHLAVANI, M.4    WOLF, N.5
  • 46
    • 33751431218 scopus 로고    scopus 로고
    • The trifecta of aging in Caenorhabditis elegans
    • WOLFF, S., and A. DILLIN, 2006 The trifecta of aging in Caenorhabditis elegans. Exp. Gerontol. 41: 894-903.
    • (2006) Exp. Gerontol , vol.41 , pp. 894-903
    • WOLFF, S.1    DILLIN, A.2
  • 47
    • 33644750381 scopus 로고    scopus 로고
    • SMK-1, an essential regulator of DAF-16-mediated longevity
    • WOLFF, S., H. MA, D. BURCH, G. A. MACIEL, T. HUNTER et al., 2006 SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124: 1039-1053.
    • (2006) Cell , vol.124 , pp. 1039-1053
    • WOLFF, S.1    MA, H.2    BURCH, D.3    MACIEL, G.A.4    HUNTER, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.