-
1
-
-
0037127026
-
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
-
ARANTES-OLIVEIRA, N., J. APFELD, A. DILLIN and C. KENYON, 2002 Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295: 502-505.
-
(2002)
Science
, vol.295
, pp. 502-505
-
-
ARANTES-OLIVEIRA, N.1
APFELD, J.2
DILLIN, A.3
KENYON, C.4
-
3
-
-
33644772542
-
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling
-
BERMAN, J. R., and C. KENYON, 2006 Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell 124: 1055-1068.
-
(2006)
Cell
, vol.124
, pp. 1055-1068
-
-
BERMAN, J.R.1
KENYON, C.2
-
4
-
-
0016063911
-
The genetics of Caenorhabditis elegans
-
BRENNER, S., 1974 The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
-
(1974)
Genetics
, vol.77
, pp. 71-94
-
-
BRENNER, S.1
-
5
-
-
33846436789
-
A steroid hormone that extends the lifespan of Caenorhabditis elegans
-
BROUE, F., P. LIERE, C. KENYON and E. E. BAULIEU, 2007 A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell 6: 87-94.
-
(2007)
Aging Cell
, vol.6
, pp. 87-94
-
-
BROUE, F.1
LIERE, P.2
KENYON, C.3
BAULIEU, E.E.4
-
6
-
-
34548614737
-
Loss of pregnancy-associated plasma protein A extends lifespan in mice
-
CONOVER, C. A., and L. K. BALE, 2007 Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell 6: 727-729.
-
(2007)
Aging Cell
, vol.6
, pp. 727-729
-
-
CONOVER, C.A.1
BALE, L.K.2
-
7
-
-
0037174629
-
Timing requirements for insulin/IGF-1 signaling in C. elegans
-
DILLIN, A., D. K. CRAWFORD and C. KENYON, 2002 Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830-834.
-
(2002)
Science
, vol.298
, pp. 830-834
-
-
DILLIN, A.1
CRAWFORD, D.K.2
KENYON, C.3
-
8
-
-
34547810054
-
Quantitative mass spectrometry identifies insulin signaling targets in C. elegans
-
DONG, M.-Q., J. D. VENABLE, N. AU, T. XU, S. K. PARK et al., 2007 Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science 317: 660-663.
-
(2007)
Science
, vol.317
, pp. 660-663
-
-
DONG, M.-Q.1
VENABLE, J.D.2
AU, N.3
XU, T.4
PARK, S.K.5
-
9
-
-
0028807085
-
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
-
DORMAN, J. B., B. ALBINDER, T. SHROYER and C. KENYON, 1995 The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141: 1399-1406.
-
(1995)
Genetics
, vol.141
, pp. 1399-1406
-
-
DORMAN, J.B.1
ALBINDER, B.2
SHROYER, T.3
KENYON, C.4
-
10
-
-
2442565649
-
Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans
-
FUJII, M., Y. MATSUMOTO, N. TANAKA, K. MIKI, T. SUZUKI et al., 2004 Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans. J. Biol. Chem. 279: 20277-20282.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 20277-20282
-
-
FUJII, M.1
MATSUMOTO, Y.2
TANAKA, N.3
MIKI, K.4
SUZUKI, T.5
-
11
-
-
0034661826
-
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
-
FURUYAMA, T., T. NAKAZAWA, I. NAKANO and N. MORI, 2000 Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349: 629-634.
-
(2000)
Biochem. J
, vol.349
, pp. 629-634
-
-
FURUYAMA, T.1
NAKAZAWA, T.2
NAKANO, I.3
MORI, N.4
-
12
-
-
0036021375
-
Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation
-
GARIGAN, D., A. L. HSU, A. G. FRASER, R. S. KAMATH, J. AHRINGER et al., 2002 Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161: 1101-1112.
-
(2002)
Genetics
, vol.161
, pp. 1101-1112
-
-
GARIGAN, D.1
HSU, A.L.2
FRASER, A.G.3
KAMATH, R.S.4
AHRINGER, J.5
-
13
-
-
0031685525
-
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction, and longevity in Caenorhabditis elegans
-
GEMS, D., A. J. SUTTON, M. L. SUNDERMEYER, P. S. ALBERT, K. V. KING et al., 1998 Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction, and longevity in Caenorhabditis elegans. Genetics 150: 129-155.
-
(1998)
Genetics
, vol.150
, pp. 129-155
-
-
GEMS, D.1
SUTTON, A.J.2
SUNDERMEYER, M.L.3
ALBERT, P.S.4
KING, K.V.5
-
14
-
-
0035656274
-
A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
-
GERISCH, B., C. WEITZEL, C. KOBER- EISERMANN, V. ROTTIERS and A. ANTEBI, 2001 A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev. Cell 1: 841-851.
-
(2001)
Dev. Cell
, vol.1
, pp. 841-851
-
-
GERISCH, B.1
WEITZEL, C.2
KOBER- EISERMANN, C.3
ROTTIERS, V.4
ANTEBI, A.5
-
15
-
-
34247563364
-
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
-
GERISCH, B., V. ROTTIERS, D. LI, D. L. MOTOLA, C. L. CUMMINS et al., 2007 A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 104: 5014-5019.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 5014-5019
-
-
GERISCH, B.1
ROTTIERS, V.2
LI, D.3
MOTOLA, D.L.4
CUMMINS, C.L.5
-
16
-
-
0032981396
-
Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene
-
GIL, E. B., E. MALONE LINK, L. X. LIU, C. D. JOHNSON and J. A. LEES, 1999 Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene. Proc. Natl. Acad. Sci. USA 96: 2925-2930.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2925-2930
-
-
GIL, E.B.1
MALONE LINK, E.2
LIU, L.X.3
JOHNSON, C.D.4
LEES, J.A.5
-
17
-
-
0035846604
-
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
HENDERSON, S. T., and T. E. JOHNSON, 2001 daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11: 1975-1980.
-
(2001)
Curr. Biol
, vol.11
, pp. 1975-1980
-
-
HENDERSON, S.T.1
JOHNSON, T.E.2
-
19
-
-
11144355021
-
-
HERTWECK, M., C. GOBEL and R. BAUMEISTER, 2004 C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6: 577-588.
-
HERTWECK, M., C. GOBEL and R. BAUMEISTER, 2004 C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6: 577-588.
-
-
-
-
20
-
-
0032782364
-
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
-
HONDA, Y., and S. HONDA, 1999 The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13: 1385-1393.
-
(1999)
FASEB J
, vol.13
, pp. 1385-1393
-
-
HONDA, Y.1
HONDA, S.2
-
21
-
-
0033609291
-
Signals from the reproductive system regulate the lifespan of C. elegans
-
HSIN, H., and C. KENYON, 1999 Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399: 362-366.
-
(1999)
Nature
, vol.399
, pp. 362-366
-
-
HSIN, H.1
KENYON, C.2
-
22
-
-
0141481091
-
FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
-
JACOBS, F. M., L. P. VAN DER HEIDE, P. J. WIJCHERS, J. P. BURBACH, M. F. HOEKMAN et al., 2003 FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J. Biol. Chem. 278: 35959-35967.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 35959-35967
-
-
JACOBS, F.M.1
VAN DER HEIDE, L.P.2
WIJCHERS, P.J.3
BURBACH, J.P.4
HOEKMAN, M.F.5
-
23
-
-
13944269223
-
The plasticity of aging: Insights from long-lived mutants
-
KENYON, C., 2005 The plasticity of aging: insights from long-lived mutants. Cell 120: 449-460.
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
KENYON, C.1
-
24
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
KENYON, C., J. CHANG, E. GENSCH, A. RUDNER and R. TABTIANG, 1993 A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
KENYON, C.1
CHANG, J.2
GENSCH, E.3
RUDNER, A.4
TABTIANG, R.5
-
25
-
-
0030813398
-
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
KIMURA, K. D., H. A. TISSENBAUM, Y. LIU and G. RUVKUN, 1997 daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946.
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
KIMURA, K.D.1
TISSENBAUM, H.A.2
LIU, Y.3
RUVKUN, G.4
-
26
-
-
0028930267
-
Genes that regulate both development and longevity in Caenorhabditis elegans
-
LARSEN, P. L., P. S. ALBERT and D. L. RIDDLE, 1995 Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139: 1567-1583.
-
(1995)
Genetics
, vol.139
, pp. 1567-1583
-
-
LARSEN, P.L.1
ALBERT, P.S.2
RIDDLE, D.L.3
-
27
-
-
0035846601
-
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
-
LEE, R. Y., J. HENCH and G. RUVKUN, 2001 Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11: 1950-1957.
-
(2001)
Curr. Biol
, vol.11
, pp. 1950-1957
-
-
LEE, R.Y.1
HENCH, J.2
RUVKUN, G.3
-
28
-
-
0037466652
-
DAF-16 target genes that control C. elegans life-span and metabolism
-
LEE, S. S., S. KENNEDY, A. C. TOLONENAND G. RUVKUN, 2003 DAF-16 target genes that control C. elegans life-span and metabolism. Science 300: 644-647.
-
(2003)
Science
, vol.300
, pp. 644-647
-
-
LEE, S.S.1
KENNEDY, S.2
TOLONENAND, A.C.3
RUVKUN, G.4
-
29
-
-
0345447590
-
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
-
LIBINA, N., J. R. BERMAN and C. KENYON, 2003 Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115: 489-502.
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
LIBINA, N.1
BERMAN, J.R.2
KENYON, C.3
-
30
-
-
0034967720
-
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
-
LIN, K., H. HSIN, N. LIBINA and C. KENYON, 2001 Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28: 139-145.
-
(2001)
Nat. Genet
, vol.28
, pp. 139-145
-
-
LIN, K.1
HSIN, H.2
LIBINA, N.3
KENYON, C.4
-
31
-
-
0042631524
-
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
-
MCELWEE, J., K. BUBB and J. H. THOMAS, 2003 Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2: 111-121.
-
(2003)
Aging Cell
, vol.2
, pp. 111-121
-
-
MCELWEE, J.1
BUBB, K.2
THOMAS, J.H.3
-
32
-
-
3242683216
-
Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans
-
MCKAY, S. J., R. JOHNSEN, J. KHATTRA, J. ASANO, D. L. BAILLIE et al., 2003 Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans. Cold Spring Harbor Symp. Quant. Biol. 68: 159-169.
-
(2003)
Cold Spring Harbor Symp. Quant. Biol
, vol.68
, pp. 159-169
-
-
MCKAY, S.J.1
JOHNSEN, R.2
KHATTRA, J.3
ASANO, J.4
BAILLIE, D.L.5
-
33
-
-
0033595003
-
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
-
MIHAYLOVA, V. T., C. Z. BORLAND, L. MANJARREZ, M. J. STERN and H. SUN, 1999 The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc. Natl. Acad. Sci. USA 96: 7427-7432.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7427-7432
-
-
MIHAYLOVA, V.T.1
BORLAND, C.Z.2
MANJARREZ, L.3
STERN, M.J.4
SUN, H.5
-
34
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
MURPHY, C. T., S. A. MCCARROLL, C. I. BARGMANN, A. FRASER, R. S. KAMATH et al., 2003 Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424: 277-283.
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
MURPHY, C.T.1
MCCARROLL, S.A.2
BARGMANN, C.I.3
FRASER, A.4
KAMATH, R.S.5
-
35
-
-
0032238299
-
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
-
OGG, S., and G. RUVKUN, 1998 The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell. 2: 887-893.
-
(1998)
Mol. Cell
, vol.2
, pp. 887-893
-
-
OGG, S.1
RUVKUN, G.2
-
36
-
-
31744438846
-
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
-
OH, S. W., A. MUKHOPADHYAY, B. L. DIXIT, T. RAHA, M. R. GREEN et al., 2006 Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat. Genet. 38: 251-257.
-
(2006)
Nat. Genet
, vol.38
, pp. 251-257
-
-
OH, S.W.1
MUKHOPADHYAY, A.2
DIXIT, B.L.3
RAHA, T.4
GREEN, M.R.5
-
37
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
-
PARADIS, S., and G. RUVKUN, 1998 Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12: 2488-2498.
-
(1998)
Genes Dev
, vol.12
, pp. 2488-2498
-
-
PARADIS, S.1
RUVKUN, G.2
-
38
-
-
0033151613
-
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
-
PARADIS, S., M. AILION, A. TOKER, J. H. THOMAS and G. RUVKUN, 1999 A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 13: 1438-1452.
-
(1999)
Genes Dev
, vol.13
, pp. 1438-1452
-
-
PARADIS, S.1
AILION, M.2
TOKER, A.3
THOMAS, J.H.4
RUVKUN, G.5
-
39
-
-
0033602383
-
Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
-
ROUAULT, J. P., P. E. KUWABARA, O. M. SINILNIKOVA, L. DURET, D. THIERRY-MIEG et al., 1999 Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Curr. Biol. 9: 329-332.
-
(1999)
Curr. Biol
, vol.9
, pp. 329-332
-
-
ROUAULT, J.P.1
KUWABARA, P.E.2
SINILNIKOVA, O.M.3
DURET, L.4
THIERRY-MIEG, D.5
-
40
-
-
40449142493
-
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
-
in press
-
SELMAN, C., S. LINGARD, A. I. CHOUDHURY, R. L. BATTERHAM, M. CLARET et al., 2007 Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. (in press).
-
(2007)
FASEB J
-
-
SELMAN, C.1
LINGARD, S.2
CHOUDHURY, A.I.3
BATTERHAM, R.L.4
CLARET, M.5
-
41
-
-
34547097247
-
Brain IRS2 signaling coordinates life span and nutrient homeostasis
-
TAGUCHI, A., L. M. WARTSCHOW and M. F. WHITE, 2007 Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317: 369-372.
-
(2007)
Science
, vol.317
, pp. 369-372
-
-
TAGUCHI, A.1
WARTSCHOW, L.M.2
WHITE, M.F.3
-
42
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
TATAR, M., A. BARTKE and A. ANTEBI, 2003 The endocrine regulation of aging by insulin-like signals. Science 299: 1346-1351.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
TATAR, M.1
BARTKE, A.2
ANTEBI, A.3
-
43
-
-
0035941485
-
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans
-
TIMMONS, L., D. L. COURT and A. FIRE, 2001 Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263: 103-112.
-
(2001)
Gene
, vol.263
, pp. 103-112
-
-
TIMMONS, L.1
COURT, D.L.2
FIRE, A.3
-
44
-
-
27744432642
-
FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling
-
VAN DER HEIDE, L. P., F. M. JACOBS, J. P. BURBACH, M. F. HOEKMAN and M. P. SMIDT, 2005 FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling. Biochem. J. 391: 623-629.
-
(2005)
Biochem. J
, vol.391
, pp. 623-629
-
-
VAN DER HEIDE, L.P.1
JACOBS, F.M.2
BURBACH, J.P.3
HOEKMAN, M.F.4
SMIDT, M.P.5
-
45
-
-
12144288373
-
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
-
VAN REMMEN, H., Y. IKENO, M. HAMILTON, M. PAHLAVANI, N. WOLF et al., 2003 Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. Genomics 16: 29-37.
-
(2003)
Physiol. Genomics
, vol.16
, pp. 29-37
-
-
VAN REMMEN, H.1
IKENO, Y.2
HAMILTON, M.3
PAHLAVANI, M.4
WOLF, N.5
-
46
-
-
33751431218
-
The trifecta of aging in Caenorhabditis elegans
-
WOLFF, S., and A. DILLIN, 2006 The trifecta of aging in Caenorhabditis elegans. Exp. Gerontol. 41: 894-903.
-
(2006)
Exp. Gerontol
, vol.41
, pp. 894-903
-
-
WOLFF, S.1
DILLIN, A.2
-
47
-
-
33644750381
-
SMK-1, an essential regulator of DAF-16-mediated longevity
-
WOLFF, S., H. MA, D. BURCH, G. A. MACIEL, T. HUNTER et al., 2006 SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124: 1039-1053.
-
(2006)
Cell
, vol.124
, pp. 1039-1053
-
-
WOLFF, S.1
MA, H.2
BURCH, D.3
MACIEL, G.A.4
HUNTER, T.5
|