Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by αvβ3 and β1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway

Journal of Biological Chemistry

Volumn 285, Issue 1, 2010, Pages 30-42

  Lee, Ding Yu ^a,b,c   Li, Yi Shuan J ^b   Chang, Shun Fu ^a   Zhou, Jing ^b   Ho, Hui Min ^a   Chiu, Jeng Jiann ^a,c   Chien, Shu ^b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE CELL GROWTH; BONE FORMATION; BONE TISSUE; CO-IMMUNOPRECIPITATION ASSAYS; CYCLINS; DOMINANT-NEGATIVE MUTANTS; FOCAL ADHESION KINASE; HUMAN OSTEOBLAST LIKES; INTEGRINS; INTERSTITIAL FLOW; LY294002; MG63 CELLS; MICROENVIRONMENTS; OSCILLATORY FLOWS; OSCILLATORY SHEAR; OSTEOBLAST-LIKE CELLS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE; SIGNALING CASCADES; SMALL INTERFERENCE RNA; SUSTAINED ACTIVATION; SYNERGISTIC INTERACTION; UNDERLYING MECHANISM;

ADHESION; BONE; CELL PROLIFERATION; GROWTH KINETICS; SHEAR STRESS;

GLYCOPROTEINS;

2 MORPHOLINO 8 PHENYLCHROMONE; BETA1 INTEGRIN; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLOOXYGENASE 2; EARLY GROWTH RESPONSE FACTOR 1; FOCAL ADHESION KINASE; MAMMALIAN TARGET OF RAPAMYCIN; P70S6 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE SUBUNIT P85; PHOSPHOTRANSFERASE; PROTEIN C FOS; PROTEIN KINASE B; PROTEIN SHC; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MG63; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; OSCILLATORY SHEAR STRESS; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SHEAR STRESS; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD29; CELL CYCLE PROTEINS; CELL LINE; CELL PROLIFERATION; CYCLOOXYGENASE 2; EARLY GROWTH RESPONSE PROTEIN 1; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION; HUMANS; INTEGRIN ALPHAVBETA3; MULTIPROTEIN COMPLEXES; OSTEOBLASTS; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-FOS; RHEOLOGY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 73649139225     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.010512     Document Type: Article

References (57)

1. Chow, J. W., Wilson, A. J., Chambers, T. J., and Fox, S. W. (1998) J. Bone Miner. Res. 13, 1760-1767
2. Forwood, M. R., Owan, I., Takano, Y., and Turner, C. H. (1996) Am. J. Physiol. Endocrinol. Metab. 270, E419-E423
3. Hillam, R. A., and Skerry, T. M. (1995) J. Bone Miner. Res. 10, 683-689
4. Sikavitsas, V. I., Temenoff, J. S., and Mikos, A. G. (2001) Biomaterials 22, 2581-2593
5. Rubin, J., Rubin, C., and Jacobs, C. R. (2006) Gene 367, 1-16
6. Turner, C. H., and Pavalko, F. M. (1998) J. Orthop. Sci. 3, 346-355
7. Jiang, G. L., White, C. R., Stevens, H. Y., and Frangos, J. A. (2002) Am. J. Physiol. Endocrinol. Metab. 283, E383-E389
8. Lee, D. Y., Yeh, C. R., Chang, S. F., Lee, P. L., Chien, S., Cheng, C. K., and Chiu, J. J. (2008) J. Bone Miner. Res. 23, 1140-1149
9. Young, S. R., Gerard-O'Riley, R., Kim, J. B., and Pavalko, F. M. (2009) J. Bone Miner. Res. 24, 411-424
10. Kapur, S., Baylink, D. J., and Lau, K. H. (2003) Bone 32, 241-251
11. Kapur, S., Chen, S. T., Baylink, D. J., and Lau, K. H. (2004) Bone 35, 525-534
12. Pavalko, F. M., Chen, N. X., Turner, C. H., Burr, D. B., Atkinson, S., Hsieh, Y. F., Qiu, J., and Duncan, R. L. (1998) Am. J. Physiol. Cell Physiol. 275, C1591-C1601
13. Ogata, T. (1997) J. Cell Physiol. 170, 27-34
14. McMahon, A. P., Champion, J. E., McMahon, J. A., and Sukhatme, V. P. (1990) Development 108, 281-287
15. Turner, C. H., Tu, Y., and Onyia, J. E. (1996) Ann. Biomed. Eng. 24, S74
16. Forwood, M. R. (1996) J. Bone Miner. Res. 11, 1688-1693
17. Morinobu, M., Ishijima, M., Rittling, S. R., Tsuji, K., Yamamoto, H., Nifuji, A., Denhardt, D. T., and Noda, M. (2003) J. Bone Miner. Res. 18, 1706-1715
18. McAllister, T. N., and Frangos, J. A. (1999) J. Bone Miner. Res. 14, 930-936
19. Klein-Nulend, J., Semeins, C. M., Ajubi, N. E., Nijweide, P. J., and Burger, E. H. (1995) Biochem. Biophys. Res. Commun. 217, 640-648
20. Bakker, A. D., Soejima, K., Klein-Nulend, J., and Burger, E. H. (2001) J. Biomech. 34, 671-677
21. Thomas, G., and Hall, M. N. (1997) Curr. Opin. Cell Biol. 9, 782-787
22. Singha, U. K., Jiang, Y., Yu, S., Luo, M., Lu, Y., Zhang, J., and Xiao, G. (2008) J. Cell Biochem. 103, 434-446
23. Giancotti, F. G., and Ruoslahti, E. (1999) Science 285, 1028-1032
24. Shyy, J. Y., and Chien, S. (2002) Circ. Res. 91, 769-775
25. Clover, J., and Gowen, M. (1994) Bone 15, 585-591
26. Li, S., Kim, M., Hu, Y. L., Jalali, S., Schlaepfer, D. D., Hunter, T., Chien, S., and Shyy, J. Y. (1997) J. Biol. Chem. 272, 30455-30462
27. Chen, K. D., Li, Y. S., Kim, M., Li, S., Yuan, S., Chien, S., and Shyy, J. Y. (1999) J. Biol. Chem. 274, 18393-18400
28. Hillsley, M. V., and Frangos, J. A. (1997) Calcif. Tissue Int. 60, 48-53
29. Wu, C. C., Li, Y. S., Haga, J. H., Wang, N., Lian, I. Y., Su, F. C., Usami, S., and Chien, S. (2006) J. Cell Biochem. 98, 632-641
30. Weinbaum, S., Cowin, S. C., and Zeng, Y. (1994) J. Biomech. 27, 339-360
31. Miltenburger, H. G., Sachse, G., and Schliermann, M. (1987) Dev. Biol. Stand. 66, 91-99
32. Wary, K. K., Mainiero, F., Isakoff, S. J., Marcantonio, E. E., and Giancotti, F. G. (1996) Cell 87, 733-743
33. Jalali, S., del Pozo, M. A., Chen, K., Miao, H., Li, Y., Schwartz, M. A., Shyy, J. Y., and Chien, S. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 1042-1046
34. Miyamoto, S., Akiyama, S. K., and Yamada, K. M. (1995) Science 267, 883-885
35. Chang, S. F., Chang, C. A., Lee, D. Y., Lee, P. L., Yeh, Y. M., Yeh, C. R., Cheng, C. K., Chien, S., and Chiu, J. J. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 3927-3932
36. Ren, S. Y., Bolton, E., Mohi, M. G., Morrione, A., Neel, B. G., and Skorski, T. (2005) Mol. Cell Biol. 25, 8001-8008
37. Akagi, T., Murata, K., Shishido, T., and Hanafusa, H. (2002) Mol. Cell Biol. 22, 7015-7023
38. Chattopadhyay, N., Yano, S., Tfelt-Hansen, J., Rooney, P., Kanuparthi, D., Bandyopadhyay, S., Ren, X., Terwilliger, E., and Brown, E. M. (2004) Endocrinology 145, 3451-3462
39. Harris, T. E., and Lawrence, J. C., Jr. (2003) Sci. STKE 2003, re15
40. Kozawa, O., Matsuno, H., and Uematsu, T. (2001) J. Cell Biochem. 31, 430-436
41. Shoba, L. N., and Lee, J. C. (2003) J. Cell Biochem. 88, 1247-1255
42. Wang, Y., McNamara, L. M., Schaffler, M. B., and Weinbaum, S. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 15941-15946
43. Plotkin, L. I., Mathov, I., Aguirre, J. I., Parfitt, A. M., Manolagas, S. C., and Bellido, T. (2005) Am. J. Physiol. Cell Physiol. 289, C633-C643
44. Globus, R. K., Doty, S. B., Lull, J. C., Holmuhamedov, E., Humphries, M. J., and Damsky, C. H. (1998) J. Cell Sci. 111, 1385-1393
45. Scarlett, A., Parsons, M. P., Hanson, P. L., Sidhu, K. K., Milligan, T. P., and Burrin, J. M. (2008) J. Endocrinol. 196, 509-517
46. Schlaepfer, D. D., and Hunter, T. (1998) Trends Cell Biol. 8, 151-157
47. Schlaepfer, D. D., Hauck, C. R., and Sieg, D. J. (1999) Prog. Biophys. Mol. Biol. 71, 435-478
48. Hellyer, N. J., Cheng, K., and Koland, J. G. (1998) Biochem. J. 333, 757-763
49. McGlade, C. J., Ellis, C., Reedijk, M., Anderson, D., Mbamalu, G., Reith, A. D., Panayotou, G., End, P., Bernstein, A., and Kazlauskas, A. (1992) Mol. Cell Biol. 12, 991-997
50. Wymann, M. P., and Pirola, L. (1998) Biochim. Biophys. Acta 1436, 127-150
51. Gayer, C. P., Chaturvedi, L. S., Wang, S., Craig, D. H., Flanigan, T., and Basson, M. D. (2009) J. Biol. Chem. 284, 2001-2011
52. Sherr, C. J. (1993) Cell 73, 1059-1065
53. Hunter, T., and Pines, J. (1994) Cell 79, 573-582
54. Sherr, C. J., and Roberts, J. M. (1995) Genes Dev. 9, 1149-1163
55. Toyoshima, H., and Hunter, T. (1994) Cell 78, 67-74
56. Glantschnig, H., Varga, F., and Klaushofer, K. (1996) Endocrinology 137, 4536-4541
57. Kousteni, S., Han, L., Chen, J. R., Almeida, M., Plotkin, L. I., Bellido, T., and Manolagas, S. C. (2003) J. Clin. Invest. 111, 1651-1664