-
1
-
-
34447098797
-
Multistep pathogenesis of autoimmune disease
-
Goodnow C.C. Multistep pathogenesis of autoimmune disease. Cell 2007, 130:25-35.
-
(2007)
Cell
, vol.130
, pp. 25-35
-
-
Goodnow, C.C.1
-
3
-
-
2442567829
-
Back to central tolerance
-
Mathis D., Benoist C. Back to central tolerance. Immunity 2004, 20:509-516.
-
(2004)
Immunity
, vol.20
, pp. 509-516
-
-
Mathis, D.1
Benoist, C.2
-
4
-
-
33645071052
-
Central tolerance: good but imperfect
-
Gallegos A.M., Bevan M.J. Central tolerance: good but imperfect. Immunol. Rev. 2006, 209:290-296.
-
(2006)
Immunol. Rev.
, vol.209
, pp. 290-296
-
-
Gallegos, A.M.1
Bevan, M.J.2
-
5
-
-
72949104779
-
Antigen presentation in the thymus for positive selection and central tolerance induction
-
Klein L., et al. Antigen presentation in the thymus for positive selection and central tolerance induction. Nat. Rev. Immunol. 2009, 9:833-844.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 833-844
-
-
Klein, L.1
-
6
-
-
43949105866
-
Regulatory T cells and immune tolerance
-
Sakaguchi S., et al. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
-
(2008)
Cell
, vol.133
, pp. 775-787
-
-
Sakaguchi, S.1
-
7
-
-
0035171545
-
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
-
Derbinski J., et al. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2001, 2:1032-1039.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 1032-1039
-
-
Derbinski, J.1
-
8
-
-
0942288397
-
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
-
Gotter J., et al. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J. Exp. Med. 2004, 199:155-166.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 155-166
-
-
Gotter, J.1
-
9
-
-
0028817585
-
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-[kappa]B/Rel family
-
Weih F., et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-[kappa]B/Rel family. Cell 1995, 80:331-340.
-
(1995)
Cell
, vol.80
, pp. 331-340
-
-
Weih, F.1
-
10
-
-
0028952482
-
Expression of relB is required for the development of thymic medulla and dendritic cells
-
Burkly L., et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 1995, 373:531-536.
-
(1995)
Nature
, vol.373
, pp. 531-536
-
-
Burkly, L.1
-
11
-
-
10744226628
-
NF-{kappa}B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner
-
Kajiura F., et al. NF-{kappa}B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J. Immunol. 2004, 172:2067-2075.
-
(2004)
J. Immunol.
, vol.172
, pp. 2067-2075
-
-
Kajiura, F.1
-
12
-
-
33646055527
-
Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance
-
Kinoshita D., et al. Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance. J. Immunol. 2006, 176:3995-4002.
-
(2006)
J. Immunol.
, vol.176
, pp. 3995-4002
-
-
Kinoshita, D.1
-
13
-
-
16444377660
-
Dependence of self-tolerance on TRAF6-directed development of thymic stroma
-
Akiyama T., et al. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 2005, 308:248-251.
-
(2005)
Science
, vol.308
, pp. 248-251
-
-
Akiyama, T.1
-
14
-
-
40049092383
-
Lymphotoxin receptor is required for the migration and selection of autoreactive T cells in thymic medulla
-
Zhu M., et al. Lymphotoxin receptor is required for the migration and selection of autoreactive T cells in thymic medulla. J. Immunol. 2007, 179:8069-8075.
-
(2007)
J. Immunol.
, vol.179
, pp. 8069-8075
-
-
Zhu, M.1
-
15
-
-
33845996957
-
NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells
-
Zhang B., et al. NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells. J. Biol. Chem. 2006, 281:38617-38624.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 38617-38624
-
-
Zhang, B.1
-
16
-
-
0041884736
-
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LT{beta}R
-
Boehm T., et al. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LT{beta}R. J. Exp. Med. 2003, 198:757-769.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 757-769
-
-
Boehm, T.1
-
17
-
-
34548679394
-
A Role for the I[kappa]B family member Bcl-3 in the control of central immunologic tolerance
-
Zhang X., et al. A Role for the I[kappa]B family member Bcl-3 in the control of central immunologic tolerance. Immunity 2007, 27:438-452.
-
(2007)
Immunity
, vol.27
, pp. 438-452
-
-
Zhang, X.1
-
18
-
-
0033490887
-
Disorganization of thymic medulla precedes evolution towards diabetes in female NOD mice
-
Atlan-Gepner C., et al. Disorganization of thymic medulla precedes evolution towards diabetes in female NOD mice. Autoimmunity 1999, 31:249-260.
-
(1999)
Autoimmunity
, vol.31
, pp. 249-260
-
-
Atlan-Gepner, C.1
-
19
-
-
0028987010
-
Thymic microenvironmental abnormalities in MRL/MP-lpr/lpr, BXSB/MpJYaa and C3H HeJ-gld/gld mice
-
Takeoka Y., et al. Thymic microenvironmental abnormalities in MRL/MP-lpr/lpr, BXSB/MpJYaa and C3H HeJ-gld/gld mice. J. Autoimmun. 1995, 8:145-161.
-
(1995)
J. Autoimmun.
, vol.8
, pp. 145-161
-
-
Takeoka, Y.1
-
20
-
-
0346599403
-
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
-
Aaltonen J., et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 1997, 17:399-403.
-
(1997)
Nat. Genet.
, vol.17
, pp. 399-403
-
-
Aaltonen, J.1
-
21
-
-
16944367194
-
Positional cloning of the APECED gene
-
Nagamine K., et al. Positional cloning of the APECED gene. Nat. Genet. 1997, 17:393-398.
-
(1997)
Nat. Genet.
, vol.17
, pp. 393-398
-
-
Nagamine, K.1
-
22
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson M.S., et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002, 298:1395-1401.
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
-
23
-
-
0037383758
-
Aire regulates negative selection of organ-specific T cells
-
Liston A., et al. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 2003, 4:350-354.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 350-354
-
-
Liston, A.1
-
24
-
-
23844558032
-
The cellular mechanism of Aire control of T cell tolerance
-
Anderson M.S., et al. The cellular mechanism of Aire control of T cell tolerance. Immunity 2005, 23:227-239.
-
(2005)
Immunity
, vol.23
, pp. 227-239
-
-
Anderson, M.S.1
-
25
-
-
13544262691
-
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
-
Kuroda N., et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 2005, 174:1862-1870.
-
(2005)
J. Immunol.
, vol.174
, pp. 1862-1870
-
-
Kuroda, N.1
-
26
-
-
33646413687
-
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice
-
Niki S., et al. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J. Clin. Invest. 2006, 116:1292-1301.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1292-1301
-
-
Niki, S.1
-
27
-
-
35748941369
-
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
-
Gray D., et al. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J. Exp. Med. 2007, 204:2521-2528.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2521-2528
-
-
Gray, D.1
-
28
-
-
58149316251
-
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
-
Yano M., et al. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J. Exp. Med. 2008, 205:2827-2838.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2827-2838
-
-
Yano, M.1
-
29
-
-
33751513054
-
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
-
DeVoss J., et al. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J. Exp. Med. 2006, 203:2727-2735.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 2727-2735
-
-
DeVoss, J.1
-
30
-
-
0033006011
-
Development and maturation of secondary lymphoid tissues
-
Fu Y.X., Chaplin D.D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 1999, 17:399-433.
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 399-433
-
-
Fu, Y.X.1
Chaplin, D.D.2
-
31
-
-
42649122256
-
Development of secondary lymphoid organs
-
Randall T.D., et al. Development of secondary lymphoid organs. Annu. Rev. Immunol. 2008, 26:627-650.
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 627-650
-
-
Randall, T.D.1
-
32
-
-
0242624626
-
Lymphotoxin pathway directs thymic Aire expression
-
Chin R.K., et al. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 2003, 4:1121-1127.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1121-1127
-
-
Chin, R.K.1
-
33
-
-
33745290201
-
Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen
-
Chin R.K., et al. Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J. Immunol. 2006, 177:290-297.
-
(2006)
J. Immunol.
, vol.177
, pp. 290-297
-
-
Chin, R.K.1
-
34
-
-
38449096249
-
Lymphotoxin pathway and Aire Influences on thymic medullary epithelial cells are unconnected
-
Venanzi E.S., et al. Lymphotoxin pathway and Aire Influences on thymic medullary epithelial cells are unconnected. J. Immunol. 2007, 179:5693-5700.
-
(2007)
J. Immunol.
, vol.179
, pp. 5693-5700
-
-
Venanzi, E.S.1
-
35
-
-
70350127935
-
Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition
-
Zhou P., et al. Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:17134-17139.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 17134-17139
-
-
Zhou, P.1
-
36
-
-
7244227645
-
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
-
Gallegos A.M., Bevan M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 2004, 200:1039-1049.
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1039-1049
-
-
Gallegos, A.M.1
Bevan, M.J.2
-
37
-
-
56549085984
-
The thymus medulla slowly yields its secrets
-
Tykocinski L.-O., et al. The thymus medulla slowly yields its secrets. Ann. N. Y. Acad. Sci. 2008, 1143:105-122.
-
(2008)
Ann. N. Y. Acad. Sci.
, vol.1143
, pp. 105-122
-
-
Tykocinski, L.-O.1
-
38
-
-
22344449972
-
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
-
Derbinski J., et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 2005, 202:33-45.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 33-45
-
-
Derbinski, J.1
-
39
-
-
37549071821
-
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells
-
Gabler J., et al. Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells. Eur. J. Immunol. 2007, 37:3363-3372.
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 3363-3372
-
-
Gabler, J.1
-
40
-
-
33646165128
-
A central role for central tolerance
-
Kyewski B., Klein L. A central role for central tolerance. Annu. Rev. Immunol. 2006, 24:571-606.
-
(2006)
Annu. Rev. Immunol.
, vol.24
, pp. 571-606
-
-
Kyewski, B.1
Klein, L.2
-
41
-
-
0141567432
-
Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway
-
Weih F., Caamano J. Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway. Immunol. Rev. 2003, 195:91-105.
-
(2003)
Immunol. Rev.
, vol.195
, pp. 91-105
-
-
Weih, F.1
Caamano, J.2
-
42
-
-
45949094459
-
The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells
-
Seach N., et al. The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells. J. Immunol. 2008, 180:5384-5392.
-
(2008)
J. Immunol.
, vol.180
, pp. 5384-5392
-
-
Seach, N.1
-
43
-
-
51349101423
-
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity
-
Irla M., et al. Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 2008, 29:451-463.
-
(2008)
Immunity
, vol.29
, pp. 451-463
-
-
Irla, M.1
-
44
-
-
51349092893
-
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
-
Hikosaka Y., et al. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 2008, 29:438-450.
-
(2008)
Immunity
, vol.29
, pp. 438-450
-
-
Hikosaka, Y.1
-
45
-
-
51349111243
-
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
-
Akiyama T., et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 2008, 29:423-437.
-
(2008)
Immunity
, vol.29
, pp. 423-437
-
-
Akiyama, T.1
-
46
-
-
51349110485
-
Coordinating development of medullary thymic epithelial cells
-
Zhu M., Fu Y.-X. Coordinating development of medullary thymic epithelial cells. Immunity 2008, 29:386-388.
-
(2008)
Immunity
, vol.29
, pp. 386-388
-
-
Zhu, M.1
Fu, Y.-X.2
-
47
-
-
33750585066
-
NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway
-
Zhu M., et al. NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J. Clin. Invest. 2006, 116:2964-2971.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2964-2971
-
-
Zhu, M.1
-
48
-
-
70350131707
-
CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens
-
Nitta T., et al. CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc. Natl Acad. Sci. U. S. A. 2009, 106:17129-17133.
-
(2009)
Proc. Natl Acad. Sci. U. S. A.
, vol.106
, pp. 17129-17133
-
-
Nitta, T.1
-
49
-
-
33644845679
-
Journey through the thymus: stromal guides for T-cell development and selection
-
Takahama Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 2006, 6:127-135.
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 127-135
-
-
Takahama, Y.1
-
50
-
-
34247882592
-
Zoned out: functional mapping of stromal signaling microenvironments in the thymus
-
Petrie H.T., Zuniga-Pflucker J.C. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol. 2007, 25:649-679.
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 649-679
-
-
Petrie, H.T.1
Zuniga-Pflucker, J.C.2
-
51
-
-
34250336454
-
RANK signals from CD4+3- inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
-
Rossi S.W., et al. RANK signals from CD4+3- inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J. Exp. Med. 2007, 204:1267-1272.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1267-1272
-
-
Rossi, S.W.1
-
52
-
-
47949100152
-
Lt{beta}r signaling does not regulate aire-dependent transcripts in medullary thymic epithelial cells
-
Martins V.C., et al. Lt{beta}r signaling does not regulate aire-dependent transcripts in medullary thymic epithelial cells. J. Immunol. 2008, 181:400-407.
-
(2008)
J. Immunol.
, vol.181
, pp. 400-407
-
-
Martins, V.C.1
-
53
-
-
0031760741
-
Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis
-
Mackay F., et al. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology 1998, 115:1464-1475.
-
(1998)
Gastroenterology
, vol.115
, pp. 1464-1475
-
-
Mackay, F.1
-
54
-
-
0037869086
-
A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis
-
Fava R.A., et al. A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis. J. Immunol. 2003, 171:115-126.
-
(2003)
J. Immunol.
, vol.171
, pp. 115-126
-
-
Fava, R.A.1
-
55
-
-
58949096547
-
Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury
-
Ruddell R.G., et al. Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. Hepatology 2009, 49:227-239.
-
(2009)
Hepatology
, vol.49
, pp. 227-239
-
-
Ruddell, R.G.1
-
56
-
-
33745298519
-
Nuclear factor-[kappa]B in cancer development and progression
-
Karin M. Nuclear factor-[kappa]B in cancer development and progression. Nature 2006, 441:431-436.
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
57
-
-
0037099523
-
Lymphotoxin-{beta} receptor immune interaction promotes tumor growth by inducing angiogenesis
-
Hehlgans T., et al. Lymphotoxin-{beta} receptor immune interaction promotes tumor growth by inducing angiogenesis. Cancer Res. 2002, 62:4034-4040.
-
(2002)
Cancer Res.
, vol.62
, pp. 4034-4040
-
-
Hehlgans, T.1
-
58
-
-
70349568358
-
A lymphotoxin-driven pathway to hepatocellular carcinoma
-
Haybaeck J., et al. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 2009, 16:295-308.
-
(2009)
Cancer Cell
, vol.16
, pp. 295-308
-
-
Haybaeck, J.1
|