A1 Adenosine Receptors Accumulate in Neurodegenerative Structures in Alzheimer Disease and Mediate Both Amyloid Precursor Protein Processing and Tau Phosphorylation and Translocation

Brain Pathology

Volumn 13, Issue 4, 2003, Pages 440-451

  Angulo, Ester ^b   Casadó, Vicent ^b   Mallol, Josefa ^b   Canela, Enric I ^b   Viñals, Francesc ^b   Ferrer, Isidre ^b   Lluis, Carmen ^b   Franco, Rafael ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETAA4 PROTEIN; AMYLOID PRECURSOR PROTEIN; METABOTROPIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN P21; TAU PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLIA CELL; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEUROFIBRILLARY TANGLE; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENILE PLAQUE; STRIATE CORTEX;

EID: 0242416171     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2003.tb00475.x     Document Type: Article

References (44)

1. Braak H, Braak E (1999) Temporal sequence of Alzheimer's disease-related pathology. In Cerebral cortex vol 14; Neurodegenerative and age-related changes in structure and function of cerebral cortex. A Peters and JH Morrison (eds.), Kluwer Academic/Plenum Publishers, New York, Boston, Dordrecht, London, Moscow. pp. 475-512.
2. Buée L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33:95-130.
3. Buxbaum JD, Oishi M, Chen HI, Pinkas-Kramarski R, Jaffe EA, Gandy SE, Greengard P (1992) Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc Natl Acad Sci U S A 89:10075-10078.
4. Chin JY, Knowles RB, Schneider A, Drewes G, Mandelkow EM, Hyman BT (2000) Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: a fluorescence resonance energy transfer study. J Neuropathol Exp Neurol 59:966-971.
5. Ciruela F, Casado V, Mallol J, Canela EI, Lluis C, Franco R (1995) Immunological identification of A1 adenosine receptors in brain cortex. J Neurosci Res 42:818-828.
6. Deckert J, Abel F, Künig G, Hartman J, Senitz D, Maier H, Ransmayr G, Riederer P (1998). Loss of human hippocampal adenosine A1 receptors in dementia: evidence for lack of specificity. Neurosci Letters 244:1-4.
7. De Strooper B, Annaert W (2000) Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci 113:1857-1870.
8. De Rooij J, Bos JL (1997) Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14:623-625.
9. Drewer G, Lichtenberg-Kraag B, Doering F, Mandelkow EM, Biernat J, Goris J, Doree M, Mandelkow E (1992) Mitogen-activated protein (MAP) kinase transfoms tau protein into an Alzheimer-like state. EMBO J 6:2131-2138.
10. Dunwiddie TV, Masino SA (2001) The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci 24:31-55.
11. Ferrer I, Blanco R, Carmona M, Puig B (2001a) Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. J Neural Transm 108:1397-1415.
12. Ferrer I, Blanco R, Carmona M, Ribera R, Goutan E, Puig B, Rey MJ, Cardozo A, Viñals F, Ribalta T (2001 b) Phosphorylated MAP kinase (ERK, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degenerationn. Brain Pathol 11:144-158.
13. Ferre S, Karcz-Kubicha M, Hope BT, Popoli P, Burgueno J, Gutierrez MA, Casado V, Fuxe K, Goldberg SR, Lluis C, Franco R, Ciruela F (2002) Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function. Proc Natl Acad Sci U S A 99:11940-11945.
14. García-Jiménez A, Cowburn RF, Ohm TG, Lasn H, Winblad B, Bogdanovic N, Fastbom J (2002) Loss of stimulatory effect of guanosine triphosphate on [35S]GTPgammaS binding correlates with Alzheimer disease neurofibrillary pathology intentorhinal cortex and CA1 hippocampal subfield. J Neurosci Res 67:388-398
15. Gauthier S, Panisset M, Nalbantoglu J, Poirier J (1997) Alzheimer's disease: current knowledge, management and research. Can Med Association 157:1047-1052.
16. Ginés S, Hillion J, Torvinen M, Le Crom S, Casado V, Canela EI, Rondin S, Lew JY, Watson S, Zoli M, Agnati LF, Verniera P, Lluis C, Ferre S, Fuxe K, Franco R (2000) Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. Proc Natl Acad Sci U S A 97:8606-8611.
17. Goedert M, Cohen ES, Jakes R, Cohen P (1992) p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. FEBS Lett 312:95-99.
18. Gomez-Santos C, Ferrer I, Reiriz J, Vinals F, Barrachina M, Ambrosio S (2002) MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. Brain Res 935:32-39.
19. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
20. Isacson O, Seo H, Lin L, Albeck D, Granholm AC (2002) Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends Neurosci 25:79-84.
21. Jacobsen JS, Spruyt MA, Brown AM, Sahasrabudhe SR, Blume AJ, Vitek MP, Muenkel HA, Sonnenberg-Reines J (1994) The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment. J Biol Chem 269:8376-8382.
22. Jenkins SM, Zinnerman M, Garner C, Johnson GVW (2000) Modulation of tau phosphorylation and intracellular localization by cellular stress. Biochem J 345:263-270.
23. Jolly-Tornetta C, Wolf B (2000) Protein kinase C regulation of intracellular and cell surface amyloid precursor protein (APP) cleavage in CHO695 cells. Biochemistry 39:15282-15290.
24. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A (2001) alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 276:13541-13546.
25. Klinger M, Freissmuth M, Nanoff C (2002) Adenosine receptors: G protein-mediated signalling and the role of accessory proteins. Cell Signalling 14:99-108.
26. Knowles RB, Chin J, Ruff CT, Hyman BT (1999) Demonstration by fluorescence resonance energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: Implications for MAP kinase activation in Alzheimer disease. J Neuropathol Exp Neurol 58:1090-1098.
27. Laemmli, UK (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
28. Ledesma MD, Correas I, Avila J, Diaz-Nido J (1992) Implication of cdc2 and MAP2 kinases in the phosphorylation of tau proteins in Alzheimer's disease. FEBS Lett 308:218-224.
29. Lee RK, Wurtman RJ, Cox AJ, Nitsch RM (1995) Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc Natl Acad Sci U S A 92:8083-8087.
30. Lovestone S, Reynolds CH (1997) The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes. Neuroscience 78:309-324.
31. Mandelkow EM, Schweers O, Drewes G, Biernat J, Gustke N, Trinczek B, Mandelkow E (1996) Structure, microtubule interactions, and phosphorylation of tau protein. Ann N Y Acad Sci 777:96-106.
32. Mudher A, Lovestone S (2002) Alzheimer's disease -do tauists and baptists finally shake hands? Trends Neurosci 25:22-26.
33. Nitsch RM, Deng A, Wurtman RJ, Growdon JH (1997) Metabotropic glutamate receptor subtype mGluRlalpha stimulates the secretion of the amyloid beta-protein precursor ectodomain. J Neurochem 69:704-712.
34. Perry G, Roder H, Nunomura A, Takeda A, Friedlich AL, Zhu X, Raina AL, Holbrook N, Siedlak SL, Harris PLR, Smith MA (1999) Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal tau phosphorylation. NeuroReport 10:2411-2415.
35. Sarrio S, Casado V, Escriche M, Ciruela F, Mallol J, Canela EI, Lluis O, Franco R (2000) The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane. Mol Cell Biol 20:5164-5174.
36. Schindler M, Harris CA, Hayes B, Papottu M, Humphrey PPA (2001) Immunohistochemical localization of adenosine A1 receptors in human brain regions. Neurosci Letters 297:211-215.
37. Schulte G, Fredholm BB (2000) Human adenosine A1, A2A, A2b and A3 receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2. Mol Pharmacol 58:477-482.
38. Sinha S, Lieberburg I (1999) Cellular mechanisms of beta-amyloid production and secretion. Proc Natl Acad Sci U S A 96:11049-11053.
39. Stephenson DT, Clemens JA (1998) Metabotropic glutamate receptor activation in vivo induces intraneuronal amyloid immunoreactivity in guinea pig hippocampus. Neurochem Int 33:83-93.
40. Tanzi RE, Bertram L (2001) New frontiers in Alzheimer's disease genetics. Neuron 25:181-184.
41. Veeranna GJ, Amin ND, Ahn NG, Jaffe J, Winters CA, Grant P, Pant HC (1998) Mitogen-activated protein kinases (Erk1, 2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. J Neurosci 18:4008-4021.
42. Walter J, Kaether C, Steiner H, Haass C (2001) The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Curr Opin Neurobiol 11:585-590.
43. Zhu X, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA (2000) Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 59:880-888.
44. Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, Smith MA (2001) Activation and re-distribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem 76:435-441.