메뉴 건너뛰기




Volumn 24, Issue 9, 2010, Pages 1782-1793

Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CHORIONIC GONADOTROPIN; CYCLIC AMP; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; FORSKOLIN; LUTEINIZING HORMONE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN S6; RAPAMYCIN; S6 KINASE; SMALL INTERFERING RNA; TUBERIN;

EID: 77956097751     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0044     Document Type: Article
Times cited : (43)

References (55)
  • 1
    • 0036296059 scopus 로고    scopus 로고
    • The ovarian androgen-producing cells: A 2001 perspective
    • Magoffin DA 2002 The ovarian androgen-producing cells: a 2001 perspective. Rev Endocr Metab Disord 3:47-53
    • (2002) Rev Endocr Metab Disord , vol.3 , pp. 47-53
    • Magoffin, D.A.1
  • 3
    • 0026675659 scopus 로고
    • Intracellular signaling in the gonads
    • Leung PC, Steele GL 1992 Intracellular signaling in the gonads. Endocr Rev 13:476-498
    • (1992) Endocr Rev , vol.13 , pp. 476-498
    • Leung, P.C.1    Steele, G.L.2
  • 4
    • 3242877826 scopus 로고    scopus 로고
    • Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress
    • DOI 10.1093/humrep/deh299
    • Duleba AJ, Foyouzi N, Karaca M, Pehlivan T, Kwintkiewicz J, Behrman HR 2004 Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress. Hum Reprod 19:1519-1524 (Pubitemid 38997174)
    • (2004) Human Reproduction , vol.19 , Issue.7 , pp. 1519-1524
    • Duleba, A.J.1    Foyouzi, N.2    Karaca, M.3    Pehlivan, T.4    Kwintkiewicz, J.5    Behrman, H.R.6
  • 5
    • 24644449033 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis
    • DOI 10.1093/molehr/gah168
    • Spaczynski RZ, Tilly JL, Mansour A, Duleba AJ 2005 Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. Mol Hum Reprod 11:319-324 (Pubitemid 41417864)
    • (2005) Molecular Human Reproduction , vol.11 , Issue.5 , pp. 319-324
    • Spaczynski, R.Z.1    Tilly, J.L.2    Mansour, A.3    Duleba, A.J.4
  • 6
    • 0035051203 scopus 로고    scopus 로고
    • Luteinizing hormone receptor, steroidogenesis acute regulatory protein, and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries
    • DOI 10.1210/jc.86.3.1318
    • Jakimiuk AJ, Weitsman SR, Navab A, Magoffin DA 2001 Luteinizing hormone receptor, steroidogenesis acute regulatory protein, and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries. J Clin Endocrinol Metab 86:1318-1323 (Pubitemid 32323023)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.3 , pp. 1318-1323
    • Jakimiuk, A.J.1    Weitsman, S.R.2    Navab, A.3    Magoffin, D.A.4
  • 7
    • 33745185834 scopus 로고    scopus 로고
    • Ovarian enzyme activities in women with polycystic ovary syndrome
    • Magoffin DA 2006 Ovarian enzyme activities in women with polycystic ovary syndrome. Fertil Steril 86(Suppl 1):S9-S11
    • (2006) Fertil Steril , vol.86 , Issue.SUPPL. 1
    • Magoffin, D.A.1
  • 8
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks S 1995 Polycystic ovary syndrome. N Engl J Med 333:853-861
    • (1995) N Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 9
    • 0041402647 scopus 로고    scopus 로고
    • Androgen excess is the key element in polycystic ovary syndrome
    • DOI 10.1016/S0015-0282(03)00735-0
    • Azziz R 2003 Androgen excess is the key element in polycystic ovary syndrome. Fertil Steril 80:252-254 (Pubitemid 36959774)
    • (2003) Fertility and Sterility , vol.80 , Issue.2 , pp. 252-254
    • Azziz, R.1
  • 10
    • 0035154289 scopus 로고    scopus 로고
    • New signaling pathways for hormones and cyclic adenosine 3′,5′- Monophosphate action in endocrine cells
    • Richards JS 2001 New signaling pathways for hormones and cyclic adenosine 3′,5′- monophosphate action in endocrine cells. Mol Endocrinol 15:209-218
    • (2001) Mol Endocrinol , vol.15 , pp. 209-218
    • Richards, J.S.1
  • 11
    • 0036288282 scopus 로고    scopus 로고
    • Multiple signal transduction pathways regulate ovarian steroidogenesis
    • DOI 10.1023/A:1012748718150
    • Wood JR, Strauss 3rd JF 2002 Multiple signal transduction pathways regulate ovarian steroidogenesis. Rev Endocr Metab Disord 3:33-46 (Pubitemid 34693403)
    • (2002) Reviews in Endocrine and Metabolic Disorders , vol.3 , Issue.1 , pp. 33-46
    • Wood, J.R.1    Strauss III, J.F.2
  • 12
    • 33744810660 scopus 로고    scopus 로고
    • FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase a
    • DOI 10.1016/j.cellsig.2006.02.011, PII S0898656806000465
    • Hunzicker-Dunn M, Maizels ET 2006 FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A. Cell Signal 18:1351-1359 (Pubitemid 43832089)
    • (2006) Cellular Signalling , vol.18 , Issue.9 , pp. 1351-1359
    • Hunzicker-Dunn, M.1    Maizels, E.T.2
  • 13
    • 2442485795 scopus 로고    scopus 로고
    • Follicle-stimulating Hormone Activation of Hypoxia-inducible Factor-1 by the Phosphatidylinositol 3-Kinase/AKT/Ras Homolog Enriched in Brain (Rheb)/Mammalian Target of Rapamycin (mTOR) Pathway Is Necessary for Induction of Select Protein Markers of Follicular Differentiation
    • DOI 10.1074/jbc.M401235200
    • Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS, Hunzicker-Dunn M 2004 Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. J Biol Chem 279:19431-19440 (Pubitemid 38623376)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.19 , pp. 19431-19440
    • Alam, H.1    Maizels, E.T.2    Park, Y.3    Ghaey, S.4    Feiger, Z.J.5    Chandel, N.S.6    Hunzicker-Dunn, M.7
  • 14
    • 33748756497 scopus 로고    scopus 로고
    • AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2α
    • DOI 10.1074/jbc.M605371200
    • Arvisais EW, Romanelli A, Hou X, Davis JS 2006 AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2α. J Biol Chem 281:26904-26913 (Pubitemid 44401719)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.37 , pp. 26904-26913
    • Arvisais, E.W.1    Romanelli, A.2    Hou, X.3    Davis, J.S.4
  • 15
    • 34547124065 scopus 로고    scopus 로고
    • Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of rapamycin signaling through an extracellular signal-regulated kinase-dependent pathway in rat granulosa cells
    • Kayampilly PP, Menon KMJ 2007 Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of rapamycin signaling through an extracellular signal-regulated kinase-dependent pathway in rat granulosa cells. Endocrinology 148:3950-3957
    • (2007) Endocrinology , vol.148 , pp. 3950-3957
    • Kayampilly, P.P.1    Menon, K.M.J.2
  • 16
    • 0034463096 scopus 로고    scopus 로고
    • Follicle-stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-induced kinase (Sgk): Evidence for a kinase-independent signaling by FSH in granulosa cells
    • DOI 10.1210/me.14.8.1283
    • Gonzalez-Robayna IJ, Falender AE, Ochsner S, Firestone GL, Richards JS 2000 Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/AKT) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells. Mol Endocrinol 14:1283-1300 (Pubitemid 32260488)
    • (2000) Molecular Endocrinology , vol.14 , Issue.8 , pp. 1283-1300
    • Gonzalez-Robayna, I.J.1    Falender, A.E.2    Ochsner, S.3    Firestone, G.L.4    Richards, J.S.5
  • 17
    • 0042922520 scopus 로고    scopus 로고
    • Protein kinase B is obligatory for follicle-stimulating hormone-induced granulosa cell differentiation
    • DOI 10.1210/en.2003-0293
    • Zeleznik AJ, Saxena D, Little-Ihrig L 2003 Protein kinase B is obligatory for follicle-stimulating hormone-induced granulosa cell differentiation. Endocrinology 144:3985-3994 (Pubitemid 37088754)
    • (2003) Endocrinology , vol.144 , Issue.9 , pp. 3985-3994
    • Zeleznik, A.J.1    Saxena, D.2    Little-Ihrig, L.3
  • 18
    • 33751533169 scopus 로고    scopus 로고
    • A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells
    • DOI 10.1210/me.2006-0241
    • Andric N, Ascoli M 2006 A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells. Mol Endocrinol 20:3308-3320 (Pubitemid 44833573)
    • (2006) Molecular Endocrinology , vol.20 , Issue.12 , pp. 3308-3320
    • Andric, N.1    Ascoli, M.2
  • 19
    • 22144448594 scopus 로고    scopus 로고
    • Luteinizing hormone-induced extracellular-signal regulated kinase activation differently modulates progesterone and androstenedione production in bovine theca cells
    • DOI 10.1210/en.2005-0093
    • Tajima K, Yoshii K, Fukuda S, Orisaka M, Miyamoto K, Amsterdam A, Kotsuji F 2005 Luteinizing hormone-induced extracellular-signal regulated kinase activation differently modulates progesterone and androstenedione production in bovine theca cells. Endocrinology 146:2903-2910 (Pubitemid 41002797)
    • (2005) Endocrinology , vol.146 , Issue.7 , pp. 2903-2910
    • Tajima, K.1    Yoshii, K.2    Fukuda, S.3    Orisaka, M.4    Miyamoto, K.5    Amsterdam, A.6    Kotsuji, F.7
  • 21
    • 0032230235 scopus 로고    scopus 로고
    • Hormone-induced proliferation and differentiation of granulosa cells: A coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1
    • Robker RL, Richards JS 1998 Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1. Mol Endocrinol 12: 924-940
    • (1998) Mol Endocrinol , vol.12 , pp. 924-940
    • Robker, R.L.1    Richards, J.S.2
  • 22
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM 2007 Defining the role of mTOR in cancer. Cancer Cell 12:9-22
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 23
  • 24
    • 12344262762 scopus 로고    scopus 로고
    • MTOR, translational control and human disease
    • DOI 10.1016/j.semcdb.2004.11.005, PII S1084952104001089, Protein Synthesis in Health and Disease
    • Tee AR, Blenis J 2005 mTOR, translational control and human disease. Semin Cell Dev Biol 16:29-37 (Pubitemid 40126874)
    • (2005) Seminars in Cell and Developmental Biology , vol.16 , Issue.1 , pp. 29-37
    • Tee, A.R.1    Blenis, J.2
  • 25
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma XM, Blenis J 2009 Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10:307-318
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 26
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • DOI 10.1101/gad.995802
    • Fingar DC, Salama S, Tsou C, Harlow E, Blenis J 2002 Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 16:1472-1487 (Pubitemid 34686329)
    • (2002) Genes and Development , vol.16 , Issue.12 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 27
    • 33745150462 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation: From protein synthesis to cell size
    • DOI 10.1016/j.tibs.2006.04.003, PII S0968000406001137
    • Ruvinsky I, Meyuhas O 2006 Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci 31:342-348 (Pubitemid 43903237)
    • (2006) Trends in Biochemical Sciences , vol.31 , Issue.6 , pp. 342-348
    • Ruvinsky, I.1    Meyuhas, O.2
  • 28
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N 2004 Upstream and downstream of mTOR. Genes Dev 18:1926-1945
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 31
    • 0038540963 scopus 로고    scopus 로고
    • United at last: The tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/AKT pathway to mammalian target of rapamycin (mTOR) signalling
    • Manning BD, Cantley LC 2003 United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/AKT pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans 31:573-578
    • (2003) Biochem Soc Trans , vol.31 , pp. 573-578
    • Manning, B.D.1    Cantley, L.C.2
  • 32
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • DOI 10.1038/ng1494
    • Inoki K, Corradetti MN, Guan KL 2005 Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37:19-24 (Pubitemid 40070934)
    • (2005) Nature Genetics , vol.37 , Issue.1 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.-L.3
  • 34
    • 0031032824 scopus 로고    scopus 로고
    • Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells
    • DOI 10.1074/jbc.272.4.2509
    • Withers DJ, Seufferlein T, Mann D, Garcia B, Jones N, Rozengurt E 1997 Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells. J Biol Chem 272:2509-25014 (Pubitemid 27058543)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.4 , pp. 2509-2514
    • Withers, D.J.1    Seufferlein, T.2    Mann, D.3    Garcia, B.4    Jones, N.5    Rozengurt, E.6
  • 35
    • 33747880070 scopus 로고    scopus 로고
    • Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins
    • DOI 10.1158/0008-5472.CAN-05-4472
    • Xu Y, Chen SY, Ross KN, Balk SP 2006 Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins. Cancer Res 66:7783-7792 (Pubitemid 44289239)
    • (2006) Cancer Research , vol.66 , Issue.15 , pp. 7783-7792
    • Xu, Y.1    Chen, S.-Y.2    Ross, K.N.3    Balk, S.P.4
  • 36
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • DOI 10.1038/sj.onc.1207542
    • Fingar DC, Blenis J 2004 Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151-3171 (Pubitemid 38638827)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 37
    • 0036712905 scopus 로고    scopus 로고
    • Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
    • DOI 10.1038/ncb847
    • Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D, Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D 2002 Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 4:699-704 (Pubitemid 34993706)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 699-704
    • Gao, X.1    Zhang, Y.2    Arrazola, P.3    Hino, O.4    Kobayashi, T.5    Yeung, R.S.6    Ru, B.7    Pan, D.8
  • 39
    • 0036501277 scopus 로고    scopus 로고
    • A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
    • Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N, Onda H 2002 A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11:525-534
    • (2002) Hum Mol Genet , vol.11 , pp. 525-534
    • Kwiatkowski, D.J.1    Zhang, H.2    Bandura, J.L.3    Heiberger, K.M.4    Glogauer, M.5    El-Hashemite, N.6    Onda, H.7
  • 40
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J 2002 Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA 99:13571-13576
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 41
    • 15244355263 scopus 로고    scopus 로고
    • Valproate-induced alterations in human theca cell gene expression: Clues to the association between valproate use and metabolic side effects
    • Wood JR, Nelson-Degrave VL, Jansen E, McAllister JM, Mosselman S, Strauss 3rd JF 2005 Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects. Physiol Genomics 20:233-243
    • (2005) Physiol Genomics , vol.20 , pp. 233-243
    • Wood, J.R.1    Nelson-Degrave, V.L.2    Jansen, E.3    McAllister, J.M.4    Mosselman, S.5    Strauss III, J.F.6
  • 42
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by AKT and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL 2002 TSC2 is phosphorylated and inhibited by AKT and suppresses mTOR signalling. Nat Cell Biol 4:648-657
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 43
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
    • DOI 10.1016/S1097-2765(02)00568-3
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC 2002 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/AKT pathway. Mol Cell 10:151-162 (Pubitemid 34876569)
    • (2002) Molecular Cell , vol.10 , Issue.1 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 44
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • DOI 10.1038/ncb840
    • Potter CJ, Pedraza LG, Xu T 2002 AKT regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 4:658-665 (Pubitemid 34993701)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 45
    • 0345732640 scopus 로고    scopus 로고
    • MTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E
    • DOI 10.1128/MCB.24.1.200-216.2004
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J 2004 mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24:200-216 (Pubitemid 38010048)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.1 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 46
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • DOI 10.1101/gad.995802
    • Fingar DC, Salama S, Tsou C, Harlow E, Blenis J 2002 Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 16:1472-1487 (Pubitemid 34686329)
    • (2002) Genes and Development , vol.16 , Issue.12 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 47
    • 24044442298 scopus 로고    scopus 로고
    • Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
    • Tee AR, Blenis J, Proud CG 2005 Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett 579:4763-4768
    • (2005) FEBS Lett , vol.579 , pp. 4763-4768
    • Tee, A.R.1    Blenis, J.2    Proud, C.G.3
  • 48
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN 2000 TOR, a central controller of cell growth. Cell. 103:253-262
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 49
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN 2006 TOR signaling in growth and metabolism. Cell 124:471-484
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 50
    • 33745150462 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation: From protein synthesis to cell size
    • DOI 10.1016/j.tibs.2006.04.003, PII S0968000406001137
    • Ruvinsky I, Meyuhas O 2006 Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci 31:342-348 (Pubitemid 43903237)
    • (2006) Trends in Biochemical Sciences , vol.31 , Issue.6 , pp. 342-348
    • Ruvinsky, I.1    Meyuhas, O.2
  • 51
    • 0027415831 scopus 로고
    • Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum
    • Bandi HR, Ferrari S, Krieg J, Meyer HE, Thomas G 1993 Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum. J Biol Chem 268:4530-4533 (Pubitemid 23073004)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.6 , pp. 4530-4533
    • Bandi, H.R.1    Ferrari, S.2    Krieg, J.3    Meyer, H.E.4    Thomas, G.5
  • 52
    • 0028788935 scopus 로고
    • The 70 kDa S6 kinase: Regulation of a kinase with multiple roles in mitogenic signaling
    • Chou MM, Blenis J 1995 The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signaling. Curr Opin Cell Biol 7:806-814
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 806-814
    • Chou, M.M.1    Blenis, J.2
  • 53
    • 0036399363 scopus 로고    scopus 로고
    • The S6 kinase signaling pathway in the control of development and growth
    • Thomas G 2002 The S6 kinase signaling pathway in the control of development and growth. Biol Res 35:305-313 (Pubitemid 35189803)
    • (2002) Biological Research , vol.35 , Issue.2 , pp. 305-313
    • Thomas, G.1
  • 54
    • 68049129979 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells
    • Palaniappan M, Menon KMJ 2009 Regulation of sterol regulatory element binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells. Biol Reprod 81:284-292
    • (2009) Biol Reprod , vol.81 , pp. 284-292
    • Palaniappan, M.1    Menon, K.M.J.2
  • 55
    • 0037562079 scopus 로고    scopus 로고
    • Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: Relative contribution of scavenger receptor class B (type I) and adenosine 5′-triphosphate-binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis
    • DOI 10.1210/en.2002-221110
    • Wu Q, Sucheta S, Azhar S, Menon KMJ 2003 Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5′-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis. Endocrinology 144:2437-2445 (Pubitemid 36629895)
    • (2003) Endocrinology , vol.144 , Issue.6 , pp. 2437-2445
    • Wu, Q.1    Sucheta, S.2    Azhar, S.3    Menon, K.M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.