Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells

Journal of Biological Chemistry

Volumn 272, Issue 4, 1997, Pages 2509-2514

  Withers, Dominic J ^a   Seufferlein, Thomas ^a   Mann, David ^a   Garcia, Bibian ^a   Jones, Nicholas ^a   Rozengurt, Enrique ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BOMBESIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; INSULIN; PROTEIN KINASE P70; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA SYNTHESIS; DOSE TIME EFFECT RELATION; DRUG POTENTIATION; GROWTH REGULATION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

3T3 CELLS; ANIMALS; BOMBESIN; CELL CYCLE PROTEINS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; IMMUNOSUPPRESSIVE AGENTS; INSULIN; MICE; MICROTUBULE-ASSOCIATED PROTEINS; ONCOGENE PROTEINS; PHOSPHORYLATION; POLYENES; PROTEIN-SERINE-THREONINE KINASES; RIBOSOMAL PROTEIN S6 KINASES; SIROLIMUS; THYMIDINE; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0031032824     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.4.2509     Document Type: Article

References (35)

1. Chou, M. M., and Blenis, J. (1995) Curr. Opin. Cell Biol. 7, 806-814
2. Ferrari, S., and Thomas, G. (1994) Crit. Rev. Biochem. Mol. Biol. 29, 385-413
3. de Groot, R. P., Ballou, L. M., and Sassone Corsi, P. (1994) Cell 79, 81-91
4. Chung, J., Kuo, C. J., Crabtree, G. R., and Blenis, J. (1992) Cell 69, 1227-1236
5. Price, D. J., Grove, J. R., Calvo, V., Avruch, J., and Bierer, B. E. (1992) Science 257, 973-977
6. Ferrari, S., Pearson, R. B., Siegmann, M., Kozma, S. C., and Thomas, G. (1993) J. Biol. Chem. 268, 16091-16094
7. Calvo, V., Crews, C. M., Vik, T. A., and Bierer, B. E. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 7571-7575
8. Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J., and Crabtree, G. R. (1992) Nature 358, 70-73
9. Francavilla, A., Carr, B. I., Starzl, T. E., Azzarone, A., Carrieri, G., and Zeng, Q. H. (1992) Hepatology 15, 871-877
10. Marx, S. O., Jayaraman, T., Go, L. O., and Marks, A. R. (1995) Circ. Res. 76, 412-417
11. Terada, N., Takase, K., Papst, P., Nairn, A. C., and Gelfand, E. W. (1995) J. Immunol. 155, 3418-3426
12. Terada, N., Franklin, R. A., Lucas, J. J., Blenis, J., and Gelfand, E. W. (1993) J. Biol. Chem. 268, 12062-12068
13. Frost, V., Morley, S. J., Mercep, L., Meyer, T., Fabbro, D., and Ferrari, S. (1995) J. Biol. Chem. 270, 26698-26706
14. Calvo, V., Wood, M., Gjertson, C., Vik, T., and Bierer, B. E. (1994) Eur. J. Immunol. 24, 2664-2671
15. Lane, H. A., Fernandez, A., Lamb, N. J., and Thomas, G. (1993) Nature 363, 170-172
16. Rozengurt, E. (1986) Science 234, 161-166
17. Rozengurt, E., and Sinnett Smith, J. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 2936-2940
18. Rozengurt, E. (1992) Curr. Opin. Cell Biol. 4, 161-165
19. Reinhard, C., Thomas, G., and Kozma, S. C. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 4052-4056
20. Pearson, A. B., Dennis, P. B., Han, J. W., Wiliiamson, N. A., Kozma, S. C., Wettenhall, R. E., and Thomas, G. (1995) EMBO J. 14, 5279-5287
21. Yeo, E.-J., and Exton, J. H. (1995) J. Biol. Chem. 270, 3980-3988
22. Sinnett-Smith, J., Zachary, I., Valverde, A. M., and Rozengurt, E. (1993) J. Biol. Chem. 268, 14261-14268
23. Sturgill, T. W., and Wu, J. (1991) Biochim. Biophys. Acta 1092, 350-357
24. Seufferlein, T., Withers, D. J., and Rozengurt, E. (1996) J. Biol. Chem. 271, 21471-21477
25. Sherr, C. J. (1993) Cell 73, 1059-1065
26. Nourse, J., Firpo, E., Flanagan, W. M., Coats, S., Polyak, K., Lee, M. H., Massague, J., Crabtree, G. R., and Roberts, J. M. (1994) Nature 372, 570-573
27. Kato, J. Y., Matsuoka, M., Polyak, K., Massague, J., and Sherr, C. J. (1994) Cell 79, 487-496
28. Rozengurt, E., Erusalimsky, J., Mehmet, H., Morris, C., Nanberg, E., and Sinnett Smith, J. (1988) Cold Spring Harbor Symp. Quant. Biol. 53, 945-954
29. Fardee, A. B. (1989) Science 246, 603-608
30. Millar, J. B. A., and Rozengurt, E. (1990) J. Biol. Chem. 265, 19973-19979
31. Withers, D. J., Bloom, S. R., and Rozengurt, E. (1995) J. Biol. Chem. 270, 21411-21419
32. Gil, J., Higgins, T., and Rozengurt, E. (1991) J. Cell Biol. 113, 943-950
33. Valius, M., and Kazlauskas, A. (1993) Cell 73, 321-334
34. Charlesworth, A., and Rozengurt, E. (1994) J. Biol. Chem. 269, 32528-32535
35. Nakayama, K., Ishida, N., Michiko, S., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D. Y., and Nakayama, K. (1996) Cell 85, 707-720