Synthesis and properties of macrolones characterized by two ether bonds in the linker

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6578-6588

  Jakopović, Ivana Palej ^a   Kragol, Goran ^a   Forrest, Andrew K ^a   Frydrych, Catherine S V ^a   Timac, Vlado ^a   Kapić, Samra ^a   Kugor, Maja Matanović ^a   Ilija, Marina ^a   Paljetak, Hana Ipić ^b   Jelić, Dubravko ^a   Holmes, David J ^c   Hickey, Deirdre M B ^a   Verbanac, Donatella ^b   Erakovićhaber, Vesna ^a   Alihodić, Sulejman ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c GLAXOSMITHKLINE   (United States)

Author keywords

4 Ether bond; Antibacterial activity; Macrolide; Macrolone; Quinolone

Indexed keywords

4O {3 [3 (6 CARBOXY 3,3 DIMETHYL 6 OXO 1H,6H 2 OXA 3A AZA PHENALEN 8 YL)PROPOXY]PROPYL} 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 4O {3 [3 (6 CARBOXY 3,3 DIMETHYL 7 OXO 2,3 DIHYDRO 7H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 9 YL)PROPOXY]PROPYL} 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 4O {3 [3 (6 CARBOXY 7 OXO 2,3 DIHYDRO 7H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 9 YL)PROPOXY]PROPYL} 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 4O {3 [4 (6 CARBOXY 3,3 DIMETHYL 7 OXO 2,3 DIHYDRO 7H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 9 YL)BUTOXY]PROPYL} 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; ANTIINFECTIVE AGENT; AZITHROMYCIN; CATION; DIAZONIUM COMPOUND; ERYTHROMYCIN; ETHER DERIVATIVE; MACROLIDE; TELITHROMYCIN; UNCLASSIFIED DRUG;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HAEMOPHILUS INFLUENZAE; HECK REACTION; HUMAN; HUMAN CELL; MICHAEL ADDITION; NONHUMAN; SONOGASHIRA REACTION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION;

AZITHROMYCIN; CROSS-LINKING REAGENTS; ETHERS; HUMANS; MACROLIDES; MODELS, CHEMICAL; MOLECULAR STRUCTURE;

EUKARYOTA;

EID: 77955982555     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.007     Document Type: Article

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