4″-O-(ω-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6559-6568

  Fajdetic A ^a   Ipic Paljetak H ^a   Lazarevski, G ^a   Hutinec, A ^a   Alihodic S ^a   Erek, M ^b   Timac, V ^a   Andreotti, D ^c   Unjic V ^a   Berge, J M ^a   Mutak, S ^b   Dumic M ^d   Lociuro, S ^c   Holmes, D J ^e   Maric N ^b   Erakovic Haber V ^a   Spaventi, R ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b PLIVA Research Institute Ltd   (Croatia)

^c GSK   (Italy)

^d PLIVA CROATIA LTD   (Croatia)

^e GLAXOSMITHKLINE   (United States)

Author keywords

Antibacterial activity; Macrolide; Quinolone; Resistance

Indexed keywords

4'' O [3 [[2 [(3 CARBOXY 1 CYCLOPROPYL 1,4 DIHYDRO 4 OXOQUINOLIN 6 YL)AMINO]ETHYL]AMINO]PROPANOYL]AZITHROMYCIN; 4'' O [3 [[2 [(3 CARBOXY 7 CHLORO 1 CYCLOPROPYL 1,4 DIHYDRO 4 OXOQUINOLIN 6 YL)AMINO]ETHYL]AMINO]PROPANOYL] 6 O METHYL 8A AZA 8A HOMOERYTHROMYCIN A; 4'' O [3 [[2 [(3 CARBOXY 7 CHLORO 1 CYCLOPROPYL 1,4 DIHYDRO 4 OXOQUINOLIN 6 YL)AMINO]ETHYL]AMINO]PROPANOYL] 6 O METHYLERYTHROMYCIN A; 4'' O [3 [[2 [(3 CARBOXY 7 CHLORO 1 CYCLOPROPYL 1,4 DIHYDRO 4 OXOQUINOLIN 6 YL)AMINO]ETHYL]METHYLAMINO]PROPANOYL]AZITHROMYCIN; AZITHROMYCIN; CLARITHROMYCIN DERIVATIVE; ERYTHROMYCIN; NITROGEN; QUINOLONE DERIVATIVE; TELITHROMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; MACROLIDE; PROPIONIC ACID DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; HAEMOPHILUS INFLUENZAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; BACTERIAL INFECTION; CHEMISTRY; HUMAN; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; HUMANS; MACROLIDES; MICROBIAL SENSITIVITY TESTS; PROPIONIC ACIDS;

EID: 77955980254     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.049     Document Type: Article

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