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Presented at 39th Intersci. Conf. Antimicrob. Agents Chemother.
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Bonnefoy A., Denis A., Bretin F., Fromentin C., Agouridas C. In vivo antibacterial activity of two ketolides HMR 3562 and HMR 3787 highly active against respiratory pathogens. Abstr. No. F-2156 1999.
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(1999)
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Bonnefoy, A.1
Denis, A.2
Bretin, F.3
Fromentin, C.4
Agouridas, C.5
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125
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85184363096
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In vitro antibacterial activity of CP-654,743, a new C2-fluoro ketolide, against macrolide-resistant pneumococci and Haemophilus influenzae
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Presented at 40th Intersci. Conf. Antimicrob. Agents Chemother
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Girard D., Mathieu H.W., Finegan S.M., Cimochowski C.R., Kaneko T., McMillen W. In vitro antibacterial activity of CP-654,743, a new C2-fluoro ketolide, against macrolide-resistant pneumococci and Haemophilus influenzae. Abstr. No. F-1816. 2000.
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Girard, D.1
Mathieu, H.W.2
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Cimochowski, C.R.4
Kaneko, T.5
McMillen, W.6
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126
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0033229837
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Synthesis and antibacterial activity of HMR 3647, a new ketolide highly potent against erythromycin-resistant and susceptible pathogens
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Denis A., Agouridas C., Auger J.-M., Benedetti Y., Bonnefoy A., Bretin F., Chantot J.-F., Dussarat A., Fromentin C., D'Ambrieres S.G., Lachaud S., Laurin P., Martret O.L., Loyau V., Tessot N., Pejac J.-M., Perron S. Synthesis and antibacterial activity of HMR 3647, a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. Bioorg. Med. Chem. Lett. 1999, 9:3075-3080.
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Denis, A.1
Agouridas, C.2
Auger, J.-M.3
Benedetti, Y.4
Bonnefoy, A.5
Bretin, F.6
Chantot, J.-F.7
Dussarat, A.8
Fromentin, C.9
D'Ambrieres, S.G.10
Lachaud, S.11
Laurin, P.12
Martret, O.L.13
Loyau, V.14
Tessot, N.15
Pejac, J.-M.16
Perron, S.17
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127
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In vitro activities of two ketolides, HMR 3647 and HMR 3004, against gram-positive bacteria
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Malathum K., Coque T.M., Singh K.V., Murray B.E. In vitro activities of two ketolides, HMR 3647 and HMR 3004, against gram-positive bacteria. Antimicrob. Agents Chemother. 1999, 43:930-936.
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Malathum, K.1
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Singh, K.V.3
Murray, B.E.4
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128
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85184385222
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Antipneumococcal activity (MIC) of HMR 3647 (RU 66647), a new ketolide, compared to 16 other agents
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Presented at 37th Intersci. Conf. Antimicrob. Agents Chemother
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Pankuch G.A., Jacobs M.R., Applebaum P.C. Antipneumococcal activity (MIC) of HMR 3647 (RU 66647), a new ketolide, compared to 16 other agents. Abstr. No. F-108 1997.
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Pankuch, G.A.1
Jacobs, M.R.2
Applebaum, P.C.3
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129
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85184382128
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Activity of telithromycin (HMR 3647), a new ketolide antimicrobial, against human mycoplasma
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Presented at 5th ICMAS-KO
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Bebear C.M., Renaudin H., Bryskier A., Bebear C. Activity of telithromycin (HMR 3647), a new ketolide antimicrobial, against human mycoplasma. Poster No. 02.35. 2000.
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Bebear, C.M.1
Renaudin, H.2
Bryskier, A.3
Bebear, C.4
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130
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In vitro activity of a new ketolide antibiotic, HMR 3647, against Chlamydia pneumoniae
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Roblin P.M., Hammerschlag M.R. In vitro activity of a new ketolide antibiotic, HMR 3647, against Chlamydia pneumoniae. Antimicrob. Agents Chemother. 1998, 42:1515-1516.
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Roblin, P.M.1
Hammerschlag, M.R.2
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131
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B resistance induction by the ketolide telithromycin (HMR 3647): Role of the 3-keto group
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B resistance induction by the ketolide telithromycin (HMR 3647): Role of the 3-keto group. Poster No. 02.10. 2000.
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Poster No. 02.10.
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Mauvaris, P.1
Bonnefoy, A.2
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132
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85184373330
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The C 11,12-carbamate side chain of the ketolide antimicrobial telithromycin (HMR 3647) enhances binding to both MLS-sensitive and-resistant ribosome
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Douthwaite S., Mauvaris P., Haastrup Hansen L. The C 11,12-carbamate side chain of the ketolide antimicrobial telithromycin (HMR 3647) enhances binding to both MLS-sensitive and-resistant ribosome. Poster No. 02.01. 2000.
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Douthwaite, S.1
Mauvaris, P.2
Haastrup Hansen, L.3
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133
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Interaction of macrolides and ketolides with the ribosome
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Mankin A., Xiong L., Khaitovich P. Interaction of macrolides and ketolides with the ribosome. Poster No. 01.02. 2000.
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Poster No. 01.02.
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Mankin, A.1
Xiong, L.2
Khaitovich, P.3
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135
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85184383327
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Pharmacokinetics of 800 mg once-daily oral dosing of the ketolide antibacterial telithromycin (HMR 3647) in healthy young subjects
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Presented at 5th ICMAS-KO
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Lenfant B., Sultan E., Wable C., Pascual M.H., Meyer B.H. Pharmacokinetics of 800 mg once-daily oral dosing of the ketolide antibacterial telithromycin (HMR 3647) in healthy young subjects. Poster No. 09.21. 2000.
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Lenfant, B.1
Sultan, E.2
Wable, C.3
Pascual, M.H.4
Meyer, B.H.5
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136
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Synthesis and antibacterial activity of 6-O-substituted ketolides
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Presented at 38th Intersci. Conf. Antimicrob. Agents Chemother
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Ma Z., Or Y.S., Clark R.F., Wang S., Brazzale A., Yong H., Tufano M., Nilius A.M., Bui M.-H., Raney P., Flamm R.K., Chu D.T.W., Plattner J.J. Synthesis and antibacterial activity of 6-O-substituted ketolides. Abstr. No. F-126. 1998.
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Ma, Z.1
Or, Y.S.2
Clark, R.F.3
Wang, S.4
Brazzale, A.5
Yong, H.6
Tufano, M.7
Nilius, A.M.8
Bui, M.-H.9
Raney, P.10
Flamm, R.K.11
Chu, D.T.W.12
Plattner, J.J.13
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137
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Design, synthesis, and characterization of ABT-773: A novel ketolide highly active against multidrug-resistant pathogens
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Presented at 39th Intersci. Conf. Antimicrob. Agents Chemother
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Ma Z., Clark R.F., Or Y. Design, synthesis, and characterization of ABT-773: A novel ketolide highly active against multidrug-resistant pathogens. Abstr. No. 2133 1999.
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Abstr. No. 2133
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Clark, R.F.2
Or, Y.3
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138
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The in vitro activity of ABT-773 against gram-positive respiratory pathogens
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Shortridge D., Ramer N.C., Beyer J., Ma Z., Or Y., Flamm R.K. the in vitro activity of ABT-773 against gram-positive respiratory pathogens. Poster No. 02.17. 2000.
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Poster No. 02.17.
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Shortridge, D.1
Ramer, N.C.2
Beyer, J.3
Ma, Z.4
Or, Y.5
Flamm, R.K.6
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139
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The in vitro activity of ABT-773 against gram-negative respiratory pathogens
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Presented at 5th ICMAS-KO
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Shortridge D., Ramer N.C., Beyer J., Ma Z., Or Y., Flamm R.K. The in vitro activity of ABT-773 against gram-negative respiratory pathogens. Poster No. 02.28. 2000.
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Poster No. 02.28.
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Shortridge, D.1
Ramer, N.C.2
Beyer, J.3
Ma, Z.4
Or, Y.5
Flamm, R.K.6
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140
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In vivo evaluations of ABT-773 and HMR-3647 against respiratory pathogens in murine and rat models of infection
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Presented at 5th ICMAS-KO
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Mitten M., Meulbroek J., Paige L., Nukkala M., Mollison K.W., Nilius A.M., Flamm R.K., Ma Z., Djuric S. In vivo evaluations of ABT-773 and HMR-3647 against respiratory pathogens in murine and rat models of infection. Poster No. 03.10. 2000.
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Poster No. 03.10.
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Mitten, M.1
Meulbroek, J.2
Paige, L.3
Nukkala, M.4
Mollison, K.W.5
Nilius, A.M.6
Flamm, R.K.7
Ma, Z.8
Djuric, S.9
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141
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Presented at 5th ICMAS-KO
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Strigl S., Roblin P.M., Reznik T., Hammerschlag M.R. In vitro activity of ABT-773, a new ketolide antibiotic, against Chlamydia pneumoniae. Poster No. 02.32. 2000.
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Strigl, S.1
Roblin, P.M.2
Reznik, T.3
Hammerschlag, M.R.4
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142
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85184376570
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Intracellular activity and post-antibiotic effect of ABT-773 against Legionella
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Dubois J., St.Pierre C. Intracellular activity and post-antibiotic effect of ABT-773 against Legionella. Poster No. 02.33. 2000.
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Poster No. 02.33.
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Dubois, J.1
PierreSt, C.2
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143
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85184359702
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Activity of ABT-773 against Mycobacterium avium complex in the Beige mouse model
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Presented at 5th ICMAS-KO
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Cynamon M.H., Carter J.L., Shoen C.M. Activity of ABT-773 against Mycobacterium avium complex in the Beige mouse model. Poster No. 03.14. 2000.
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Cynamon, M.H.1
Carter, J.L.2
Shoen, C.M.3
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144
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85184363979
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The ketolide ABT-773 protects against lethal Toxoplasma gondii
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Presented at 5th ICMAS-KO
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Khan A.A., Araujo F.G., Craft J.C. The ketolide ABT-773 protects against lethal Toxoplasma gondii. Poster No. 03.07. 2000.
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Poster No. 03.07.
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Khan, A.A.1
Araujo, F.G.2
Craft, J.C.3
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145
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Pharmacokinetics of ABT-773 in mouse, rat, monkey and dog
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Hernandez L., Krill S., Ma Z., Marsh K. Pharmacokinetics of ABT-773 in mouse, rat, monkey and dog. Poster No. 09.33. 2000.
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Hernandez, L.1
Krill, S.2
Ma, Z.3
Marsh, K.4
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146
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0033978875
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In vitro activity of ABT-773, a new ketolide, against recent clinical isolaters of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis
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Brueggemann A.B., Doern G.V., Huynh H.K., Wingert E.M., Rhomberg P.R. In vitro activity of ABT-773, a new ketolide, against recent clinical isolaters of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Antimicrob. Agents Chemother. 2000, 44:447-449.
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Antimicrob. Agents Chemother.
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Brueggemann, A.B.1
Doern, G.V.2
Huynh, H.K.3
Wingert, E.M.4
Rhomberg, P.R.5
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147
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In vitro activity of telithromycin (HMR 3647), a new ketolide, against clinical isolates of Mycoplasma pneumoniae in Japan
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Yamaguchi T., Hirakata Y., Izumikawa K., Miyazaki Y., Maesaki S., Tomono K., Yamada Y., Kamihira S., Kohno S. In vitro activity of telithromycin (HMR 3647), a new ketolide, against clinical isolates of Mycoplasma pneumoniae in Japan. Antimicrob. Agents Chemother. 2000, 44:1381-1382.
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Yamaguchi, T.1
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148
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Strigl S., Robin P.M., Renznik T., Hammerschlag M.R. In vitro activity of ABT-773, a new ketolide antibiotic, against Chlamydia pneumoniae. Antimicrob. Agents Chemother. 2000, 44:1112-1113.
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In vitro activities of ketolide HMR 3647 and HMR 3004, Levofloxacin, and other quinolones and macrolides against, Neisseria spp. and Moraxella catarrhalis
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Saez-Nieto J.A., Vazquez J.A. In vitro activities of ketolide HMR 3647 and HMR 3004, Levofloxacin, and other quinolones and macrolides against, Neisseria spp. and Moraxella catarrhalis. Antimicrob. Agents Chemother. 1999, 43:983-984.
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Cynamon M.H., Carter J.L., Shoen C.M. Activity of ABT-773 against Mycobacterium avium complex in the Beige mouse model. Antimicrob. Agents Chemother. 2000, 44:2895-2896.
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Consigny S., Bentoucha A., Bonnafous P., Grosset J., Ji B. Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice. Antimicrob. Agents Chemother. 2000, 44:2919-2921.
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In vitro activities of telithromycin (HMR3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis
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Rolain J.-M., Maurin M., Bryskier A., Raoult D. In vitro activities of telithromycin (HMR3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis. Antimicrob. Agents Chemother. 2000, 44:1391-1393.
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Gia H.P., Roeder V., Namour F., Sultan E., Lenfant B. Telithromycin (HMR 3647) achieves high and sustained concentrations in white blood cells in man. Poster No. 09.27 2000.
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Lenfant, B.5
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155
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Cao Z., Hammond R., Pratt S., Saiki A., Lerner C., Zhong P. Mechanism of action for novel ketolide ABT-773. Abstr. No. F-2135. 1999.
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Capobianco J.O., Shortridge V., Ma Z., Phan L., Or Y., Zhong P. Rapid drug accumulation of ABT-773 in Streptococcus pneumoniae. Abstr. No. 2137 1999.
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Lerner, C.5
Flamm, R.6
Zhong, P.7
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Bin X.X., Wolf K., Schaffner T., Malinverni R. Effect of azithromycin plus rifampin versus amoxicillin alone on eradication and inflammation in the chronic course of Chlamydia pneumoniae pneumonitis in mice. Antimicrob. Agents Chemother. 2000, 44:1761-1764.
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Pendland S.L., Prause J.L., Neuhauser M.M., Boyea N., Hackleman J.M., Danziger L.H. In vitro activity of ABT-773, a new ketolide antibiotic, alone and in combination with metronidazole, amoxicillin, or tetracycline against Helicobacter pylori. Abstr. No. F-2145. 1999.
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Jung R., Messick C.R., Pendland S.L., Tesoro E.P., Losendahl K.J., Schriever C.A., Danziger L.H. Postantibiotic effects and bactericidal activities of clarithromycin-14-hydroxyl-clarithromycin, versus those of amoxicillin-clavulanate, against anaerobes. Antimicrob. Agents Chemother. 2000, 44:778-779.
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Neuhauser M.M., Prause J.L., Jung R., Boyea N., Hackleman J.M., Danziger L.H., Pendland S.L. In vitro bactericidal activity of ABT-773, a new ketolide, versus clarithromycin (CL) and azithromycin (AZ) against penicillin/erythromycin-sensitive and-resistant Streptococcus pneumoniae (SP). Abstr. No. 2139 1999.
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Kadota J., Ishimatsu Y., Iwashita T., Matsubara Y., Kohno S., Tateno M., Ishihara R. The ketolide antimicrobial, telithromycin (HMR 3647), achieves high and sustained concentration in alveolar macrophages and bronchoalveolar epitherial lining fluid in healthy Japanese volunteers. Abstr. No. 2143 2000.
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Deabate C.A., Heyder A., Leroy B., Sidadous E., Backstrom J. Oral telithromycin (HMR 3647; 800mg od) for 5 days is well tolerated and as effective as cefuroxime axetil (500 mg bid) for 10 days in adults with acute exacerbations of chronic bronchitis (AECB). Abstr. No. L-2228. 2000.
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