Synthesis and biological activity of 4″-O-acyl derivatives of 14- and 15-membered macrolides linked to ω-quinolone-carboxylic unit

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6547-6558

  Kugor, Maja Matanović ^a   Timac, Vlado ^a   Palej, Ivana ^a   Lugarić, Urdjica ^a   Paljetak, Hana Ipić ^a   Filić, Darko ^a   Modrić, Marina ^a   Ilović, Ivica ^b   Gembarovski, Dubravka ^a   Mutak, Stjepan ^d   Eraković Haber, Vesna ^a   Holmes, David J ^c   Ivezić Schoenfeld, Zrinka ^d   Alihodić, Sulejman ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c GLAXOSMITHKLINE   (United States)

^d PLIVA Research Institute Ltd   (Croatia)

Author keywords

Antibacterial activity; Macrolide; Quinolone; Resistance

Indexed keywords

11 AMINO 11 N,12 O CARBONYL 4'' O [3 [2 [3 (3 CARBOXY 1 ETHYL 4 OXO 1,4 DIHYDROQUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONY] 11 DESOXY 6 O METHYL ERYTHROMYCIN A; 11 N,12 O CARBONYL 4'' O [3 [2 [3 (3 CARBOXY 1 ETHYL 4 OXO 1,4 DIHYDROQUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONYL] 11 DESOXY 6 O METHYL 11 METHYLAMINO ERYTHROMYCIN A; 4'' O [3 [2 [3 (3 CARBOXY 1 CYCLOPROPYL 4 OXO 1,4 DIHYDRO QUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 4'' O [3 [2 [3 (3 CARBOXY 1 ETHYL 4 OXO 1,4 DIHYDROQUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONYL] 6 O METHYL 8A AZA 8A HOMOERYTHROMYCIN A; 4'' O [3 [2 [3 (3 CARBOXY 1 ETHYL 4 OXO 1,4 DIHYDROQUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 4'' O [3 [2 [3 (3 CARBOXY 1 ETHYL 4 OXO 1,4 DIHYDROQUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONYL]CLARITHROMYCIN; 4'' O [3 [2 [3 (3 CARBOXY 1 ETHYL 4 OXO 1,4 DIHYDROQUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONYL]ROXYTHROMYCIN; 4'' O [3 [2 [3 (3 CARBOXY 4 OXO 1 PROPYL 1,4 DIHYDROQUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 9 ETHYLOXYMINO 4'' O [3 [2 [3 (3 CARBOXY 1 ETHYL 4 OXO 1,4 DIHYDROQUINOLINE 6 YL)PROPOXY]ETHOXY]PROPIONYL]ERYTHROMYCIN A; ANTIINFECTIVE AGENT; AZITHROMYCIN; CARBOXYLIC ACID DERIVATIVE; MACROLIDE; QUINOLONE DERIVATIVE; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; HAEMOPHILUS INFLUENZAE; IN VITRO STUDY; IN VIVO STUDY; MALE; MORAXELLA CATARRHALIS; NONHUMAN; PLASMA CLEARANCE; RAT; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; HUMANS; MACROLIDES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955981663     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.050     Document Type: Article

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