메뉴 건너뛰기




Volumn 20, Issue 4, 2010, Pages 415-422

Substrate and drug binding sites in LeuT

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; ATOMOXETINE; CITALOPRAM; CLOMIPRAMINE; COCAINE; DESIPRAMINE; DOPAMINE TRANSPORTER; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; LEUCINE TRANSPORTER; NEUROTRANSMITTER; NISOXETINE; NORADRENALIN TRANSPORTER; PAROXETINE; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRICYCLIC ANTIDEPRESSANT AGENT; TRYPTOPHAN; UNCLASSIFIED DRUG;

EID: 77955981124     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sbi.2010.05.007     Document Type: Review
Times cited : (34)

References (51)
  • 1
    • 0001951796 scopus 로고    scopus 로고
    • Mechanisms of biogenic amine neurotransmitter transporters
    • Humana Press, M.E.A. Reith (Ed.)
    • Rudnick G. Mechanisms of biogenic amine neurotransmitter transporters. Neurotransmitter Transporters: Structure, Function, and Regulation 2002, 25-52. Humana Press. edn 2. M.E.A. Reith (Ed.).
    • (2002) Neurotransmitter Transporters: Structure, Function, and Regulation , pp. 25-52
    • Rudnick, G.1
  • 2
    • 0037264650 scopus 로고    scopus 로고
    • Plasma membrane monoamine transporters: structure, regulation and function
    • Torres G.E., Gainetdinov R.R., Caron M.G. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci 2003, 4:13-25.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 13-25
    • Torres, G.E.1    Gainetdinov, R.R.2    Caron, M.G.3
  • 3
    • 44849091207 scopus 로고    scopus 로고
    • Sodium-coupled neurotransmitter transporters
    • Kanner B.I., Zomot E. Sodium-coupled neurotransmitter transporters. Chem Rev 2008, 108:1654-1668.
    • (2008) Chem Rev , vol.108 , pp. 1654-1668
    • Kanner, B.I.1    Zomot, E.2
  • 7
    • 35148815052 scopus 로고    scopus 로고
    • Mechanism of chloride interaction with neurotransmitter:sodium symporters
    • Zomot E., Bendahan A., Quick M., Zhao Y., Javitch J.A., Kanner B.I. Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature 2007, 449:726-730.
    • (2007) Nature , vol.449 , pp. 726-730
    • Zomot, E.1    Bendahan, A.2    Quick, M.3    Zhao, Y.4    Javitch, J.A.5    Kanner, B.I.6
  • 9
    • 34548684744 scopus 로고    scopus 로고
    • LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
    • Zhou Z., Zhen J., Karpowich N.K., Goetz R.M., Law C.J., Reith M.E., Wang D.N. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science 2007, 317:1390-1393.
    • (2007) Science , vol.317 , pp. 1390-1393
    • Zhou, Z.1    Zhen, J.2    Karpowich, N.K.3    Goetz, R.M.4    Law, C.J.5    Reith, M.E.6    Wang, D.N.7
  • 10
    • 34548178234 scopus 로고    scopus 로고
    • Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
    • Singh S.K., Yamashita A., Gouaux E. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 2007, 448:952-956.
    • (2007) Nature , vol.448 , pp. 952-956
    • Singh, S.K.1    Yamashita, A.2    Gouaux, E.3
  • 11
    • 41449093586 scopus 로고    scopus 로고
    • Substrate binding and formation of an occluded state in the leucine transporter
    • Celik L., Schiott B., Tajkhorshid E. Substrate binding and formation of an occluded state in the leucine transporter. Biophys J 2008, 94:1600-1612.
    • (2008) Biophys J , vol.94 , pp. 1600-1612
    • Celik, L.1    Schiott, B.2    Tajkhorshid, E.3
  • 12
    • 77950476282 scopus 로고    scopus 로고
    • Crystal structure of the carnitine transporter and insights into the antiport mechanism
    • Tang L., Bai L., Wang W.H., Jiang T. Crystal structure of the carnitine transporter and insights into the antiport mechanism. Nat Struct Mol Biol 2010, 17:492-496.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 492-496
    • Tang, L.1    Bai, L.2    Wang, W.H.3    Jiang, T.4
  • 13
    • 49449116748 scopus 로고    scopus 로고
    • Structural biology. Symmetric transporters for asymmetric transport
    • Karpowich N.K., Wang D.N. Structural biology. Symmetric transporters for asymmetric transport. Science 2008, 321:781-782.
    • (2008) Science , vol.321 , pp. 781-782
    • Karpowich, N.K.1    Wang, D.N.2
  • 14
    • 77349101044 scopus 로고    scopus 로고
    • Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter
    • Schmitt K.C., Mamidyala S., Biswas S., Dutta A.K., Reith M.E. Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter. J Neurochem 2010, 112:1605-1618.
    • (2010) J Neurochem , vol.112 , pp. 1605-1618
    • Schmitt, K.C.1    Mamidyala, S.2    Biswas, S.3    Dutta, A.K.4    Reith, M.E.5
  • 16
    • 0018757033 scopus 로고
    • Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport
    • Talvenheimo J., Nelson P.J., Rudnick G. Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport. J Biol Chem 1979, 254:4631-4635.
    • (1979) J Biol Chem , vol.254 , pp. 4631-4635
    • Talvenheimo, J.1    Nelson, P.J.2    Rudnick, G.3
  • 17
    • 67349282342 scopus 로고    scopus 로고
    • Antidepressants specificity of serotonin transporter suggested by three LeuT-SSRI complex structures
    • Zhou Z., Zhen J., Karpowich N.K., Law C.J., Reith M.E., Wang D.N. Antidepressants specificity of serotonin transporter suggested by three LeuT-SSRI complex structures. Nat Struct Mol Biol 2009, 16:652-657.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 652-657
    • Zhou, Z.1    Zhen, J.2    Karpowich, N.K.3    Law, C.J.4    Reith, M.E.5    Wang, D.N.6
  • 18
    • 0035896596 scopus 로고    scopus 로고
    • Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity
    • Roubert C., Cox P.J., Bruss M., Hamon M., Bonisch H., Giros B. Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity. J Biol Chem 2001, 276:8254-8260.
    • (2001) J Biol Chem , vol.276 , pp. 8254-8260
    • Roubert, C.1    Cox, P.J.2    Bruss, M.3    Hamon, M.4    Bonisch, H.5    Giros, B.6
  • 19
    • 0029860223 scopus 로고    scopus 로고
    • Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter
    • Barker E.L., Blakely R.D. Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter. Mol Pharmacol 1996, 50:957-965.
    • (1996) Mol Pharmacol , vol.50 , pp. 957-965
    • Barker, E.L.1    Blakely, R.D.2
  • 20
    • 33644856545 scopus 로고    scopus 로고
    • Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants
    • Henry L.K., Field J.R., Adkins E.M., Parnas M.L., Vaughan R.A., Zou M.F., Newman A.H., Blakely R.D. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. J Biol Chem 2006, 281:2012-2023.
    • (2006) J Biol Chem , vol.281 , pp. 2012-2023
    • Henry, L.K.1    Field, J.R.2    Adkins, E.M.3    Parnas, M.L.4    Vaughan, R.A.5    Zou, M.F.6    Newman, A.H.7    Blakely, R.D.8
  • 21
    • 44249099473 scopus 로고    scopus 로고
    • Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition
    • Walline C.C., Nichols D.E., Carroll F.I., Barker E.L. Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition. J Pharmacol Exp Ther 2008, 325:791-800.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 791-800
    • Walline, C.C.1    Nichols, D.E.2    Carroll, F.I.3    Barker, E.L.4
  • 23
    • 20444413791 scopus 로고    scopus 로고
    • High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions
    • Plenge P., Wiborg O. High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions. Neurosci Lett 2005, 383:203-208.
    • (2005) Neurosci Lett , vol.383 , pp. 203-208
    • Plenge, P.1    Wiborg, O.2
  • 25
    • 65649109333 scopus 로고    scopus 로고
    • Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants
    • Andersen J., Taboureau O., Hansen K.B., Olsen L., Egebjerg J., Stromgaard K., Kristensen A.S. Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants. J Biol Chem 2009, 284:10276-10284.
    • (2009) J Biol Chem , vol.284 , pp. 10276-10284
    • Andersen, J.1    Taboureau, O.2    Hansen, K.B.3    Olsen, L.4    Egebjerg, J.5    Stromgaard, K.6    Kristensen, A.S.7
  • 27
    • 0022400048 scopus 로고
    • Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes
    • Plenge P., Mellerup E.T. Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes. Eur J Pharmacol 1985, 119:1-8.
    • (1985) Eur J Pharmacol , vol.119 , pp. 1-8
    • Plenge, P.1    Mellerup, E.T.2
  • 28
    • 52649124847 scopus 로고    scopus 로고
    • Driving forces for ligand migration in the leucine transporter
    • Jorgensen A.M., Topiol S. Driving forces for ligand migration in the leucine transporter. Chem Biol Drug Des 2008, 72:265-272.
    • (2008) Chem Biol Drug Des , vol.72 , pp. 265-272
    • Jorgensen, A.M.1    Topiol, S.2
  • 29
    • 20544452305 scopus 로고    scopus 로고
    • Ligand-protein interaction in biomembrane carriers. The induced transition fit of transport catalysis
    • Klingenberg M. Ligand-protein interaction in biomembrane carriers. The induced transition fit of transport catalysis. Biochemistry 2005, 44:8563-8570.
    • (2005) Biochemistry , vol.44 , pp. 8563-8570
    • Klingenberg, M.1
  • 30
    • 0031565115 scopus 로고    scopus 로고
    • Pharmacological profile of antidepressants and related compounds at human monoamine transporters
    • Tatsumi M., Groshan K., Blakely R.D., Richelson E. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 1997, 340:249-258.
    • (1997) Eur J Pharmacol , vol.340 , pp. 249-258
    • Tatsumi, M.1    Groshan, K.2    Blakely, R.D.3    Richelson, E.4
  • 31
    • 0032927199 scopus 로고    scopus 로고
    • Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type
    • Eshleman A.J., Carmolli M., Cumbay M., Martens C.R., Neve K.A., Janowsky A. Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type. J Pharmacol Exp Ther 1999, 289:877-885.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 877-885
    • Eshleman, A.J.1    Carmolli, M.2    Cumbay, M.3    Martens, C.R.4    Neve, K.A.5    Janowsky, A.6
  • 32
    • 0027399143 scopus 로고
    • Third-generation antidepressants
    • Pinder R.M., Wieringa J.H. Third-generation antidepressants. Med Res Rev 1993, 13:259-325.
    • (1993) Med Res Rev , vol.13 , pp. 259-325
    • Pinder, R.M.1    Wieringa, J.H.2
  • 33
    • 0242492097 scopus 로고    scopus 로고
    • Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis
    • Roman D.L., Walline C.C., Rodriguez G.J., Barker E.L. Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis. Eur J Pharmacol 2003, 479:53-63.
    • (2003) Eur J Pharmacol , vol.479 , pp. 53-63
    • Roman, D.L.1    Walline, C.C.2    Rodriguez, G.J.3    Barker, E.L.4
  • 34
    • 0021750251 scopus 로고
    • Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins
    • Welch W.M., Kraska A.R., Sarges R., Koe B.K. Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins. J Med Chem 1984, 27:1508-1515.
    • (1984) J Med Chem , vol.27 , pp. 1508-1515
    • Welch, W.M.1    Kraska, A.R.2    Sarges, R.3    Koe, B.K.4
  • 35
    • 0029029578 scopus 로고
    • Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication
    • Wong D.T., Bymaster F.P., Engleman E.A. Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci 1995, 57:411-441.
    • (1995) Life Sci , vol.57 , pp. 411-441
    • Wong, D.T.1    Bymaster, F.P.2    Engleman, E.A.3
  • 36
    • 0028923912 scopus 로고
    • Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors
    • Wong D.T., Bymaster F.P. Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors. Adv Exp Med Biol 1995, 363:77-95.
    • (1995) Adv Exp Med Biol , vol.363 , pp. 77-95
    • Wong, D.T.1    Bymaster, F.P.2
  • 38
    • 43949130429 scopus 로고    scopus 로고
    • From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies
    • Eildal J.N., Andersen J., Kristensen A.S., Jorgensen A.M., Bang-Andersen B., Jorgensen M., Stromgaard K. From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J Med Chem 2008, 51:3045-3048.
    • (2008) J Med Chem , vol.51 , pp. 3045-3048
    • Eildal, J.N.1    Andersen, J.2    Kristensen, A.S.3    Jorgensen, A.M.4    Bang-Andersen, B.5    Jorgensen, M.6    Stromgaard, K.7
  • 39
    • 0028307423 scopus 로고
    • A new pharmophoric model for 5-HT reuptake-inhibitors: differentiation of amphetamine analogues
    • Rupp A., Kovar K.A., Beuerle G., Ruf C., Folkers G. A new pharmophoric model for 5-HT reuptake-inhibitors: differentiation of amphetamine analogues. Pharm Acta Helv 1994, 68:235-244.
    • (1994) Pharm Acta Helv , vol.68 , pp. 235-244
    • Rupp, A.1    Kovar, K.A.2    Beuerle, G.3    Ruf, C.4    Folkers, G.5
  • 40
    • 52449098689 scopus 로고    scopus 로고
    • Recent developments in the design of anti-depressive therapies: targeting the serotonin transporter
    • Butler S.G., Meegan M.J. Recent developments in the design of anti-depressive therapies: targeting the serotonin transporter. Curr Med Chem 2008, 15:1737-1761.
    • (2008) Curr Med Chem , vol.15 , pp. 1737-1761
    • Butler, S.G.1    Meegan, M.J.2
  • 41
    • 0031820091 scopus 로고    scopus 로고
    • Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine
    • Heal D.J., Aspley S., Prow M.R., Jackson H.C., Martin K.F., Cheetham S.C. Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine. Int J Obes Relat Metab Disord 1998, 22(Suppl. 1):S18-S28.
    • (1998) Int J Obes Relat Metab Disord , vol.22 , Issue.SUPPL. 1
    • Heal, D.J.1    Aspley, S.2    Prow, M.R.3    Jackson, H.C.4    Martin, K.F.5    Cheetham, S.C.6
  • 42
    • 0032981063 scopus 로고    scopus 로고
    • Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding
    • Sanchez C., Hyttel J. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell Mol Neurobiol 1999, 19:467-489.
    • (1999) Cell Mol Neurobiol , vol.19 , pp. 467-489
    • Sanchez, C.1    Hyttel, J.2
  • 43
    • 0036764594 scopus 로고    scopus 로고
    • The monoamine reuptake blocker brasofensine reverses akinesia without dyskinesia in MPTP-treated and levodopa-primed common marmosets
    • Pearce R.K., Smith L.A., Jackson M.J., Banerji T., Scheel-Kruger J., Jenner P. The monoamine reuptake blocker brasofensine reverses akinesia without dyskinesia in MPTP-treated and levodopa-primed common marmosets. Mov Disord 2002, 17:877-886.
    • (2002) Mov Disord , vol.17 , pp. 877-886
    • Pearce, R.K.1    Smith, L.A.2    Jackson, M.J.3    Banerji, T.4    Scheel-Kruger, J.5    Jenner, P.6
  • 44
    • 34250680833 scopus 로고    scopus 로고
    • Population pharmacokinetic modelling of NS2330 (tesofensine) and its major metabolite in patients with Alzheimer's disease
    • Lehr T., Staab A., Tillmann C., Trommeshauser D., Raschig A., Schaefer H.G., Kloft C. Population pharmacokinetic modelling of NS2330 (tesofensine) and its major metabolite in patients with Alzheimer's disease. Br J Clin Pharmacol 2007, 64:36-48.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 36-48
    • Lehr, T.1    Staab, A.2    Tillmann, C.3    Trommeshauser, D.4    Raschig, A.5    Schaefer, H.G.6    Kloft, C.7
  • 45
    • 0033984392 scopus 로고    scopus 로고
    • Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse
    • Rothman R.B., Partilla J.S., Baumann M.H., Dersch C.M., Carroll F.I., Rice K.C. Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse. Synapse 2000, 35:222-227.
    • (2000) Synapse , vol.35 , pp. 222-227
    • Rothman, R.B.1    Partilla, J.S.2    Baumann, M.H.3    Dersch, C.M.4    Carroll, F.I.5    Rice, K.C.6
  • 46
    • 12244291291 scopus 로고    scopus 로고
    • Antidepressant-like actions of DOV 21,947: a " triple" reuptake inhibitor
    • Skolnick P., Popik P., Janowsky A., Beer B., Lippa A.S. Antidepressant-like actions of DOV 21,947: a " triple" reuptake inhibitor. Eur J Pharmacol 2003, 461:99-104.
    • (2003) Eur J Pharmacol , vol.461 , pp. 99-104
    • Skolnick, P.1    Popik, P.2    Janowsky, A.3    Beer, B.4    Lippa, A.S.5
  • 47
    • 58149233796 scopus 로고    scopus 로고
    • A competitive inhibitor traps LeuT in an open-to-out conformation
    • Singh S.K., Piscitelli C.L., Yamashita A., Gouaux E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 2008, 322:1655-1660.
    • (2008) Science , vol.322 , pp. 1655-1660
    • Singh, S.K.1    Piscitelli, C.L.2    Yamashita, A.3    Gouaux, E.4
  • 48
    • 0023265754 scopus 로고
    • Cocaine receptors on dopamine transporters are related to self-administration of cocaine
    • Ritz M.C., Lamb R.J., Goldberg S.R., Kuhar M.J. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 1987, 237:1219-1223.
    • (1987) Science , vol.237 , pp. 1219-1223
    • Ritz, M.C.1    Lamb, R.J.2    Goldberg, S.R.3    Kuhar, M.J.4
  • 49
    • 0035882478 scopus 로고    scopus 로고
    • Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission
    • Wu Q., Reith M.E., Kuhar M.J., Carroll F.I., Garris P.A. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. J Neurosci 2001, 21:6338-6347.
    • (2001) J Neurosci , vol.21 , pp. 6338-6347
    • Wu, Q.1    Reith, M.E.2    Kuhar, M.J.3    Carroll, F.I.4    Garris, P.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.