GABA transporter lysine 448: A key residue for tricyclic antidepressants interaction

Cellular and Molecular Life Sciences

Volumn 66, Issue 23, 2009, Pages 3797-3808

  Cherubino, Francesca ^a,b   Miszner, Andreea ^a   Renna, Maria Daniela ^a   Sangaletti, Rachele ^a   Giovannardi, Stefano ^a   Bossi, Elena ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b IRCCS   (Italy)

Author keywords

Antidepressant; Electrophysiology; GAT1; SLC6A1; Uncompetitive inhibition

Indexed keywords

4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID CARRIER LYSINE 488; ASPARTIC ACID; CLOMIPRAMINE; DESIPRAMINE; FLUOXETINE; GLUTAMIC ACID; IMIPRAMINE; LYSINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG EFFICACY; ELECTRIC CURRENT; ELECTROPHYSIOLOGY; EMBRYO; HUMAN; HUMAN CELL; NONHUMAN; OOCYTE; STEADY STATE; WILD TYPE; XENOPUS LAEVIS;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CELL LINE; ELECTROPHYSIOLOGY; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; POINT MUTATION; RATS; SEROTONIN UPTAKE INHIBITORS; XENOPUS LAEVIS;

RATTUS; XENOPUS LAEVIS;

EID: 70749089925     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0153-9     Document Type: Article

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