Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 2, 1999, Pages 877-885

  Eshleman, Amy J ^a,c   Carmolli, Marya ^b   Cumbay, Medhane ^b   Martens, Carey R ^b   Neve, Kim A ^a,b   Janowsky, Aaron ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; IMIPRAMINE; MAZINDOL; NEUROTRANSMITTER; NORADRENALIN; RADIOLIGAND; SEROTONIN;

AMINE TRANSPORT; BINDING AFFINITY; CELL TYPE; CONFERENCE PAPER; DRUG ABUSE; DRUG EFFECT; DRUG POTENCY; HUMAN; HUMAN CELL; LIGAND BINDING; NEUROTRANSMISSION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING;

CARRIER PROTEINS; CELL LINE; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FLUOXETINE; HUMANS; IODINE RADIOISOTOPES; KIDNEY; KINETICS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; RADIOLIGAND ASSAY; RECOMBINANT PROTEINS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STEREOISOMERISM; SYMPORTERS;

EID: 0032927199     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (40)

1. Amara SG and Kuhar MJ (1993) Neurotransmitter transporters: Recent progress Annu Rev Neurosci 16:73-93.
2. Barker EL, Kimmel HL and Blakely RD (1994) Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Mol Pharmacol 46:798-807.
3. Boja J, Markham L, Patel A, Uhl G and Kuhar MJ (1992a) Expression of a single dopamine transporter cDNA can confer two cocaine binding sites. NeuroReport 3:247-248.
4. 125I]RTI-SS to dopamine and serotonin transporters in rat brain. Synapse 12:27-36.
5. Buck KJ and Amara SG (1995) Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants. Mo Pharmacol 48:1030-1037.
6. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
7. Downie NM and Heath RW (1974) Basic Statistical Methods, 4th ed. Harper & Row, New York.
8. Eshleman AJ, Henningsen RA, Neve KA and Janowsky A (1994) Release of dopamine via the human transporter. Mol Pharmacol 45:312-316.
9. Eshleman AJ, Neve RL, Janowsky A and Neve KA (1995) Characterization of a recombinant human dopamine transporter in multiple cell lines. J Pharmacol Exp Ther 274:276-283.
10. Fox BS (1997) Development of a therapeutic vaccine for the treatment of cocaine addiction. Drug Alcohol Depend 48:153-158.
11. Galli A, DeFelice LJ, Duke B-D, Moore KR and Blakely RD (1995) Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants. J Exp Biol 198:2197-2212.
12. Gawin FH, Kleber HD, Byck R, Rounsaville BJ, Kosten TR, Jatlow PI and Morgan C (1989) Desipramine facilitation of initial cocaine abstinence. Arch Gen Psych 46:117-121.
13. Giros B, Wang Y-M, Suter S, McLeskey SB, Pifl C and Caron MG (1994) Delineation of discrete domains for substrate, cocaine and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. J Biol Chem 269:15985-15988.
14. Giros B, Jaber M, Jones SR, Wightman RM and Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (London) 379:606-612.
15. Glowa JR, Fantegrossi WE, Lewis DB, Matecka D, Rice KC and Rothman RB (1996) Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl)piperazinyl decanoate, a long-acting ester derivative of GBR 12909. J Med Chem 39:4689-4690.
16. Gorelick DA (1997) Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy. Drug Alcohol Depend 48:159-165.
17. Jones SR, Gainetdinov RR, Wightman RM and Caron MG (1998) Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci 18:1979-1986.
18. Kitayama S, Shimada S, Xu H, Markham L, Donovan DM and Uhl GR (1992) Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci USA 89:7782-7785.
19. Kuhar MJ, Ritz MC and Boja JW (1991) The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci 14:299-302.
20. Limbird LE (1996) Cell Surface Receptors: A Short Course on Theory and Methods, 2nd ed. Kluwer Academic Publishers, Nowell, MA.
21. 125I]RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain. J Neurochem 61:1996-2006.
22. Morgan AE and Dewey SL (1998) Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine. Synapse 28:60-65.
23. Patel A, Uhl G, Kuhar MJ (1993) Species differences in dopamine transporters: postmortem changes and glycosylation differences. J Neurochem 61:496-500.
24. Preston KL, Sullivan JT, Berger P and Bigelow GE (1993) Effects of cocaine alone and in combination with mazindol in human cocaine abusers. J Pharmacol Exp Ther 267:296-307.
25. Qian Y, Galli A, Ramamoorthy S, Risso S, DeFelice LJ and Blakely RD (1997) Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J Neurosci 17:45-57.
26. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V and Blakely RD (1993) Antidepressant- and cocaine-sensitive human serotonin transporter. Molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90:2542-2546.
27. Richelson E and Pfenning M (1984) Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: Most antidepressants selectively block norepinephrine uptake. Eur J Pharmacol 104:277-286.
28. Ritz M, Lamb R, Goldberg S, Kuhar M (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science (Wash DC) 237:1219-1223.
29. Roberts DC (1993) Self-administration of GBR 12909 and cocaine on cocaine-maintained behavior in rhesus monkey. Drug Alcohol Depend 33:31-39.
30. 3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists. Life Sci 63:267-272.
31. 125I]RTI-55. J Pharmacol Exp Ther 270:296-309.
32. Slusher BS, Tiffany CW, Olkowski JL and Jackson PF (1997) Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists. Drug Alcohol Depend 48:43-50.
33. Sora I, Wichems C, Takahashi N, Li XF, Zeng Z, Revay R, Lesch KP, Murphy DL and Uhl GR (1998) Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci USA 95:7699-7704.
34. 125I]RTI-55: In vitro binding and autoradiographic characterization. J Neurochem 62:549-556.
35. Tatsumi M, Groshan K, Blakely RD and Richelson E (1997) Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-258.
36. 3H]Nisoxetine: A new radioligand for norepinephrine uptake sites in brain. Eur J Pharmacol 191:239-243.
37. Tella SR, Ladenheim B, Andrews AM, Goldberg SR and Cadet JL (1996) Differential reinforcing effects of cocaine and GBR-12909: Biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system. J Neurosci 16: 7416-7427.
38. Vocci F, Chiang CN, Cummings L and Hawks R (1995) Overview: Medications development for the treatment of drug abuse. NIDA Res Monogr 149:4-15.
39. Volkow ND, Wang G-J, Fischman MW, Rolint RW, Fowler JS, Abumrad NN, Vitkun S, Lognad J, Gatley SJ, Pappas N, Hitzemann R and Shea CE (1997) Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature (London) 388:827-830.
40. Wojnicki FH and Glowa JR (1996) Effects of drug history on the acquisition of responding maintained by GBR 12909 in rhesus monkeys. Psychopharmacology 123:34-41.