Enhanced expression of p53 in reactive astrocytes following transient focal ischemia

Neurological Research

Volumn 24, Issue 3, 2002, Pages 324-328

  Chung, Y H ^a   Shin, C M ^a   Kim, M J ^a   Young Lee, E ^b   Kim, G ^b   Cha, C I ^a,c  

^a Seoul National University   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

^c Korea National Institute of Health   (South Korea)

Author keywords

Astrocytes; Cerebral ischemia; Hippocampus; Immunohistochemistry; p53; Rat

Indexed keywords

PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN ISCHEMIA; CELL DEATH; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DEGENERATIVE DISEASE; GLIA CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; ASTROCYTES; BRAIN; BRAIN CHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; RATS; RATS, SPRAGUE-DAWLEY; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 0036219828     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164102101199828     Document Type: Article

References (25)

1. Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: Evidence for apoptosis during selective neuronal loss
2. Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation
3. Nuclear accumulation of p53 protein following kainic acid-induced seizures
4. Differential expression of the immediate early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia
5. Induction of tumour suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment
6. Evidence for p53-mediated modulation of neuronal viability
7. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
8. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
9. 2+ channels in reactive astrocytes after ischemic injury in rats
10. 2+ channels in gerbil global cerebral ischemia
11. Rat middle cerebral artery occlusion using an intraluminal thread technique
12. P53- and CD95-associated apoptosis in neurodegenerative diseases
13. Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
14. Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis
15. Reactive astrocytes express nitric oxide synthase in the spinal cord of transgenic mice expressing a human Cu/Zn SOD mutation
16. Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/ Zn SOD mutation
17. Reactive astrocytes express p53 in the spinal cord of transgenic mice expressing a human Cu/Zn SOD mutation
18. Hypoxia-induced apoptosis: Effect of hypoxic severity and role of p53 in neuronal cell death
19. Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery
20. A role for the tumour suppressor gene p53 in regulating neuronal apoptosis
21. Granule cell apoptosis and protein expression in hippocampal dentate gyrus after forebrain ischemia in the rat
22. Photochemical brain injury in rats triggers DNA fragmentation p53 and HSP72
23. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
24. Changes of p53 in the brains of patients with Alzheimer's disease
25. Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells