Peripheral mechanisms underlying the essential role of P2X7 receptors in the development of inflammatory hyperalgesia

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 55-60

  Teixeira, Juliana Maia ^a   Oliveira, Maria Cláudia G ^a   Parada, Carlos Amílcar ^a   Tambeli, Cláudia Herrera ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

ATP; Carrageenan; Cytokine; Mechanical inflammatory hyperalgesia; P2X7 receptor

Indexed keywords

A 438079; ADENOSINE TRIPHOSPHATE; CARRAGEENAN; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HYPERALGESIA; MALE; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; RAT; SENSITIZATION; SUBCUTANEOUS TISSUE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRAGEENAN; CHEMOKINE CXCL1; DISEASE MODELS, ANIMAL; HYPERALGESIA; INFLAMMATION; INTERLEUKIN-6; MALE; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2X7; TETRAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955771114     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.061     Document Type: Article

References (58)

1. Baraldi P.G., del Carmen Nunez M., Morelli A., Falzoni S., Di Virgilio F., Romagnoli R. Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor. J. Med. Chem. 2003, 46:1318-1329.
2. Bulanova E., Budagian V., Orinska Z., Koch-Nolte F., Haag F., Bulfone-Paus S. ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells. J. Leukoc. Biol. 2009, 85:692-702.
3. Caporali F., Capecchi P.L., Gamberucci A., Lazzerini P.E., Pompella G., Natale M., Lorenzini S., Selvi E., Galeazzi M., Laghi Pasini F. Human rheumatoid synoviocytes express functional P2X7 receptors. J. Mol. Med. (Berlin, Germany) 2008, 86:937-949.
4. Chessell I.P., Hatcher J.P., Bountra C., Michel A.D., Hughes J.P., Green P., Egerton J., Murfin M., Richardson J., Peck W.L., Grahames C.B., Casula M.A., Yiangou Y., Birch R., Anand P., Buell G.N. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 2005, 114:386-396.
5. Chiozzi P., Sanz J.M., Ferrari D., Falzoni S., Aleotti A., Buell G.N., Collo G., Di Virgilio F. Spontaneous cell fusion in macrophage cultures expressing high levels of the P2Z/P2X7 receptor. J. Cell Biol. 1997, 138:697-706.
6. Collo G., Neidhart S., Kawashima E., Kosco-Vilbois M., North R.A., Buell G. Tissue distribution of the P2X7 receptor. Neuropharmacology 1997, 36:1277-1283.
7. Colomar A., Marty V., Medina C., Combe C., Parnet P., Amedee T. Maturation and release of interleukin-1beta by lipopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors. J. Biol. Chem. 2003, 278:30732-30740.
8. Cunha F.Q., Lorenzetti B.B., Poole S., Ferreira S.H. Interleukin-8 as a mediator of sympathetic pain. Br. J. Pharmacol. 1991, 104:765-767.
9. Cunha F.Q., Poole S., Lorenzetti B.B., Ferreira S.H. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 1992, 107:660-664.
10. Dell'Antonio G., Quattrini A., Cin E.D., Fulgenzi A., Ferrero M.E. Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP. Arthritis Rheum. 2002, 46:3378-3385.
11. Dell'Antonio G., Quattrini A., Dal Cin E., Fulgenzi A., Ferrero M.E. Antinociceptive effect of a new P(2Z)/P2X7 antagonist, oxidized ATP, in arthritic rats. Neurosci. Lett. 2002, 327:87-90.
12. Di Virgilio F. Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only target. Br. J. Pharmacol. 2003, 140:441-443.
13. Donnelly-Roberts D.L., Jarvis M.F. Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br. J. Pharmacol. 2007, 151:571-579.
14. Ferrari D., Villalba M., Chiozzi P., Falzoni S., Ricciardi-Castagnoli P., Di Virgilio F. Mouse microglial cells express a plasma membrane pore gated by extracellular ATP. J. Immunol. 1996, 156:1531-1539.
15. Ferrari D., Chiozzi P., Falzoni S., Dal Susino M., Melchiorri L., Baricordi O.R., Di Virgilio F. Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J. Immunol. 1997, 159:1451-1458.
16. Ferreira S.H., Moncada S., Parsons M., Vane J.R. Proceedings: the concomitant release of bradykinin and prostaglandin in the inflammatory response to carrageenin. Br. J. Pharmacol. 1974, 52:108P-109P.
17. Ferreira S.H., Lorenzetti B.B., Cunha F.Q., Poole S. Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia. Agents Actions 38 Spec No, C7-9 1993.
18. Fulgenzi A., Dell'Antonio G., Foglieni C., Dal Cin E., Ticozzi P., Franzone J.S., Ferrero M.E. Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP. BMC Immunol. 2005, 6:18.
19. Fulgenzi A., Ticozzi P., Gabel C.A., Dell Antonio G., Quattrini A., Franzone J.S., Ferrero M.E. Periodate oxidized ATP (OATP) reduces hyperalgesia in mice: involvement of P2X7 receptors and implications for therapy. Int. J. Immunopathol. Pharmacol. 2008, 21:61-71.
20. Gold M.S., Shuster M.J., Levine J.D. Role of a Ca(2+)-dependent slow after hyperpolarization in prostaglandin E2-induced sensitization of cultured rat sensory neurons. Neurosci. Lett. 1996, 205:161-164.
21. Gourine A.V., Poputnikov D.M., Zhernosek N., Melenchuk E.V., Gerstberger R., Spyer K.M., Gourine V.N. P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats. Br. J. Pharmacol. 2005, 146:139-145.
22. Gu B.J., Zhang W.Y., Bendall L.J., Chessell I.P., Buell G.N., Wiley J.S. Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors. Am. J. Physiol. Cell Physiol. 2000, 279:C1189-C1197.
23. Hama A., Woon Lee J., Sagen J. Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats. Eur. J. Pharmacol. 2003, 459:49-58.
24. Hide I., Tanaka M., Inoue A., Nakajima K., Kohsaka S., Inoue K., Nakata Y. Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J. Neurochem. 2000, 75:965-972.
25. Honore P., Donnelly-Roberts D., Namovic M.T., Hsieh G., Zhu C.Z., Mikusa J.P., Hernandez G., Zhong C., Gauvin D.M., Chandran P., Harris R., Medrano A.P., Carroll W., Marsh K., Sullivan J.P., Faltynek C.R., Jarvis M.F. A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2, 2-dimethylpropyl)-2-(3, 4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J. Pharmacol. Exp. Ther. 2006, 319:1376-1385.
26. Honore P., Donnelly-Roberts D., Namovic M., Zhong C., Wade C., Chandran P., Zhu C., Carroll W., Perez-Medrano A., Iwakura Y., Jarvis M.F. The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice. Behav. Brain Res. 2009, 204:77-81.
27. Huang C., Hu Z.P., Long H., Shi Y.S., Han J.S., Wan Y. Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain. Brain Res. Bull. 2004, 63:99-103.
28. Jarvis M.F., Khakh B.S. ATP-gated P2X cation-channels. Neuropharmacology 2009, 56:208-215.
29. Kahlenberg J.M., Dubyak G.R. Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am. J. Physiol. Cell Physiol. 2004, 286:C1100-C1108.
30. Kanai Y., Hara T., Imai A., Sakakibara A. Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia. J. Pharm. Pharmacol. 2007, 59:733-738.
31. Kim M., Spelta V., Sim J., North R.A., Surprenant A. Differential assembly of rat purinergic P2X7 receptor in immune cells of the brain and periphery. J. Biol. Chem. 2001, 276:23262-23267.
32. Lister M.F., Sharkey J., Sawatzky D.A., Hodgkiss J.P., Davidson D.J., Rossi A.G., Finlayson K. The role of the purinergic P2X7 receptor in inflammation. J. Inflamm. (Lond.) 2007, 4:5.
33. Loram L.C., Fuller A., Fick L.G., Cartmell T., Poole S., Mitchell D. Cytokine profiles during carrageenan-induced inflammatory hyperalgesia in rat muscle and hind paw. J. Pain 2007, 8:127-136.
34. Lorenzetti B.B., Veiga F.H., Canetti C.A., Poole S., Cunha F.Q., Ferreira S.H. Cytokine-induced neutrophil chemoattractant 1 (CINC-1) mediates the sympathetic component of inflammatory mechanical hypersensitivity in rats. Eur. Cytokine Netw. 2002, 13:456-461.
35. Mancino G., Placido R., Di Virgilio F. P2X7 receptors and apoptosis in tuberculosis infection. J. Biol. Regul. Homeost. Agents 2001, 15:286-293.
36. McGaraughty S., Wismer C.T., Zhu C.Z., Mikusa J., Honore P., Chu K.L., Lee C.H., Faltynek C.R., Jarvis M.F. Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration. Br. J. Pharmacol. 2003, 140:1381-1388.
37. McGaraughty S., Chu K.L., Namovic M.T., Donnelly-Roberts D.L., Harris R.R., Zhang X.F., Shieh C.C., Wismer C.T., Zhu C.Z., Gauvin D.M., Fabiyi A.C., Honore P., Gregg R.J., Kort M.E., Nelson D.W., Carroll W.A., Marsh K., Faltynek C.R., Jarvis M.F. P2X7-related modulation of pathological nociception in rats. Neuroscience 2007, 146:1817-1828.
38. Mingam R., De Smedt V., Amedee T., Bluthe R.M., Kelley K.W., Dantzer R., Laye S. In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain. Brain Behav. Immun. 2008, 22:234-244.
39. Moncada S., Ferreira S.H., Vane J.R. Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature 1973, 246:217-219.
40. Nelson D.W., Gregg R.J., Kort M.E., Perez-Medrano A., Voight E.A., Wang Y., Grayson G., Namovic M.T., Donnelly-Roberts D.L., Niforatos W., Honore P., Jarvis M.F., Faltynek C.R., Carroll W.A. Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J. Med. Chem. 2006, 49:3659-3666.
41. North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 2002, 82:1013-1067.
42. Oliveira M.C., Parada C.A., Veiga M.C., Rodrigues L.R., Barros S.P., Tambeli C.H. Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain. Eur. J. Pain 2005, 9:87-93.
43. Oliveira M.C., Pelegrini-da-Silva A., Parada C.A., Tambeli C.H. 5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue. Neuroscience 2007, 145:708-714.
44. Oliveira M.C., Pelegrini-da-Silva A., Tambeli C.H., Parada C.A. Peripheral mechanisms underlying the essential role of P2X3, 2/3 receptors in the development of inflammatory hyperalgesia. Pain 2009, 141:127-134.
45. Otuki M.F., Ferreira J., Lima F.V., Meyre-Silva C., Malheiros A., Muller L.A., Cani G.S., Santos A.R., Yunes R.A., Calixto J.B. Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. J. Pharmacol. Exp. Ther. 2005, 313:310-318.
46. Parada C.A., Yeh J.J., Joseph E.K., Levine J.D. Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. Eur. J. Neurosci. 2003, 17:1847-1852.
47. Randall L.O., Selitto J.J. A method for measurement of analgesic activity on inflamed tissue. Arch. Int. Pharmacodyn. Ther. 1957, 111:409-419.
48. Rosland J.H. The formalin test in mice: the influence of ambient temperature. Pain 1991, 45:211-216.
49. Rush A.M., Waxman S.G. PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins. Brain Res. 2004, 1023:264-271.
50. Safieh-Garabedian B., Poole S., Allchorne A., Winter J., Woolf C.J. Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br. J. Pharmacol. 1995, 115:1265-1275.
51. Sanz J.M., Di Virgilio F. Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J. Immunol. 2000, 164:4893-4898.
52. Sim J.A., Young M.T., Sung H.Y., North R.A., Surprenant A. Reanalysis of P2X7 receptor expression in rodent brain. J. Neurosci. 2004, 24:6307-6314.
53. Solle M., Labasi J., Perregaux D.G., Stam E., Petrushova N., Koller B.H., Griffiths R.J., Gabel C.A. Altered cytokine production in mice lacking P2X(7) receptors. J. Biol. Chem. 2001, 276:125-132.
54. Spraggins D.S., Turnbach M.E., Randich A. Effects of glutamate receptor antagonists on spinal dorsal horn neurons during zymosan-induced inflammation in rats. J. Pain 2001, 2:12-24.
55. Surprenant A., Rassendren F., Kawashima E., North R.A., Buell G. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 1996, 272:735-738.
56. Zhang X.F., Han P., Faltynek C.R., Jarvis M.F., Shieh C.C. Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia. Brain Res. 2005, 1052:63-70.
57. Zheng J.H., Chen J. Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat. Neuropeptides 2001, 35:32-44.
58. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.