Periodate oxidized ATP (oATP) reduces hyperalgesia in mice: Involvement of P2X7 receptors and implications for therapy

International Journal of Immunopathology and Pharmacology

Volumn 21, Issue 1, 2008, Pages 61-71

  Fulgenzi, A ^a   Ticozzi, P ^a   Gabel, C A ^b   Dell'Antonio, G ^c   Quattrini, A ^c   Franzone, J S ^d   Ferrera, Maria Elena ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b PFIZER INC   (United States)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d Medestea Research   (Italy)

Author keywords

Arthritic pain; Neuropathic pain; oATP; P2X7 receptors; Visceral pain

Indexed keywords

ADENOSINE TRIPHOSPHATE; PERIODATE; PURINERGIC P2X7 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HYPERALGESIA; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; THERMAL STIMULATION; VISCERAL PAIN;

EID: 41849125991     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200802100108     Document Type: Article

References (40)

1. Kennedy C. and P. Leff. 1995. How should P2X purinoceptors be classified pharmacologically? Trends Pharmacol. Sci. 16:168.
2. Dunn P.M., Y. Zhong and G. Burnstock. 2001. P2X receptors in peripheral neurons. Prog. Neurobiol. 65: 107.
3. Dowd E., D.S. McQueen, I.P. Chessell and P.P. Humphrey. 1998. P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint. Br. J. Pharmacol. 125:341.
4. Burnstock G. 2000. P2X receptors in sensory neurones. Br. J. Anaesth. 84:476.
5. Dai Y., T. Fukuoka, H. Wang, H. Yamanaka, K. Obata, A. Tokunaga and K. Noguchi. 2004. Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons. Pain 108: 258.
6. North R.A. 2002. Molecular physiology of P2X receptors. Physiol. Rev. 82:1013.
7. Gu B.J., W.Y. Zhang, L.J. Bendall, I.P. Chessell, G.N. Buell and J.S. Wiley. 2000. Related Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors. Am. J. Physiol. Cell Physiol. 279:1189.
8. Deuchars S.A., L. Atkinson, R.E. Brooke, H. Musa, C.J. Milligan, T.F. Batten, N.J. Buckley, S.H. Parson and J. Deuchars. 2001. Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems. J. Neurosci. 21:7143.
9. Sim J.A., M.T. Young, H.Y. Sung, R.A. North and A. Surprenant. 2004. Reanalysis of P2X7 receptor expression in rodent brain. J. Neurosci. 24:6307.
10. Guerra A.N., P.L. Fisette, Z.A. Pfeiffer, B.H. Quinchia-Rios, U. Prabhu, M. Aga, L.C. Denlinger, A.G. Guadarrama, S. Abozeid, J.A. Sommer, R.A. Proctor and P.J. Bertics. 2003. Purinergic receptor regulation of LPS-induced signaling and pathophysiology. J. Endotoxin Res. 9: 256.
11. Rothwell N. 2003. Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behav. Immun. 17:152.
12. Watkins L.R., S.F. Maier and L.E. Goehler. 1995. Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain 63:289.
13. Murgia M., S. Hanau, P. Pizzo, M. Rippa and F. Di Virgilio. 1993. Oxidized ATP: an irreversible inhibitor of the macrophage purinergic P2Z receptor. J. Biol. Chem. 268:8199.
14. Solini A., E. Santini, D. Chimenti, P. Chiozzi, F. Pratesi, S. Cuccato, S. Falzoni, R. Lupi, E. Ferrannini, G. Pugliese and F. Di Virgilio. 2007. Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4. Am. J. Physiol. Renal. Physiol. 292:1537.
15. Colman R.F. 1990. Affinity labeling of nucleotide binding sites of enzymes and platelets. Adv. Exp. Med. Biol. 281:257.
16. Lowe P.N. and R.B. Beechey. 1982. Interactions between the mitochondrial adenosinetriphosphatase and periodate-oxidized adenosine 5′-triphosphate, an affinity label for adenosine 5′-triphosphate binding sites. Biochemistry 21:4073.
17. Dell'Antonio G., A. Quattrini, E. Dal Cin, A. Fulgenzi and M.E. Ferrero. 2002. Antinociceptive effect of a new P(2Z)/P2X7 antagonist, oxidized ATP, in arthritic rats. Neurosci. Lett. 327:87.
18. Dell'Antonio G., A. Quattrini, E. Dal Cin, A. Fulgenzi and M.E. Ferrero. 2002. Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP. Arthritis Rheum. 46:3378.
19. Fulgenzi A., G. Dell'Antonio, C. Foglieni, E. Dal Cin, P. Ticozzi, J.S. Franzone and M.E. Ferrero. 2005. Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP. BMC Immunol. 6:18.
20. Terato K., D.S. Harper, M.M. Griffiths, D.L. Hasty, X.J. Ye, M.A. Cremer and J.M. Seyer. 1995. Collagen-induced arthritis in mice: synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen. Autoimmunity 22:137.
21. Ji R.R. and G. Strichartz. 2004. Cell signaling and the genesis of neuropathic pain. Sci. STKE. 252:14
22. Sommer C. 2004. Serotonin in pain and analgesia: actions in the periphery. Mol. Neurobiol. 30:117.
23. Abbadie C. 2005. Chemokines, chemokine receptors and pain. Trends Immunol. 26:529.
24. Beyak M.J. and S. Vanner. 2005. Inflammation-induced hyperexcitability of nociceptive gastrointestinal DRG neurones: the role of voltage-gated ion channels. Neurogastroenterol. Motil. 17:175.
25. Vera-Portocarrero L. and K.N. Westlund. 2005. Role of neurogenic inflammation in pancreatitis and pancreatic pain. Neurosignals 14:158.
26. Solle M., J. Labasi, D.G. Perregaux, E. Stam, N. Petrushova, B.H. Koller, R.J. Griffiths and C.A. Gabel. 2001. Altered cytokine production in mice lacking P2X(7) receptors. J. Biol. Chem. 276:125.
27. Labasi J.M., N. Petrushova, C. Donovan, S. McCurdy, P. Lira, M.M. Payette, W. Brissette, J.R. Wicks, L. Audoly and C.A. Gabel. 2002. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168:6436.
28. Chessell I.P., J.P. Hatcher, C. Bountra, A.D. Michel, J.P. Hughes, P. Green, J. Egerton, M. Murfin, J. Richardson, W.L. Peck, C.B. Grahames, M.A. Casula, Y. Yiangou, R. Birch, P. Anand and G.N. Buell. 2005. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114:386.
29. Beigi R.D., S.B. Kertesy, G. Aquilina and G.R. Dubyak. 2003. Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms. Br. J. Pharmacol. 140: 507.
30. Zimmermann M. 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109.
31. Hargreaves K., R. Dubner, F. Brown, C. Flores and J. Joris. 1988. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77.
32. Collo G., S. Neidhart, E. Kawashima, M. Kosco-Vilbois, R.A. North and G. Buell. 1997. Tissue distribution of the P2X7 receptor. Neuropharmacology 36:1277.
33. Chen Y., G.W. Li, C. Wang, Y. Gu and L.Y. Huang. 2005. Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain 119:38.
34. Burnstock G. 2006. Purinergic P2 receptors as targets for novel analgesics. Pharmacol. Ther. 110: 433.
35. Galligan J.J. and R.A. North. 2004. Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system. Neurogastroenterol Motil. 16:64.
36. Hu H.Z., N. Gao, Z. Lin, C. Gao, S. Liu, J. Ren, Y. Xia and J.D. Wood. 2001. P2X(7) receptors in the enteric nervous system of guinea-pig small intestine. J. Comp. Neurol. 440:299.
37. Covey W.C., T.A. Ignatowski, P.R. Knight and R.N. Spengler. 2000. Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain. Brain Res. 859:113.
38. Costa B., A.E. Trovato, M. Colleoni, G. Piagnoni, E. Zarini and T. Croci. 2005. Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve. Pain 116:52.
39. Mahgoub A., A. El-Medany, A. Mustafa, M. Arafah and M. Moursi. 2005. Azithromycin and erythromycin ameliorate the extent of colonic damage induced by acetic acid in rats. Toxicol. Appl. Pharmacol. 205:43.
40. Gunosewoyo H., M.J. Closter and M. Kassiou. 2007. Molecular probes for P2X7 receptor studies. Curr. Med. Chem. 14:1505.