Design and synthesis of heterobimetallic topoisomerase I and II inhibitor complexes: In vitro DNA binding, interaction with 5′-GMP and 5′-TMP and cleavage studies

Journal of Photochemistry and Photobiology B: Biology

Volumn 101, Issue 1, 2010, Pages 37-46

  Arjmand, Farukh ^a   Muddassir, Mohd ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

5 GMP; 5 TMP; Cleavage studies; Heterobimetallic complexes; In vitro binding studies; Topoisomerases inhibition

Indexed keywords

COPPER COMPLEX; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; ETHIDIUM BROMIDE; GUANOSINE PHOSPHATE; THYMIDINE PHOSPHATE; TIN DERIVATIVE; ZINC COMPLEX;

ARTICLE; CANCER CHEMOTHERAPY; DNA HELIX; DRUG DESIGN; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; IN VITRO STUDY; INHIBITION KINETICS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

5'-GUANYLIC ACID; BINDING SITES; COORDINATION COMPLEXES; DNA; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROPHOTOMETRY, INFRARED; STATIC ELECTRICITY; THYMIDINE MONOPHOSPHATE; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 77955661271     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jphotobiol.2010.06.009     Document Type: Article

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