Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1, 10-phenanthroline and 3-methyl-picolinic acid

BioMetals

Volumn 23, Issue 1, 2010, Pages 99-118

  Seng, Hoi Ling ^a   Von, Sze Tin ^a   Tan, Kong Wai ^b   Maah, Mohd Jamil ^b   Ng, Seik Weng ^b   Rahman, Raja Noor Zaliha Raja Abd ^c   Caracelli, Ignez ^d   Ng, Chew Hee ^a  

^a UNIVERSITI TUNKU ABDUL RAHMAN   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Docking; Duplex and quadruplex DNA binding; Molecular modeling; Nucleolytic; Topo I inhibition; Zinc(II) ternary complex

Indexed keywords

1,10 PHENANTHROLINE; 3 METHYL PICOLINIC ACID; ASCORBIC ACID; DNA TOPOISOMERASE; GUANINE QUADRUPLEX; HYDROGEN PEROXIDE; NUCLEOPHILE; PICOLINIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZINC COMPLEX;

ARTICLE; BINDING SITE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DNA SEQUENCE; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; ASCORBIC ACID; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; HYDROGEN PEROXIDE; MODELS, CHEMICAL; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; PHENANTHROLINES; PICOLINIC ACIDS; PLASMIDS; ZINC;

EID: 77949423090     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-009-9271-y     Document Type: Article

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