DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition

Biochemistry

Volumn 38, Issue 47, 1999, Pages 15580-15586

  Fortune, John M ^a   Velea, Luminita ^b   Graves, David E ^b   Utsugi, Teruhiro ^c   Yamada, Yuji ^c   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 [2 (DIMETHYLAMINO)ETHYLAMINO] 3 HYDROXY 7H INDENO[2,1 C]QUINOLIN 7 ONE; ANTINEOPLASTIC AGENT; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING);

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL DESTRUCTION; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; AMINOQUINOLINES; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BINDING SITES; CATALYSIS; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA, FUNGAL; DNA, SUPERHELICAL; DNA-BINDING PROTEINS; HUMANS; INDENES; INTERCALATING AGENTS; ISOENZYMES; MODELS, MOLECULAR; PLASMIDS; SACCHAROMYCES CEREVISIAE;

MAMMALIA;

EID: 0033598702     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991792g     Document Type: Article

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