Biotechnological doxorubicin production: Pathway and regulation engineering of strains for enhanced production

Applied Microbiology and Biotechnology

Volumn 87, Issue 4, 2010, Pages 1187-1194

  Niraula, Narayan Prasad ^a   Kim, Seon Hye ^b   Sohng, Jae Kyung ^a   Kim, Eung Soo ^b  

^a SunMoon University   (South Korea)

^b Inha University   (South Korea)

Author keywords

Biosynthesis; Doxorubicin; Feedback regulation; Pathway engineering; Product inhibition; Regulatory engineering; Strain improvement

Indexed keywords

DOXORUBICIN; ENGINEERING STRAINS; FEEDBACK REGULATION; PRODUCT INHIBITION; REGULATORY ENGINEERING;

BIOCHEMISTRY; BIOSYNTHESIS; ENGINEERING; FERMENTATION; METABOLISM; METABOLITES;

LAWS AND LEGISLATION;

DAUNOSAMINE DERIVATIVE; DOXORUBICIN; EPSILON RHODOMYCINONE; THYMIDINE DIPHOSPHATE; THYMIDINE DIPHOSPHATE L DAUNOSAMINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC;

DRUG; EXPERIMENTAL STUDY; FERMENTATION; GENETIC ENGINEERING; MUTAGENICITY; SECONDARY METABOLITE;

DECARBOXYLATION; DRUG SYNTHESIS; GENE OVEREXPRESSION; GLYCOSYLATION; HYDROXYLATION; METHYLATION; NONHUMAN; REGULATOR GENE; SHORT SURVEY; STREPTOMYCES; STREPTOMYCES PEUCETIUS; STRUCTURAL GENE; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; METABOLISM; MICROBIOLOGY;

ANTIBIOTICS, ANTINEOPLASTIC; DOXORUBICIN; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENGINEERING; INDUSTRIAL MICROBIOLOGY; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES PEUCETIUS ATCC 27952;

EID: 77955551494     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2675-3     Document Type: Short Survey

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