Isolation and genetic manipulation of the antibiotic down-regulatory gene, wblA ortholog for doxorubicin-producing Streptomyces strain improvement

Applied Microbiology and Biotechnology

Volumn 86, Issue 4, 2010, Pages 1145-1153

  Noh, Jun Hee ^a   Kim, Seon Hye ^a   Lee, Han Na ^a   Lee, Sang Yup ^b   Kim, Eung Soo ^a  

^a Inha University   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Doxorubicin; Strain improvement; Streptomyces; WblA

Indexed keywords

DAUNORUBICIN; DNA MICROARRAY ANALYSIS; DOXORUBICIN; GENE DISRUPTIONS; GENETIC MANIPULATIONS; GENOME MICROARRAY; GENOMIC DNA; HYPOTHETICAL PROTEIN; MICROARRAY ANALYSIS; ORTHOLOGS; OVER-EXPRESSION; PUTATIVE TRANSCRIPTION FACTORS; REGULATORY GENES; S. COELICOLOR; STRAIN IMPROVEMENT; STREPTOMYCES COELICOLOR; TARGET GENES; TRANSCRIPTOME ANALYSIS; TRANSCRIPTOMICS;

AMINO ACIDS; ANTIBIOTICS; DNA; MICROARRAYS; ORGANIC ACIDS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

GENES;

AMINO ACID; DAUNORUBICIN; DOXORUBICIN; GENOMIC DNA;

AMINO ACID; BACTERIUM; COMPARATIVE STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; PROTEIN;

ARTICLE; BACTERIAL STRAIN; DNA LIBRARY; DNA MICROARRAY; DOWN REGULATION; GENE DISRUPTION; GENE EXPRESSION; GENE ISOLATION; GENETIC MANIPULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; SCREENING; STREPTOMYCES; STREPTOMYCES PEUCETIUS; TRANSCRIPTOMICS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; DAUNORUBICIN; DNA, BACTERIAL; DOXORUBICIN; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE KNOCKOUT TECHNIQUES; GENE LIBRARY; GENETIC ENGINEERING; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; UP-REGULATION;

STREPTOMYCES; STREPTOMYCES COELICOLOR; STREPTOMYCES PEUCETIUS;

EID: 77950628979     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2391-z     Document Type: Article

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