Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthetic pathway in Streptomyces peucetius ATCC 27952

Applied Microbiology and Biotechnology

Volumn 85, Issue 5, 2010, Pages 1565-1574

  Singh, Bijay ^a   Lee, Chang Beom ^a   Sohng, Jae Kyung ^a  

^a SunMoon University   (South Korea)

Author keywords

Daunosamine; Doxorubicin; Rhamnose; Streptomyces peucetius; TDP D glucose 4,6 dehydratase

Indexed keywords

BIOSYNTHETIC GENE CLUSTER; BIOSYNTHETIC PATHWAY; COMPLEMENTATION; D-GLUCOSE; DAUNOSAMINE; DOXORUBICIN; ENZYME ASSAYS; FRAMESHIFT; KNOCKOUT MUTANT; NUCLEOTIDE SUGAR; PREMATURE TERMINATION; SEQUENCE SIMILARITY; SUGAR MOIETY;

BIOCHEMISTRY; BIOSYNTHESIS; GENES; SUGAR (SUCROSE);

GLUCOSE;

BACTERIAL PROTEIN; DOXORUBICIN; GLUCOSE DERIVATIVE; RHAMNOSE; RMBB PROTEIN; UNCLASSIFIED DRUG;

BACTERIUM; BIOCHEMISTRY; DNA; GENE; GENOME; SUGAR;

ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; CATALYSIS; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INACTIVATION; GENE CLUSTER; GENE FUNCTION; GENE IDENTIFICATION; GENE INACTIVATION; GENE LOCATION; GENE SEQUENCE; GENE SILENCING; GENE SYNTHESIS; GENOME ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; SEQUENCE ANALYSIS; STREPTOMYCES; STREPTOMYCES PEUCETICUS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; BIOSYNTHETIC PATHWAYS; CLONING, MOLECULAR; DNA, BACTERIAL; DOXORUBICIN; ENZYME ASSAYS; ESCHERICHIA COLI; FRAMESHIFT MUTATION; GENE SILENCING; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; GLUCOSE; HEXOSAMINES; HYDRO-LYASES; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; RHAMNOSE; STREPTOMYCES; THYMINE NUCLEOTIDES; TRANSFORMATION, BACTERIAL;

STREPTOMYCES PEUCETIUS; STREPTOMYCES PEUCETIUS ATCC 27952;

EID: 76649116524     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2225-z     Document Type: Article

References (26)

1. I Aguirrezabalaga C Olano N Allende L Rodriguez AF Braña C Méndez JA Salas 2000 Identification and expression of genes involved in biosynthesis of L-Oleandrose and its intermediate L-Olivose in the oleandomycin producer Streptomyces antibioticus Antimicrob Agents Chemother 44 1266 1275 10.1128/AAC.44.5.1266-1275.2000 1:CAS:528:DC%2BD3cXislKisbc%3D (Pubitemid 30228304)
2. M Bierman R Logan K O'Brien ET Seno RN Rao BE Schoner 1992 Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp Gene 116 43 49 10.1016/0378-1119(92)90627-2 1:CAS:528:DyaK38XltVGgt74%3D
3. K Furuya CR Hutchinson 1998 The DrrC protein of Streptomyces peucetius, a UvrA-like protein, is a DNA-binding protein whose gene is induced by daunorubicin FEMS Microbiol Lett 168 243 249 10.1111/j.1574-6968.1998.tb13280.x 1:CAS:528:DyaK1cXnt1ejsr4%3D
4. MA Gallo J Wardlt CR Hutchinson 1996 The dnrM gene in Streptomyces peucetius contains a naturally occurring frameshift mutation that is suppressed by another locus outside of the daunorubicin-production gene cluster Microbiology 142 269 275 10.1099/13500872-142-2-269 1:CAS:528:DyaK28XhtlSisb4%3D
5. A Grimm K Madduri A Ali CR Hutchinson 1994 Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase Gene 151 1 10 10.1016/0378-1119(94)90625-4 1:CAS:528:DyaK2MXjtFSht7g%3D
6. DA Hopwood 1997 Genetic contribution to understanding polyketide synthase Chem Rev 97 2465 2497 10.1021/cr960034i 1:CAS:528:DyaK2sXntFWks7o%3D
7. CR Hutchinson AL Colombo 1999 Genetic engineering of doxorubicin production in Streptomyces peucetius: a review J Ind Microbiol Biotechnol 23 647 652 10.1038/sj.jim.2900673 1:CAS:528:DyaK1MXlt1eiurY%3D (Pubitemid 29397145)
8. H Jiang CR Hutchinson 2006 Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius Res Microbiol 157 666 674 10.1016/j.resmic.2006.02.004 1:CAS:528:DC%2BD28XotlKhsbw%3D (Pubitemid 44234070)
9. Kieser T, Mervyn JB, Mark BJ, Keith CF, Hopwood DA (2000) Practical Streptomyces genetics. John Innes Foundation Norwich, UK
10. KJ Linton BW Jarvis CR Hutchinson 1995 Cloning of the genes encoding thymidine diphosphoglucose 4, 6-dehydratase and thymidine diphospho-4-keto-6- deoxyglucose 3, 5-epimerase from the erythromycin-producing Saccharopolyspora erythraea Gene 153 33 40 10.1016/0378-1119(94)00809-7 1:CAS:528: DyaK2MXjs1CqtLk%3D
11. N Lomovskaya SL Otten Y Doi-Katayama L Fonstein XC Liu T Takatsu A Inventi-Solari S Filippini F Torti AL Colombo CR Hutchinson 1999 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene J Bacteriol 181 305 318 1:CAS:528:DyaK1MXitFWmuw%3D%3D
12. DJ MacNeil JL Occi KM Gewain T MacNeil PH Gibbons CL Rudy SJ Danis 1992 Complex organisation of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase Gene 115 119 125 10.1016/0378-1119(92)90549-5 1:CAS:528:DyaK38XlsVCmurc%3D
13. K Madduri CR Hutchinson 1995 Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius J Bacteriol 177 3879 3884 1:CAS:528:DyaK2MXmsFymu7g%3D
14. K Madduri C Waldron DJ Merlo 2001 Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa J Bacteriol 183 5632 5638 10.1128/JB.183.19.5632-5638.2001 1:CAS:528: DC%2BD3MXmvF2ms7g%3D (Pubitemid 32898609)
15. K Madduri C Waldron P Matsushima MC Broughton K Crawford DJ Merlo RH Baltz 2001 Genes for the biosynthesis of spinosyns: applications for yield improvement in Saccharopolyspora spinosa J Ind Microbiol Biotechnol 27 399 402 10.1038/sj.jim.7000180 1:CAS:528:DC%2BD38Xhsl2ntA%3D%3D (Pubitemid 34043009)
16. CL Marolda MA Valvano 1995 Genetic analysis of the dTDP-rhamnose biosynthesis region of the Escherichia coli VW187 (O7:K1) rfb gene cluster: identification of functional homologs of rfbB and rfbA in the rff cluster and correct location of the rffE gene J Bacteriol 177 5539 5546 1:CAS:528: DyaK2MXosVWmtr4%3D
17. SL Otten X Liu J Ferguson CR Hutchinson 1995 Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis J Bacteriol 177 6688 6692 1:CAS:528:DyaK2MXptlKrtLc%3D
18. SL Otten MA Gallo K Madduri XC Liu CR Hutchinson 1997 Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine J Bacteriol 179 4446 4450 1:CAS:528:DyaK2sXkt1Kksb8%3D
19. SL Otten C Olano CR Hutchinson 2000 The dnrO gene encodes a DNA-binding protein that regulates daunorubicin production in Streptomyces peucetius by controlling expression of the dnrN pseudo response regulator gene Microbiology 146 1457 1468 1:CAS:528:DC%2BD3cXktlWmt78%3D
20. S Peiru HG Menzella E RodrIguez J Carney H Gramajo 2005 Production of the potent antibacterial polyketide erythromycin C in Escherichia coli Appl Microbiol Biotechnol 71 2539 2547 1:CAS:528:DC%2BD2MXktFKmurs%3D
21. A Ramos F Lombó AF Braña J Rohr C Méndez JA Salas 2008 Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster Microbiology 154 781 788 10.1099/mic.0.2007/014035-0 1:CAS:528:DC%2BD1cXjvFers7k%3D (Pubitemid 351736292)
22. JA Salas C Mendez 2005 Biosynthesis pathways for desoxysugars in antibiotic-producing actinomycetes: isolation, characterization and generation of novel glycosylated derivatives J Mol Microbiol Biotechnol 9 77 85 10.1159/000088838 1:CAS:528:DC%2BD2MXht1KltLfF (Pubitemid 41682543)
23. Sambrook J, Russell DW (2001) Molecular cloning: a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
24. B Sthapit TJ Oh R Lamichhane KK Liou HC Lee CG Kim JK Sohng 2004 Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus FEBS Lett 566 201 206 10.1016/j.febslet.2004.04.033 1:CAS:528:DC%2BD2cXktVOksLs%3D (Pubitemid 38625958)
25. KJ Stutzman-Engwall SL Otten CR Hutchinson 1992 Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius J Bacteriol 174 144 154 1:CAS:528:DyaK3sXhs1Gjsrw%3D
26. A Trefzer JA Salas A Bechthold 1999 Genes and enzymes involved in deoxysugar biosynthesis in bacteria Nat Prod Rep 16 283 299 10.1039/a804431g 1:CAS:528:DyaK1MXjtF2jtrs%3D (Pubitemid 29280021)