Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius

Research in Microbiology

Volumn 161, Issue 2, 2010, Pages 109-117

  Malla, Sailesh ^a   Niraula, Narayan Prasad ^a   Liou, Kwangkyoung ^a   Sohng, Jae Kyung ^a  

^a SunMoon University   (South Korea)

Author keywords

Doxorubicin; Overexpression; Regulatory gene; Streptomyces peucetius

Indexed keywords

DAUNORUBICIN; DOXORUBICIN; EPSILON RHODOMYCINONE;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; EXPRESSION VECTOR; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RECOMBINANT PLASMID; REGULATOR GENE; STRAIN DIFFERENCE; STREPTOMYCES; STREPTOMYCES PEUCETIUS;

BIOSYNTHETIC PATHWAYS; DOXORUBICIN; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENGINEERING; HUMANS; MOLECULAR STRUCTURE; PLASMIDS; RECOMBINATION, GENETIC; STREPTOMYCES;

STREPTOMYCES PEUCETIUS;

EID: 77949913523     PISSN: 09232508     EISSN: 17697123     Source Type: Journal    
DOI: 10.1016/j.resmic.2009.12.003     Document Type: Article

References (27)

1. Arcamone F., Cassinelli G., Fantini G., Grein A., Orezzi P., Pol C., Spalla C. Adriamycin, 14-hydroxydaunomycin, a new antitumor antibiotic from Streptomyces peucetius var. caesius. Biotechnol. Bioeng. 1969, 11:1101-1110.
2. Chater K.F., Bibb M.J. Regulation of bacterial antibiotic production. Biotechnology: Products of Secondary Metabolism 1996, vol. 7:57-105. Wiley-VCH, Weinheim. H. Kleinkauf, H. von Döhren (Eds.).
3. Furuya K., Hutchinson C.R. The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis. J. Bacteriol. 1996, 178:6310-6318.
4. Grein A. Antitumor anthracyclines produced by Streptomyces peucetius. Adv. Appl. Microbiol. 1987, 32:203-214.
5. Huh J.H., Kim D.J., Zhao X.Q., Li M., Jo Y.Y., Yoon T.M., Shin S.K., Yong J.H., Ryu Y.W., Yang Y.Y., Suh J.W. Widespread activation of antibiotic biosynthesis by S-adenosylmethionine in Streptomycetes. FEMS Microbiol. Lett. 2004, 238:439-447.
6. Kieser T., Bibb M.J., Buttner M.J., Chater K.F., Hopwood D.A. Practical Streptomyces Genetics 2000, John Innes Foundation, Norwich.
7. Kim D.J., Huh J.H., Yang Y.Y., Kang C.M., Lee I.H., Hyun C.G., Hong S.K., Suh J.W. Accumulation of S-adenosyl-l-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23. J. Bacteriol. 2003, 185:592-600.
8. Lee J.C., Park H.R., Park D.J., Lee H.B., Kim Y.B., Kim C.J. Improved production of teicoplanin using adsorbent resin in fermentations. Lett. Appl. Microbiol. 2003, 37:196-200.
9. Lee P.C., Umeyama T., Horinouchi S. afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2). Mol. Microbiol. 2002, 43:1413-1430.
10. Lomovskaya N., Doi-Katayama Y., Filippini S., Nastro C., Fonstein L., Gallo M., Colombo A.L., Hutchinson C.R. The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis. J. Bacteriol. 1998, 180:2379-2386.
11. Maharjan S., Oh T.J., Lee H.C., Sohng J.K. Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin. Biotechnol. Lett. 2008, 30:1621-1626.
12. Malla S., Niraula N.P., Liou K., Sohng J.K. Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius. J. Biosci. Bioeng. 2009, 108:92-98.
13. Malla S., Niraula N.P., Liou K., Sohng J.K. Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement. Microbiol. Res. 2009, 10.1016/j.micres.2009.04.002.
14. Oh, T.J., Niraula, N.P., Liou, K. and Sohng, J.K. Identification of the duplicated genes for S-adenosyl-l-methionine synthetase (metK1-sp and metK2-sp) in Streptomyces peucetius var. caesius ATCC 27952. J Appl Microbiol. (Manuscript id: JAM-2009-0968, in press).
15. Okamoto S., Lezhava A., Hosaka T., Hosoya Y.O., Ochi K. Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). J. Bacteriol. 2003, 185:601-609.
16. Otten S.L., Ferguson J., Hutchinson C.R. Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus. J. Bacteriol. 1995, 177:1216-1224.
17. Parajuli N., Viet H.T., Ishida K., Tong H.T., Lee H.C., Liou K., Sohng J.K. Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952. Res. Microbiol. 2005, 156:707-712.
18. Sambrook J., Russell D.W. Molecular Cloning: A Laboratory Manual 2001, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. third ed.
19. Scotti C., Hutchinson C.R. Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis. J. Bacteriol. 1996, 178:7316-7321.
20. Shin S.K., Park H.S., Kwon H.J., Yoon H.J., Suh J.W. Genetic characterization of two S-adenosylmethionine-induced ABC transporters reveals their roles in modulations of secondary metabolism and sporulation in Streptomyces coelicolor M145. J. Microbiol. Biotechnol. 2007, 17:1818-1825.
21. Sthapit B., Oh T.J., Lamichhane R., Liou K., Lee H.C., Kim C.G., Sohng J.K. Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus. FEBS Lett. 2004, 566:201-206.
22. Stutzman-Engwall K.J., Otten S.L., Hutchinson C.R. Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. J. Bacteriol. 1992, 174:144-154.
23. Tanaka A., Takano Y., Ohnishi Y., Horinouchi S. AfsR recruits RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs. J. Mol. Biol. 2007, 369:322-333.
24. Tsueng, G., Lam, K.S. (2007) Stabilization effects of resin on the production of potent proteasome inhibitor NPI-0052 during submerged fermentation of Salinispora tropica. 60, 469-472.
25. Umeyama T., Lee P.C., Horinouchi S. Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces. Appl. Microbiol. Biotechnol. 2002, 59:419-425.
26. Walczak R.J., Dickens M.L., Priestley N.D., Strohl W.R. Purification, properties, and characterization of recombinant Streptomyces sp strain C5 DoxA, a cytochrome P450 catalyzing multiple steps in doxorubicin biosynthesis. J. Bacteriol. 1999, 181:298-304.
27. Zhao X.Q., Jin Y.Y., Kwon H.J., Yang Y.Y., Suh J.W. S-adenosylmethionine (SAM) regulates antibiotic biosynthesis in Streptomyces spp. in a mode independent of its role as a methyl donor. J. Microbiol. Biotechnol. 2006, 16:927-932.