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Volumn 181, Issue 2, 1999, Pages 642-647

The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; MITHRAMYCIN; POLYKETIDE;

EID: 0032902411     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.2.642-647.1999     Document Type: Article
Times cited : (72)

References (42)
  • 4
    • 0029908204 scopus 로고    scopus 로고
    • The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol
    • Belanger, A. E., G. S. Besra, M. E. Ford, K. Mikusova, J. T. Belisle, P. J. Brennan, and J. M. Inamine. 1996. The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc. Natl. Acad. Sci. USA 93:11919-11924.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11919-11924
    • Belanger, A.E.1    Besra, G.S.2    Ford, M.E.3    Mikusova, K.4    Belisle, J.T.5    Brennan, P.J.6    Inamine, J.M.7
  • 5
    • 0020448903 scopus 로고
    • Gene expression in Streptomyces: Construction and application of promoter-probe plasmid vectors in Streptomyces
    • Bibb, M. J., and S. N. Cohen. 1982. Gene expression in Streptomyces: construction and application of promoter-probe plasmid vectors in Streptomyces. Mol. Gen. Genet. 187:265-277.
    • (1982) Mol. Gen. Genet. , vol.187 , pp. 265-277
    • Bibb, M.J.1    Cohen, S.N.2
  • 6
    • 0022404392 scopus 로고
    • Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeus
    • Bibb, M. J., G. R. Janssen, and J. M. Ward. 1985. Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeus. Gene 38:215-226.
    • (1985) Gene , vol.38 , pp. 215-226
    • Bibb, M.J.1    Janssen, G.R.2    Ward, J.M.3
  • 7
    • 0030090909 scopus 로고    scopus 로고
    • Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of antitumor agents
    • Blanco, G., H. Fu, C. Méndez, C. Khosla, and J. A. Salas. 1996. Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of antitumor agents. Chem. Biol. 3:193-196.
    • (1996) Chem. Biol. , vol.3 , pp. 193-196
    • Blanco, G.1    Fu, H.2    Méndez, C.3    Khosla, C.4    Salas, J.A.5
  • 8
    • 0000182975 scopus 로고
    • XL1-blue: A high efficiency plasmid transforming recA escherichia coli strain with beta-galactosidase selection
    • Bullock, W. O., J. M. Fernández, and J. N. Short. 1987. XL1-Blue: a high efficiency plasmid transforming recA Escherichia coli strain with beta-galactosidase selection. BioTechniques 5:376.
    • (1987) BioTechniques , vol.5 , pp. 376
    • Bullock, W.O.1    Fernández, J.M.2    Short, J.N.3
  • 9
    • 0027507351 scopus 로고
    • Isolation and sequencing of Escherichia coli gene proP reveals unusual structural features of the osmoregulatory proline/ betaine transporter ProP
    • Culham, D. E., B. Lasby, A. G. Marangoni, J. L. Milner, B. A. Steer, R. W. Nues, and J. M. Wood. 1993. Isolation and sequencing of Escherichia coli gene proP reveals unusual structural features of the osmoregulatory proline/ betaine transporter ProP. J. Mol. Biol. 229:268-276.
    • (1993) J. Mol. Biol. , vol.229 , pp. 268-276
    • Culham, D.E.1    Lasby, B.2    Marangoni, A.G.3    Milner, J.L.4    Steer, B.A.5    Nues, R.W.6    Wood, J.M.7
  • 10
    • 0021760092 scopus 로고
    • A comprehensive set of sequence analysis programs for the VAX
    • Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:387-395.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 387-395
    • Devereux, J.1    Haeberli, P.2    Smithies, O.3
  • 11
    • 0023652060 scopus 로고
    • Gene cluster for streptomycin biosynthesis in Streptomyces griseus: Nucleotide sequence of three genes and analysis of transcriptional activity
    • Distler, J., A. Ebert, K. Mansouri, K. Pissowotzki, M. Stockmann, and W. Piepersberg. 1987. Gene cluster for streptomycin biosynthesis in Streptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity. Nucleic Acids Res. 15:8041-8056.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 8041-8056
    • Distler, J.1    Ebert, A.2    Mansouri, K.3    Pissowotzki, K.4    Stockmann, M.5    Piepersberg, W.6
  • 12
    • 0020556322 scopus 로고
    • Cloning of a Streptomyces gene for an O-methyltransferase involved in antibiotic biosynthesis
    • Feitelson, J. S., and D. A. Hopwood. 1983. Cloning of a Streptomyces gene for an O-methyltransferase involved in antibiotic biosynthesis. Mol. Gen. Genet. 190:394-398.
    • (1983) Mol. Gen. Genet. , vol.190 , pp. 394-398
    • Feitelson, J.S.1    Hopwood, D.A.2
  • 13
    • 0029840323 scopus 로고    scopus 로고
    • An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus
    • Fernández, E., F. Lombó, C. Méndez, and J. A. Salas. 1996. An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus. Mol. Gen. Genet. 251:692-698.
    • (1996) Mol. Gen. Genet. , vol.251 , pp. 692-698
    • Fernández, E.1    Lombó, F.2    Méndez, C.3    Salas, J.A.4
  • 14
    • 0031690038 scopus 로고    scopus 로고
    • Identification of two genes from Streptomyces argillaceus encoding two glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin
    • Fernández, E., U. Weißbach, C. Sánchez Reillo, A. F. Braña, C. Méndez, J. Rohr, and J. A. Salas. 1998. Identification of two genes from Streptomyces argillaceus encoding two glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin. J. Bacteriol. 180:4929-4937.
    • (1998) J. Bacteriol. , vol.180 , pp. 4929-4937
    • Fernández, E.1    Weißbach, U.2    Reillo, C.S.3    Braña, A.F.4    Méndez, C.5    Rohr, J.6    Salas, J.A.7
  • 16
    • 0025899144 scopus 로고
    • The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces
    • Fernández-Moreno, M. A., J. L. Caballero, D. A. Hopwood, and F. Malpartida. 1991. The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. Cell 66:769-780.
    • (1991) Cell , vol.66 , pp. 769-780
    • Fernández-Moreno, M.A.1    Caballero, J.L.2    Hopwood, D.A.3    Malpartida, F.4
  • 17
    • 0026633027 scopus 로고
    • Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens
    • Geistlich, M., R. Losick, J. R. Turner, and N. R. Rao. 1992 Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens. Mol. Microbiol. 6:2019-2029.
    • (1992) Mol. Microbiol. , vol.6 , pp. 2019-2029
    • Geistlich, M.1    Losick, R.2    Turner, J.R.3    Rao, N.R.4
  • 19
    • 0023503633 scopus 로고
    • Pleiotropical, morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2)
    • Lawlor, E. J., H. A. Baylis, and K. F. Chater. 1987. Pleiotropical, morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2). Genes Dev. 1:1305-1310.
    • (1987) Genes Dev. , vol.1 , pp. 1305-1310
    • Lawlor, E.J.1    Baylis, H.A.2    Chater, K.F.3
  • 20
    • 0026029699 scopus 로고
    • TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants
    • Leskiw, B. K., E. J. Lawlor, J. M. Fernández-Abalos, and K. F. Chater. 1991. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Proc. Natl. Acad. Sci. USA 88:184-189.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 184-189
    • Leskiw, B.K.1    Lawlor, E.J.2    Fernández-Abalos, J.M.3    Chater, K.F.4
  • 21
    • 0029934431 scopus 로고    scopus 로고
    • Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin
    • Lombó, F., G. Blanco, E. Fernández, C. Méndez, and J. A. Salas. 1996. Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin. Gene 172:87-91.
    • (1996) Gene , vol.172 , pp. 87-91
    • Lombó, F.1    Blanco, G.2    Fernández, E.3    Méndez, C.4    Salas, J.A.5
  • 22
    • 0030995327 scopus 로고    scopus 로고
    • Cloning and insertional inactivation of Streptomyces argillaceus genes involved in earliest steps of sugar biosynthesis of the antitumor polyketide mithramycin
    • Lombó, F., K. Siems, A. F. Braña, C. Méndez, K. Bindseil, and J. A. Salas. 1997. Cloning and insertional inactivation of Streptomyces argillaceus genes involved in earliest steps of sugar biosynthesis of the antitumor polyketide mithramycin. J. Bacteriol. 179:3354-3357.
    • (1997) J. Bacteriol. , vol.179 , pp. 3354-3357
    • Lombó, F.1    Siems, K.2    Braña, A.F.3    Méndez, C.4    Bindseil, K.5    Salas, J.A.6
  • 23
    • 0031568318 scopus 로고    scopus 로고
    • The DNA-binding domain of OmpR: Crystal structures of a winged helix transcription factor
    • Martinez-Hackert, E., and A. M. Stock. 1997. The DNA-binding domain of OmpR: crystal structures of a winged helix transcription factor. Structure 15:109-124.
    • (1997) Structure , vol.15 , pp. 109-124
    • Martinez-Hackert, E.1    Stock, A.M.2
  • 24
    • 0022596118 scopus 로고
    • Improvement of the dideoxy chain termination method of DNA sequencing by the dideoxy-7-deazaguanosine triphosphate in place of dGTP
    • Mizusawa, S., S. Nishimura, and F. Seila. 1986. Improvement of the dideoxy chain termination method of DNA sequencing by the dideoxy-7-deazaguanosine triphosphate in place of dGTP. Nucleic Acids Res. 14:1319-1324.
    • (1986) Nucleic Acids Res. , vol.14 , pp. 1319-1324
    • Mizusawa, S.1    Nishimura, S.2    Seila, F.3
  • 25
    • 0025117571 scopus 로고
    • Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2)
    • Narva, K. E., and J. S. Feitelson. 1990. Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2). J. Bacteriol. 172:326-333.
    • (1990) J. Bacteriol. , vol.172 , pp. 326-333
    • Narva, K.E.1    Feitelson, J.S.2
  • 26
    • 0030954966 scopus 로고    scopus 로고
    • A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results in overproduction of both β-lactam compounds
    • Pérez-Llarena, F. J., P. Liras, A. Rodríguez Garcia, and J. F. Martín. 1997. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both β-lactam compounds. J. Bacteriol. 179:2053-2059.
    • (1997) J. Bacteriol. , vol.179 , pp. 2053-2059
    • Pérez-Llarena, F.J.1    Liras, P.2    Garcia, A.R.3    Martín, J.F.4
  • 29
    • 0028874933 scopus 로고
    • The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites
    • Retzlaff, L., and J. Distler. 1995. The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites. Mol. Microbiol. 18:151-162.
    • (1995) Mol. Microbiol. , vol.18 , pp. 151-162
    • Retzlaff, L.1    Distler, J.2
  • 30
    • 0029744822 scopus 로고    scopus 로고
    • 4-Methyl phthalate catabolism in Burkholderia (Pseudomonas) cepacia Pc701: A gene encoding a phthalate-specific permease forms part of a novel gene cluster
    • Saint, C. P., and P. Romas. 1996. 4-Methyl phthalate catabolism in Burkholderia (Pseudomonas) cepacia Pc701: a gene encoding a phthalate-specific permease forms part of a novel gene cluster. Microbiology 142:2407-2418.
    • (1996) Microbiology , vol.142 , pp. 2407-2418
    • Saint, C.P.1    Romas, P.2
  • 33
    • 0000925453 scopus 로고
    • Antitumor antibiotics of the aureolic acid group: Chromomycin A3, mithramycin A, and olivomycin A
    • A. Aszalos (ed.). CRC Press, Inc., Boca Raton, Fla.
    • Skarbek, J. D., and M. K. Speedie. 1981. Antitumor antibiotics of the aureolic acid group: chromomycin A3, mithramycin A, and olivomycin A, p. 191-235. In A. Aszalos (ed.), Antitumor compounds of natural origin: chemistry and biochemistry, 8th ed., vol. 1. CRC Press, Inc., Boca Raton, Fla.
    • (1981) Antitumor Compounds of Natural Origin: Chemistry and Biochemistry, 8th Ed. , vol.1 , pp. 191-235
    • Skarbek, J.D.1    Speedie, M.K.2
  • 34
    • 0026537421 scopus 로고
    • Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius
    • Stutzman-Engwall, K. J., S. L. Otten, and C. R. Hutchinson. 1992. Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. J. Bacteriol. 174:144-154.
    • (1992) J. Bacteriol. , vol.174 , pp. 144-154
    • Stutzman-Engwall, K.J.1    Otten, S.L.2    Hutchinson, C.R.3
  • 35
    • 0029818342 scopus 로고    scopus 로고
    • Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius
    • Tang, L., A. Grimm, Y. X. Zhang, and C. R. Hutchinson. 1996. Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius. Mol. Microbiol. 22:801-813.
    • (1996) Mol. Microbiol. , vol.22 , pp. 801-813
    • Tang, L.1    Grimm, A.2    Zhang, Y.X.3    Hutchinson, C.R.4
  • 36
    • 0030111235 scopus 로고    scopus 로고
    • Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli
    • Tatusov, R., A. R. Mushegian, P. Bork, N. P. Brown, W. S. Hayes, M. Borodovsky, K. E. Rudd, and E. V. Koonin. 1996. Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli. Curr. Biol. 6:279-291.
    • (1996) Curr. Biol. , vol.6 , pp. 279-291
    • Tatusov, R.1    Mushegian, A.R.2    Bork, P.3    Brown, N.P.4    Hayes, W.S.5    Borodovsky, M.6    Rudd, K.E.7    Koonin, E.V.8
  • 37
    • 0020451893 scopus 로고
    • Physical analysis of antibiotic-resistance genes from Streptomyces and their use in vector construction
    • Thompson, C. J., T. Kieser, J. M. Ward, and D. A. Hopwood. 1982. Physical analysis of antibiotic-resistance genes from Streptomyces and their use in vector construction. Gene 20:51-62.
    • (1982) Gene , vol.20 , pp. 51-62
    • Thompson, C.J.1    Kieser, T.2    Ward, J.M.3    Hopwood, D.A.4
  • 38
    • 0024419124 scopus 로고
    • Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)
    • Vara, J., M. Lewandowska-Skarbek, Y.-G. Wang, S. Donadio, and C. R. Hutchinson. 1989. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J. Bacteriol. 171:5872-5881.
    • (1989) J. Bacteriol. , vol.171 , pp. 5872-5881
    • Vara, J.1    Lewandowska-Skarbek, M.2    Wang, Y.-G.3    Donadio, S.4    Hutchinson, C.R.5
  • 39
    • 0025809486 scopus 로고
    • New pUC-derived cloning vectors with different selectable markers and DNA replication origins
    • Vieira, J., and J. Messing. 1991. New pUC-derived cloning vectors with different selectable markers and DNA replication origins. Gene 100:189-194.
    • (1991) Gene , vol.100 , pp. 189-194
    • Vieira, J.1    Messing, J.2
  • 40
    • 0030929313 scopus 로고    scopus 로고
    • A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold
    • Wietzorrek, A., and M. J. Bibb. 1997. A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Mol. Microbiol. 25:1177-1184.
    • (1997) Mol. Microbiol. , vol.25 , pp. 1177-1184
    • Wietzorrek, A.1    Bibb, M.J.2
  • 41
    • 0026597059 scopus 로고
    • Codon usage in the G+C-rich Streptomyces genome
    • Wright, F., and M. J. Bibb. 1992. Codon usage in the G+C-rich Streptomyces genome. Gene 113:55-65.
    • (1992) Gene , vol.113 , pp. 55-65
    • Wright, F.1    Bibb, M.J.2
  • 42
    • 0029937535 scopus 로고    scopus 로고
    • A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: Sequence analysis and complementation of early blocked mutants of the anthracycline pathway
    • Ylihonko, K., J. Hakala, S. Jusilaa, L. Cong, and P. Mäntsälä. 1996. A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early blocked mutants of the anthracycline pathway. Mol. Gen. Genet. 251:113-120.
    • (1996) Mol. Gen. Genet. , vol.251 , pp. 113-120
    • Ylihonko, K.1    Hakala, J.2    Jusilaa, S.3    Cong, L.4    Mäntsälä, P.5


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