Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis

Journal of Bacteriology

Volumn 178, Issue 24, 1996, Pages 7316-7321

  Scotti, Claudio ^a,b   Hutchinson, C Richard ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIBIOTIC AGENT; DAUNORUBICIN; DNA; DOXORUBICIN; EPSILON RHODOMYCINONE; GLYCOSYLTRANSFERASE;

ARTICLE; BIOSYNTHESIS; CODON; DNA SEQUENCE; GENE; GENE CLUSTER; GENE EXPRESSION; MUTANT; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES PEUCETIUS;

EID: 0030451725     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.24.7316-7321.1996     Document Type: Article

References (37)

1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Arcamone, F., G. Cassinelli, G. Fantini, A. Grein, P. Orezzi, C. Pol, and C. Spalla. 1969. 14-Hydroxydaunomycin, a new antitumor antibiotic from Streptomyces peucetius var. caesius. Biotechnol. Bioeng. 11:1109-1110.
3. Bibb, M. J., and S. N. Cohen. 1982. Gene expression in Streptomyces: construction and application of promoter-probe plasmid vectors in Streptomyces lividans. Mol. Gen. Genet. 187:265-277.
4. Bierman, M., R. Logan, K. O'Brien, E. T. Seno, R. Nagaraja Rao, and B. E. Schoner. 1992. Plasmid cloning vectors for the conjugal transfer of DNA from Eschenchia coli to Streptomyces spp. Gene 116:43-49.
5. Cassinelli, G., and P. Orezzi. 1963. Daunomicina: un nuovo antibiotico ad attivita' citoslatica. Isolamento e propieta'. G. Microhiol. 11:167-174.
6. Colombo, A. L., and S. Filippini. Personal communication.
7. D'bost, M., P. Ganter, R. Maral, L. Ninet, S. Pinnert, J. Preud'Homme and G. H. Werner. 1963. Un novel antibiotique a proprietes cytostatiques: la ruhidomycine. C. R. Acad. Sci. Agric. Belg. 257:1813-1815.
8. Dekleva, M. L., J. A. Titus, and W. R. Strohl. 1985. Nutrient effects on anthracycline production by Streptomyces peucetius in a defined medium. Can. J. Microbiol. 31:287-294.
9. Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:387-395.
10. Dickens, M. L., J. Ye, and W. R. Strohl. 1996. Cloning, sequencing and analysis of aklaviketone reductase from Streptomyces sp. strain C5. J. Bacteriol. 178:3384-3388.
11. Filippini, S., M. M. Solinas, U. Breme, M. B. Schluter, D. Gabellini, G. Biamonti, A. L. Colombo, and L. Garofano. 1995 Streptomyces peucetius daunorubicin biosynthesis gene, dnrF: sequence and heterologous expression. Microbiology 141:1007-1016.
12. Gallo, M. A., J. Ward, and C. R. Hutchinson. 1996. Cloning of the dnrL and dnrM genes from the daunorubicin-producing Streptomyces Peucetius. Microbiology 142:269-275.
13. Grimm, A., K. Madduri, A. Ali, and C. R. Hutchinson. 1994. Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase. Gene 151:1-10.
14. Guilfoile, P. G., and C. R. Hutchinson. 1991. A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin. Proc. Natl. Acad. Sci. USA 88:8553-8557.
15. Hernandez, C., C. Olano, C. Mendez, and J. A. Salas. 1993. Characterization of a Streptomyces antibioticus gene cluster encoding a glycosyltransferase involved in oleandomycin inactivation. Gene 134:139-140.
16. Hopwood, D. A., M. J. Bibb, K. F. Chater, T. Kieser, C. J. Bruton, H. M. Kieser, D. Lydiate, C. P. Smith, J. M. Ward, and H. Schrempf. 1985. Genetic manipulation of Streptomyces: a laboratory manual. The John Innes Foundation, Norwich, United Kingdom.
17. Jenkins, G., and E. Cundliffe. 1991. Cloning and characterization of two genes from Streptomyces lividans that confer inducible resistance to lincomycin and macrolide antibiotics. Gene 108:55-62.
18. Katz, L. Personal communication.
19. Lomovskaya, N., S.-K. Hong, S.-U. Kim, L. Fonstein, K. Furuya, and C. R. Hutchinson. 1996. The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production. J. Bacteriol. 178:3238-3235.
20. 1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius. J. Bacteriol. 177:1208-1215.
21. Madduri, K., and C. R. Hutchinson. 1995. Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius. J. Bacteriol, 177:3879-3884.
22. Madduri, K., G. Meurer, M. Goelitz, and C. R. Hutchinson. Unpublished observations.
23. Madduri, K., F. Torti, A. L. Colomb, and C. R. Hutchinson. 1993. Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli. J. Bacteriol. 175:3900-3904.
24. Merson-Davies, L. A., and E. Cundliffe. 1994. Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. Mol. Microbiol. 13:349-355.
25. Muth, G., B. Nussbaumer, W. Wohlleben, and A. Puhler. 1989. A vector system with temperature-sensitive replication for gene disruption and mutational cloning in Streptomyces. Mol. Gen. Genet. 219:341-348.
26. Myers, C. E., E. G. Mimnaugh, G. C. Yeh, and B. K. Sinha. 1988. Biochemical mechanisms of tumor cell kill by the anthracyclines, p. 527-569. In J. W. Lown (ed.), Anthracycline and anthracenedione-based anticancer agents. Elsevier, Amsterdam.
27. Ochsner, U. A., A. Fiechter, and J. Reiser. 1994. Isolation, characterization, and expression in Escherichia coli of Pseudomonus aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis. J. Biol. Chem. 269:19787-19795.
28. 2 locus. J. Bacteriol. 177:1216-1224.
29. Otten, S. L., X. Liu, J. Ferguson, and C. R. Hutchinson. 1995. Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis. J. Bacteriol. 177:6688-6692.
30. Otten, S. L., X. Liu, T. Takatsu, A. Inventi-Solari, U. Breme, A. L. Colombo, and C. R. Hutchinson. Unpublished observations.
31. Otten, S. L., K. J. Stutzman-Engwall, and C. R. Hutchinson. 1990. Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius. J. Bacteriol. 172:3427-3434.
32. Pandey, R. C., M. Toussaint, J. C. McGuire, and M. C. Thomas. 1989. Maggiemycin and anhydromaggiemycin: two novel anthracyclinone antitumor antibiotics. J. Antibiot. 42:1567-1577.
33. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
34. Stutzman-Engwall, K. J., S. L. Otten, and C. R. Hutchinson. 1992. Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubucin in Streptomyces peucetius. J. Bacteriol. 174:144-154.
35. Takahashi, Y., H. Naganawa, T. Takeuchi, H. Umezawa, T. Komiyama, T. Oki, and T. Inui. 1977. The structure of baumycins A1, A2, B1, B2, C1 and C2. J. Antibiot. 30:622-624.
36. Vara, J., M. Lewandowska-Skarbek, Y.-G. Wang, S. Donadio, and C. R. Hutchinson. 1989. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J. Bacteriol. 171:5872-5881.
37. Yanish-Perron, C., J. Vieira and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119.