메뉴 건너뛰기




Volumn 130, Issue 4, 2000, Pages 711-714

Uncoupling protein homologs: Emerging views of physiological function

Author keywords

Metabolic rate; Oxidative phosphorylation; Proton leak

Indexed keywords

UNCOUPLING PROTEIN 1;

EID: 0034103005     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.4.711     Document Type: Review
Times cited : (67)

References (57)
  • 3
    • 0032953969 scopus 로고    scopus 로고
    • Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR
    • Rolfe, D.F.S., Newman, J.M.B., Buckingham, J. A., Clark, M. G. & Brand, M. D. (1999) Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR. Am. J. Physiol. 276: C692-C699.
    • (1999) Am. J. Physiol. , vol.276
    • Rolfe, D.F.S.1    Newman, J.M.B.2    Buckingham, J.A.3    Clark, M.G.4    Brand, M.D.5
  • 5
    • 0032582799 scopus 로고    scopus 로고
    • The mechanism of proton transport by mitochondrial uncoupling proteins
    • Garlid, K. D., Jaburek, M. & Jezek, P. (1998) The mechanism of proton transport by mitochondrial uncoupling proteins. FEBS Lett. 438: 10-14.
    • (1998) FEBS Lett. , vol.438 , pp. 10-14
    • Garlid, K.D.1    Jaburek, M.2    Jezek, P.3
  • 6
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls, D. G. & Locke, R. M. (1984) Thermogenic mechanisms in brown fat. Physiol. Rev. 64: 1-64.
    • (1984) Physiol. Rev. , vol.64 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 7
    • 0025828908 scopus 로고
    • Molecular studies of the uncoupling protein
    • Ricquier, D., Casteilla, L. & Bouillaud, F. (1991) Molecular studies of the uncoupling protein. FASEB J. 5: 2237-2242.
    • (1991) FASEB J. , vol.5 , pp. 2237-2242
    • Ricquier, D.1    Casteilla, L.2    Bouillaud, F.3
  • 8
    • 0028556635 scopus 로고
    • Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat
    • Rolfe, D.F.S., Hulbert, A.J. & Brand, M.D. (1994) Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat. Biochem. Biophys. Acta 1118: 405-416.
    • (1994) Biochem. Biophys. Acta , vol.1118 , pp. 405-416
    • Rolfe, D.F.S.1    Hulbert, A.J.2    Brand, M.D.3
  • 12
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β-adrenergic agents, and leptin
    • Gong, D.-W., He, Y., Karas, M. & Reitman, M. (1997) Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β-adrenergic agents, and leptin. J. Biol. Chem. 272: 24129-24132.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24129-24132
    • Gong, D.-W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 13
    • 0031560941 scopus 로고    scopus 로고
    • UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
    • Vidal-Puig, A., Solanes, G., Grujic, D., Flier, J. S. & Lowell, B. B. (1997) UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem. Biophys. Res. Commun. 235: 79-82.
    • (1997) Biochem. Biophys. Res. Commun. , vol.235 , pp. 79-82
    • Vidal-Puig, A.1    Solanes, G.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 14
    • 0032998265 scopus 로고    scopus 로고
    • UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    • Mao, W., Yu, X. X., Zhong, A. Li, W., Brush, J., Sherwood, S. W., Adams, S. H. & Pan, G. (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 443: 326-330.
    • (1999) FEBS Lett. , vol.443 , pp. 326-330
    • Mao, W.1    Yu, X.X.2    Zhong, A.3    Li, W.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 16
    • 4243215150 scopus 로고    scopus 로고
    • Expression of uncoupling protein homologues, UCP4 and UCP5/(BMCP1): Tissue-specific modulation by nutrition and temperature, and evidence for UCP5 isoforms
    • in press
    • Yu, X. X., Mao, W., Zhong, A., Schow, P., Brush, J., Sherwood, S. W., Adams, S. H. & Pan, G. (2000) Expression of uncoupling protein homologues, UCP4 and UCP5/(BMCP1): tissue-specific modulation by nutrition and temperature, and evidence for UCP5 isoforms. FASEB J. (in press).
    • (2000) FASEB J.
    • Yu, X.X.1    Mao, W.2    Zhong, A.3    Schow, P.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 17
    • 0343720009 scopus 로고    scopus 로고
    • Symposium on Uncoupling Proteins and Obesity. (1999) Int. J. Obesity 23 (suppl. 6): S1-S74.
    • (1999) Int. J. Obesity , vol.23 , Issue.SUPPL. 6
  • 18
    • 0031800882 scopus 로고    scopus 로고
    • Development of infrared imaging to measure thermogenesis in cell culture: Thermogenic effects of uncoupling protein-2, troglitazone, and β-adrenoceptor agonists
    • Paulik, M. A., Buckholz, R. G., Lancaster, M. E., Dallas, W. S., Hull-Ryde, E. A., Weiel, J. E. & Lenhard, J. M. (1998) Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and β-adrenoceptor agonists. Pharm. Res. 15: 944-949.
    • (1998) Pharm. Res. , vol.15 , pp. 944-949
    • Paulik, M.A.1    Buckholz, R.G.2    Lancaster, M.E.3    Dallas, W.S.4    Hull-Ryde, E.A.5    Weiel, J.E.6    Lenhard, J.M.7
  • 22
    • 0030729552 scopus 로고    scopus 로고
    • Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
    • Bouchard, C., Pérusse, L., Chagnon, Y. C., Warden, C. & Ricquier, D. (1997) Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum. Mol. Genet. 6: 1887-1889.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1887-1889
    • Bouchard, C.1    Pérusse, L.2    Chagnon, Y.C.3    Warden, C.4    Ricquier, D.5
  • 23
    • 0033525848 scopus 로고    scopus 로고
    • Genomic organization and regulation by dietary fat of the uncoupling protein 2 and 3 genes
    • Gong, D.-W., He, Y. & Reitman, M. L. (1999) Genomic organization and regulation by dietary fat of the uncoupling protein 2 and 3 genes. Biochem. Biophys. Res. Commun. 256: 27-32.
    • (1999) Biochem. Biophys. Res. Commun. , vol.256 , pp. 27-32
    • Gong, D.-W.1    He, Y.2    Reitman, M.L.3
  • 24
    • 0032797709 scopus 로고    scopus 로고
    • Gene-environment interaction: A significant diet-dependent obesity locus demonstrated in a congenic segment on mouse chromosome 7
    • York, B., Truett, A. A., Monteiro, M. P., Barry, S. J., Warden, C. H., Naggert, J. K., Maddatu, T. P. & West, D. B. (1999) Gene-environment interaction: a significant diet-dependent obesity locus demonstrated in a congenic segment on mouse chromosome 7. Mamm. Genome 10: 457-462.
    • (1999) Mamm. Genome , vol.10 , pp. 457-462
    • York, B.1    Truett, A.A.2    Monteiro, M.P.3    Barry, S.J.4    Warden, C.H.5    Naggert, J.K.6    Maddatu, T.P.7    West, D.B.8
  • 26
    • 0028915135 scopus 로고
    • Use of top-down elasticity analysis to identify sites of thyroid hormone-induced thermogenesis
    • Harper, M.-E. & Brand, M. D. (1995) Use of top-down elasticity analysis to identify sites of thyroid hormone-induced thermogenesis. Proc. Soc. Exp. Biol. Med. 208: 228-237.
    • (1995) Proc. Soc. Exp. Biol. Med. , vol.208 , pp. 228-237
    • Harper, M.-E.1    Brand, M.D.2
  • 27
    • 0033040742 scopus 로고    scopus 로고
    • Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle
    • Lanni, A., Beneduce, L., Lombardi, A., Moreno, M., Boss, O., Muzzin, P., Giacobino, J.-P. & Goglia, F. (1999) Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle. FEBS Lett. 444: 250-254.
    • (1999) FEBS Lett. , vol.444 , pp. 250-254
    • Lanni, A.1    Beneduce, L.2    Lombardi, A.3    Moreno, M.4    Boss, O.5    Muzzin, P.6    Giacobino, J.-P.7    Goglia, F.8
  • 29
    • 0030712088 scopus 로고    scopus 로고
    • Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone
    • Masaki, T., Yoshimatsu, H., Kakuma, T., Hidaka, S., Kurokawa, M. & Sakata, T. (1997) Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone. FEBS Lett. 418: 323-326.
    • (1997) FEBS Lett. , vol.418 , pp. 323-326
    • Masaki, T.1    Yoshimatsu, H.2    Kakuma, T.3    Hidaka, S.4    Kurokawa, M.5    Sakata, T.6
  • 31
    • 0032821425 scopus 로고    scopus 로고
    • Effects of acute leptin administration on the differences in proton leak rate in liver mitochondria from ob/ob mice compared to lean controls
    • Melia, H. P., Andrews, J. F., McBennett, S. M. & Porter, R. K. (1999) Effects of acute leptin administration on the differences in proton leak rate in liver mitochondria from ob/ob mice compared to lean controls. FEBS Lett. 458: 261-264.
    • (1999) FEBS Lett. , vol.458 , pp. 261-264
    • Melia, H.P.1    Andrews, J.F.2    McBennett, S.M.3    Porter, R.K.4
  • 32
    • 0030804677 scopus 로고    scopus 로고
    • Tissue-dependent upregulation of uncoupling proten-2 in response to fasting or cold
    • Boss, O., Samec, S., Dulloo, A., Seydoux, J., Muzzin, P. & Giacobino, J.-P. (1997) Tissue-dependent upregulation of uncoupling proten-2 in response to fasting or cold. FEBS Lett. 412: 111-114.
    • (1997) FEBS Lett. , vol.412 , pp. 111-114
    • Boss, O.1    Samec, S.2    Dulloo, A.3    Seydoux, J.4    Muzzin, P.5    Giacobino, J.-P.6
  • 33
    • 0032481284 scopus 로고    scopus 로고
    • Differential regulation of uncoupling protein-2 and uncoupling protein-3 gene expression in brown adipose tissue during development and cold exposure
    • Carmona, M. C., Valmaseda, A., Brun, S., Viñas, O., Mampel, T., Iglesias, R., Giralt, M. & Villarroya, F. (1998) Differential regulation of uncoupling protein-2 and uncoupling protein-3 gene expression in brown adipose tissue during development and cold exposure. Biochem. Biophys. Res. Commun. 243: 224-228.
    • (1998) Biochem. Biophys. Res. Commun. , vol.243 , pp. 224-228
    • Carmona, M.C.1    Valmaseda, A.2    Brun, S.3    Viñas, O.4    Mampel, T.5    Iglesias, R.6    Giralt, M.7    Villarroya, F.8
  • 36
    • 0032742372 scopus 로고    scopus 로고
    • UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
    • Cadenas, S., Buckingham, J. A., Samec, S., Seydoux, J., Din, N., Dulloo, A. G. & Brand, M. D. (1999) UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Lett. 462: 257-260.
    • (1999) FEBS Lett. , vol.462 , pp. 257-260
    • Cadenas, S.1    Buckingham, J.A.2    Samec, S.3    Seydoux, J.4    Din, N.5    Dulloo, A.G.6    Brand, M.D.7
  • 37
    • 0031832185 scopus 로고    scopus 로고
    • Role of UCP homologues in skeletal muscles and brown adipose tissue: Mediators of thermogenesis or regulators of lipids as fuel substrate?
    • Samec, S., Seydoux, J. & Dulloo, A. G. (1998) Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J. 12: 715-724.
    • (1998) FASEB J. , vol.12 , pp. 715-724
    • Samec, S.1    Seydoux, J.2    Dulloo, A.G.3
  • 38
    • 0031719658 scopus 로고    scopus 로고
    • Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protien homologs. Is there a role for circulating free fatty acids?
    • Samec, S., Seydoux, J. & Dulloo, A. G. (1998) Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protien homologs. Is there a role for circulating free fatty acids? Diabetes 47: 1693-1698.
    • (1998) Diabetes , vol.47 , pp. 1693-1698
    • Samec, S.1    Seydoux, J.2    Dulloo, A.G.3
  • 41
    • 0033087317 scopus 로고    scopus 로고
    • Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans
    • Vidal-Puig, A., Rosenbaum, M., Considine, R. C., Leibel, R. L., Dohm, G. L. & Lowell, B. B. (1999) Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans. Obes. Res. 7: 133-140.
    • (1999) Obes. Res. , vol.7 , pp. 133-140
    • Vidal-Puig, A.1    Rosenbaum, M.2    Considine, R.C.3    Leibel, R.L.4    Dohm, G.L.5    Lowell, B.B.6
  • 42
    • 0032996040 scopus 로고    scopus 로고
    • Mitochondrial proton leak in brown adipose tissue mitochondria of UCP1-deficient mice is GDP insensitive
    • Monemdjou, S., Kozak, L. P. & Harper, M.-E. (1999) Mitochondrial proton leak in brown adipose tissue mitochondria of UCP1-deficient mice is GDP insensitive. Am. J. Physiol. 276 : E1073-E1082.
    • (1999) Am. J. Physiol. , vol.276
    • Monemdjou, S.1    Kozak, L.P.2    Harper, M.-E.3
  • 44
    • 0031972878 scopus 로고    scopus 로고
    • Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
    • Boss, O., Samec, S., Kühne, F., Bijlenga, P., Assimacopoulos-Jeannet, F., Seydoux, J., Giacobino, J.-P. & Muzzin, P. (1998) Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature. J. Biol. Chem. 273: 5-8.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5-8
    • Boss, O.1    Samec, S.2    Kühne, F.3    Bijlenga, P.4    Assimacopoulos-Jeannet, F.5    Seydoux, J.6    Giacobino, J.-P.7    Muzzin, P.8
  • 45
    • 0032973459 scopus 로고    scopus 로고
    • Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous system
    • Hagen, T., Zhang, C.-Y., Slieker, L. J., Chung, W. K., Leibel, R. L. & Lowell, B. B. (1999) Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous system. FEBS Lett. 454: 201-206.
    • (1999) FEBS Lett. , vol.454 , pp. 201-206
    • Hagen, T.1    Zhang, C.-Y.2    Slieker, L.J.3    Chung, W.K.4    Leibel, R.L.5    Lowell, B.B.6
  • 46
    • 0032545711 scopus 로고    scopus 로고
    • Uncoupling protein-3: A muscle-specific gene upregulated by leptin in ob/ob mice
    • Liu, Q., Bai, C., Wang, R., MacDonald, T., Gu, M., Zhang, Q., Morsy, M. A., Caskey, C. T. (1998) Uncoupling protein-3: a muscle-specific gene upregulated by leptin in ob/ob mice. Gene 207: 1-7.
    • (1998) Gene , vol.207 , pp. 1-7
    • Liu, Q.1    Bai, C.2    Wang, R.3    MacDonald, T.4    Gu, M.5    Zhang, Q.6    Morsy, M.A.7    Caskey, C.T.8
  • 48
    • 0030803678 scopus 로고    scopus 로고
    • The human uncoupling protein-3 gene. Genomic structure, chromosomal location, and genetic basis for short and long form transcripts
    • Solanes, G., Vidal-Puig, A., Grujic, D., Flier, J. S. & Lowell, B. B. (1997) The human uncoupling protein-3 gene. Genomic structure, chromosomal location, and genetic basis for short and long form transcripts. J. Biol. Chem. 272: 25433-25436.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25433-25436
    • Solanes, G.1    Vidal-Puig, A.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 51
    • 0032854226 scopus 로고    scopus 로고
    • T3 stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice
    • Jekabsons, M. B., Gregoire, F. M., Schonfeld-Warden, N. A., Warden, C. H. & Horwitz, B. A. (1999) T3 stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice. Am. J. Physiol. 277 : E380-E389.
    • (1999) Am. J. Physiol. , vol.277
    • Jekabsons, M.B.1    Gregoire, F.M.2    Schonfeld-Warden, N.A.3    Warden, C.H.4    Horwitz, B.A.5
  • 52
    • 0033542134 scopus 로고    scopus 로고
    • Up-regulation of uncoupling protein-3 by fatty acid in C2C12 myotubes
    • Hwang, C.-S. & Lane, M. D. (1999) Up-regulation of uncoupling protein-3 by fatty acid in C2C12 myotubes. Biochem. Biophys. Res. Commun. 258: 464-469.
    • (1999) Biochem. Biophys. Res. Commun. , vol.258 , pp. 464-469
    • Hwang, C.-S.1    Lane, M.D.2
  • 53
    • 0031809715 scopus 로고    scopus 로고
    • mRNA expression of the long and short forms of uncoupling protein-3 in obese and lean humans
    • Millet, L., Vidai, H., Larrouy, D., Andreelli, F., Laville, M. & Langin, D. (1998) mRNA expression of the long and short forms of uncoupling protein-3 in obese and lean humans. Diabetologia 41: 829-832.
    • (1998) Diabetologia , vol.41 , pp. 829-832
    • Millet, L.1    Vidai, H.2    Larrouy, D.3    Andreelli, F.4    Laville, M.5    Langin, D.6
  • 54
    • 0033046585 scopus 로고    scopus 로고
    • Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition. A link with insulin resistance
    • Samec, S., Seydoux, J. & Dulloo, A. G. (1999) Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition. A link with insulin resistance. Diabetes 48: 436-441.
    • (1999) Diabetes , vol.48 , pp. 436-441
    • Samec, S.1    Seydoux, J.2    Dulloo, A.G.3
  • 56
    • 0031867963 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein may participate in futile cycling of pyruvate and other monocarboxylates
    • Jezek, P. & Borecky, J. (1998) Mitochondrial uncoupling protein may participate in futile cycling of pyruvate and other monocarboxylates. Am. J. Physiol. 275: C496-C504.
    • (1998) Am. J. Physiol. , vol.275
    • Jezek, P.1    Borecky, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.