메뉴 건너뛰기




Volumn 69, Issue 2, 2010, Pages 232-243

Postgraduate Symposium: The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA

Author keywords

Adipose tissue macrophages; Inflammation; Long chain n 3 PUFA; Obesity induced insulin resistance

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ARACHIDONIC ACID; BLOOD CLOTTING FACTOR 7; C REACTIVE PROTEIN; CYTOKINE; DOCOSAHEXAENOIC ACID; FISH OIL; GLUCOSE; GLUCOSE TRANSPORTER 4; ICOSANOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LINOLEIC ACID; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TYROSINE; TRANSCRIPTION FACTOR;

EID: 77955502543     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665110000042     Document Type: Conference Paper
Times cited : (119)

References (113)
  • 1
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG (2000) Obesity as a medical problem. Nature 404, 635-643.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 7
    • 0029933665 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-α inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase
    • DOI 10.1074/jbc.271.22.13018
    • Peraldi P, Hotamisligil GS, Buurman WA et al. (1996) Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem 271, 13018-13022. (Pubitemid 26175877)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.22 , pp. 13018-13022
    • Peraldi, P.1    Hotamisligil, G.S.2    Buurman, W.A.3    White, M.F.4    Spiegelman, B.M.5
  • 8
    • 33846004396 scopus 로고    scopus 로고
    • Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
    • Lumeng CN, Deyoung SM & Saltiel AR (2007) Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab 292, E166-E174.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292
    • Lumeng, C.N.1    Deyoung, S.M.2    Saltiel, A.R.3
  • 9
    • 0037928877 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids, inflammation and obesity-related disease
    • DOI 10.1079/PNS2003252
    • Browning LM (2003) n-3 Polyunsaturated fatty acids, inflammation and obesity-related disease. Proc Nutr Soc 62, 447-453. (Pubitemid 36841620)
    • (2003) Proceedings of the Nutrition Society , vol.62 , Issue.2 , pp. 447-453
    • Browning, L.M.1
  • 10
    • 0037453031 scopus 로고    scopus 로고
    • Obesity, insulin resistance, diabetes, and cardiovascular risk in children: An American heart association scientific statement from the atherosclerosis, hypertension, and obesity in the young committee (council on cardiovascular disease in the young) and the diabetes committee (council on nutrition, physical activity, and metabolism)
    • DOI 10.1161/01.CIR.0000060923.07573.F2
    • Steinberger J & Daniels SR (2003) Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation 107, 1448-1453. (Pubitemid 36350747)
    • (2003) Circulation , vol.107 , Issue.10 , pp. 1448-1453
    • Steinberger, J.1    Daniels, S.R.2
  • 11
    • 0028917432 scopus 로고
    • Weight gain as a risk factor for clinical diabetes mellitus in women
    • Colditz GA, Willett WC, Rotnitzky A et al. (1995) Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 122, 481-486.
    • (1995) Ann. Intern. Med. , vol.122 , pp. 481-486
    • Colditz, G.A.1    Willett, W.C.2    Rotnitzky, A.3
  • 12
    • 0027966932 scopus 로고
    • Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men
    • Chan JM, Rimm EB, Colditz GA et al. (1994) Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 17, 961-969.
    • (1994) Diabetes Care , vol.17 , pp. 961-969
    • Chan, J.M.1    Rimm, E.B.2    Colditz, G.A.3
  • 14
    • 0031735314 scopus 로고    scopus 로고
    • Type 2 diabetes - Who is conducting the orchestra?
    • DOI 10.1038/3018
    • Kahn BB & Rossetti L (1998) Type 2 diabetes - who is conducting the orchestra? Nat Genet 20, 223-225. (Pubitemid 28507661)
    • (1998) Nature Genetics , vol.20 , Issue.3 , pp. 223-225
    • Kahn, B.B.1    Rossetti, L.2
  • 15
    • 77957300749 scopus 로고    scopus 로고
    • International Diabetes Federation
    • International Diabetes Federation (2009) Diabetes atlas: Diabetic complications. http://da3.diabetesatlas.org/index711b.html
    • (2009) Diabetes Atlas: Diabetic Complications
  • 16
    • 13244287802 scopus 로고    scopus 로고
    • Post-prandial hyperglycaemia and prevention of cardiovascular disease
    • Davies MJ (2005) Post-prandial hyperglycaemia and prevention of cardiovascular disease. Diabet Med 22, Suppl. 1, 6-9. (Pubitemid 40188300)
    • (2005) Diabetic Medicine, Supplement , vol.22 , Issue.1 , pp. 6-9
    • Davies, M.J.1
  • 17
    • 0021904906 scopus 로고
    • The molecular mechanism of insulin action
    • Kahn CR (1985) The molecular mechanism of insulin action. Annu Rev Med 36, 429-451.
    • (1985) Annu. Rev. Med. , vol.36 , pp. 429-451
    • Kahn, C.R.1
  • 18
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM (1995) Pathophysiology of insulin resistance in human disease. Physiol Rev 75, 473-486.
    • (1995) Physiol. Rev. , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 19
    • 0031171216 scopus 로고    scopus 로고
    • The IRS-signalling system during insulin and cytokine action
    • Yenush L & White MF (1997) The IRS-signalling system during insulin and cytokine action. Bioessays 19, 491-500. (Pubitemid 27299497)
    • (1997) BioEssays , vol.19 , Issue.6 , pp. 491-500
    • Yenush, L.1    White, M.F.2
  • 20
    • 0031913246 scopus 로고    scopus 로고
    • Mechanism of activation and function of protein kinase B
    • DOI 10.1016/S0959-437X(98)80062-2
    • Alessi DR & Cohen P (1998) Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8, 55-62. (Pubitemid 28122141)
    • (1998) Current Opinion in Genetics and Development , vol.8 , Issue.1 , pp. 55-62
    • Alessi, D.R.1    Cohen, P.2
  • 21
    • 0036434431 scopus 로고    scopus 로고
    • Insulin regulation of glucose uptake: A complex interplay of intracellular signalling pathways
    • Khan AH & Pessin JE (2002) Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 45, 1475-1483.
    • (2002) Diabetologia , vol.45 , pp. 1475-1483
    • Khan, A.H.1    Pessin, J.E.2
  • 22
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross DA, Alessi DR, Cohen P et al. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789. (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 26
    • 0034708832 scopus 로고    scopus 로고
    • 307
    • DOI 10.1074/jbc.275.12.9047
    • Aguirre V, Uchida T, Yenush L et al. (2000) The c-Jun. NH (2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser (307). J Biol Chem 275, 9047-9054. (Pubitemid 30180265)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 27
    • 0037059330 scopus 로고    scopus 로고
    • 307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • DOI 10.1074/jbc.M101521200
    • Aguirre V, Werner ED, Giraud J et al. (2002) Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277, 1531-1537. (Pubitemid 34968910)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.2 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 30
    • 0033598749 scopus 로고    scopus 로고
    • Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
    • Shimomura I, Bashmakov Y, Ikemoto S et al. (1999) Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci USA 96, 13656-13661.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13656-13661
    • Shimomura, I.1    Bashmakov, Y.2    Ikemoto, S.3
  • 31
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis- related genes
    • DOI 10.1073/pnas.96.22.12737
    • Foretz M, Guichard C, Ferre P et al. (1999) Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci USA 96, 12737-12742. (Pubitemid 29513572)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.22 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3    Foufelle, F.4
  • 32
    • 0032759047 scopus 로고    scopus 로고
    • Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling
    • Kops GJ & Burgering BM (1999) Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J Mol Med 77, 656-665.
    • (1999) J. Mol. Med. , vol.77 , pp. 656-665
    • Kops, G.J.1    Burgering, B.M.2
  • 34
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • DOI 10.1079/BJN20041213
    • Trayhurn P & Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92, 347-355. (Pubitemid 40277057)
    • (2004) British Journal of Nutrition , vol.92 , Issue.3 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 35
    • 0031000588 scopus 로고    scopus 로고
    • Elevated expression of transforming growth factor-β in adipose tissue from obese mice
    • Samad F, Yamamoto K, Pandey M et al. (1997) Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med 3, 37-48. (Pubitemid 27142523)
    • (1997) Molecular Medicine , vol.3 , Issue.1 , pp. 37-48
    • Samad, F.1    Yamamoto, K.2    Pandey, M.3    Loskutoff, D.J.4
  • 36
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS & Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 37
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA & Greenberg AS (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83, 847-850.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 38
    • 0034770292 scopus 로고    scopus 로고
    • Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
    • DOI 10.1038/nm1001-1138
    • Perreault M & Marette A (2001) Targeted disruption of inducible nitric oxide synthase protects against obesitylinked insulin resistance in muscle. Nat Med 7, 1138-1143. (Pubitemid 33010023)
    • (2001) Nature Medicine , vol.7 , Issue.10 , pp. 1138-1143
    • Perreault, M.1    Marette, A.2
  • 39
    • 0033537013 scopus 로고    scopus 로고
    • Elevated C-reactive protein levels in overweight and obese adults
    • Visser M, Bouter LM, McQuillan GM et al. (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA 282, 2131-2135.
    • (1999) JAMA , vol.282 , pp. 2131-2135
    • Visser, M.1    Bouter, L.M.2    McQuillan, G.M.3
  • 41
    • 0030050952 scopus 로고    scopus 로고
    • Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-α and lipopolysaccharide
    • Samad F, Yamamoto K & Loskutoff DJ (1996) Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide. J Clin Invest 97, 37-46. (Pubitemid 26021692)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.1 , pp. 37-46
    • Samad, F.1    Yamamoto, K.2    Loskutoff, D.J.3
  • 46
    • 55849130382 scopus 로고    scopus 로고
    • Macrophage infiltration into adipose tissue: Initiation, propagation and remodeling
    • Surmi BK & Hasty AH (2008) Macrophage infiltration into adipose tissue: initiation, propagation and remodeling. Future Lipidol 3, 545-556.
    • (2008) Future Lipidol , vol.3 , pp. 545-556
    • Surmi, B.K.1    Hasty, A.H.2
  • 48
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • DOI 10.1152/ajpendo.00435.2007
    • Ye J, Gao Z, Yin J et al. (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293, E1118-E1128. (Pubitemid 47535846)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.293 , Issue.4
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 49
    • 24944489186 scopus 로고    scopus 로고
    • Modulation of angiogenesis during adipose tissue development in murine models of obesity
    • DOI 10.1210/en.2005-0532
    • Voros G, Maquoi E, Demeulemeester D et al. (2005) Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 146, 4545-4554. (Pubitemid 41324053)
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4545-4554
    • Voros, G.1    Maquoi, E.2    Demeulemeester, D.3    Clerx, N.4    Collen, D.5    Lijnen, H.R.6
  • 50
    • 52649126788 scopus 로고    scopus 로고
    • Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity
    • Pang C, Gao Z, Yin J et al. (2008) Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab 295, E313-E322.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295
    • Pang, C.1    Gao, Z.2    Yin, J.3
  • 52
    • 40849116790 scopus 로고    scopus 로고
    • Induction of renoprotective gene expression by hypoxia-inducible transcription factor-1α ameliorates renal damage
    • DOI 10.1016/j.mehy.2007.08.029, PII S0306987707005865
    • Wang W & Zhang J (2008) Induction of renoprotective gene expression by hypoxia-inducible transcription factor-1alpha ameliorates renal damage. Med Hypotheses 70, 948-950. (Pubitemid 351400708)
    • (2008) Medical Hypotheses , vol.70 , Issue.5 , pp. 948-950
    • Wang, W.1    Zhang, J.2
  • 54
    • 17844393870 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT) : Implication of macrophages resident in the AT
    • Bruun JM, Lihn AS, Pedersen SB et al. (2005) Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT) : implication of macrophages resident in the AT. J Clin Endocrinol Metab 90, 2282-2289.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 2282-2289
    • Bruun, J.M.1    Lihn, A.S.2    Pedersen, S.B.3
  • 55
    • 11244302456 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects
    • DOI 10.1038/sj.ijo.0802839
    • Christiansen T, Richelsen B & Bruun JM (2005) Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes (Lond) 29, 146-150. (Pubitemid 40065478)
    • (2005) International Journal of Obesity , vol.29 , Issue.1 , pp. 146-150
    • Christiansen, T.1    Richelsen, B.2    Bruun, J.M.3
  • 57
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • DOI 10.1038/nri957
    • Savill J, Dransfield I, Gregory C et al. (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2, 965-975. (Pubitemid 37323217)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 58
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL & Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117, 175-184.
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 59
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • DOI 10.1038/nri1733
    • Gordon S & Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5, 953-964. (Pubitemid 41746764)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.12 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 60
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • DOI 10.1016/j.it.2004.09.015, PII S1471490604002959
    • Mantovani A, Sica A, Sozzani S et al. (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25, 677-686. (Pubitemid 39457982)
    • (2004) Trends in Immunology , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 61
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH et al. (2007) Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447, 1116-1120.
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3
  • 63
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW et al. (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389, 610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3
  • 65
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects
    • DOI 10.1074/jbc.M301977200
    • Rotter V, Nagaev I & Smith U (2003) Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278, 45777-45784. (Pubitemid 37432722)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.46 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 66
  • 67
    • 33644782904 scopus 로고    scopus 로고
    • Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance
    • Shi H, Cave B, Inouye K et al. (2006) Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes 55, 699-707. (Pubitemid 43343226)
    • (2006) Diabetes , vol.55 , Issue.3 , pp. 699-707
    • Shi, H.1    Cave, B.2    Inouye, K.3    Bjorbaek, C.4    Flier, J.S.5
  • 68
    • 0344686538 scopus 로고    scopus 로고
    • MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632
    • DOI 10.1007/s00125-003-1223-4
    • Gual P, Gremeaux T, Gonzalez T et al. (2003) MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia 46, 1532-1542. (Pubitemid 37518574)
    • (2003) Diabetologia , vol.46 , Issue.11 , pp. 1532-1542
    • Gual, P.1    Gremeaux, T.2    Gonzalez, T.3    Le Marchand-Brustel, Y.4    Tanti, J.-F.5
  • 69
    • 33845873659 scopus 로고    scopus 로고
    • Interleukin-1β-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
    • DOI 10.1210/en.2006-0692
    • Jager J, Gremeaux T, Cormont M et al. (2007) Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 148, 241-251. (Pubitemid 46021456)
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 241-251
    • Jager, J.1    Gremeaux, T.2    Cormont, M.3    Le Marchand-Brustel, Y.4    Tanti, J.-F.5
  • 70
    • 0031755148 scopus 로고    scopus 로고
    • Nuclear factor kappa B: A pivotal role in the systemic inflammatory response syndrome and new target for therapy
    • Christman JW, Lancaster LH & Blackwell TS (1998) Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med 24, 1131-1138.
    • (1998) Intensive Care Med. , vol.24 , pp. 1131-1138
    • Christman, J.W.1    Lancaster, L.H.2    Blackwell, T.S.3
  • 71
    • 0032900439 scopus 로고    scopus 로고
    • New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases
    • Chen F, Castranova V, Shi X et al. (1999) New insights into the role of nuclear factor-kappa B, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45, 7-17. (Pubitemid 29036378)
    • (1999) Clinical Chemistry , vol.45 , Issue.1 , pp. 7-17
    • Chen, F.1    Castranova, V.2    Shi, X.3    Demers, L.M.4
  • 73
    • 0028303945 scopus 로고
    • Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis: A 12-month, double-blind, controlled study
    • DOI 10.1002/art.1780370608
    • Geusens P, Wouters C, Nijs J et al. (1994) Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study. Arthritis Rheum 37, 824-829. (Pubitemid 24184532)
    • (1994) Arthritis and Rheumatism , vol.37 , Issue.6 , pp. 824-829
    • Geusens, P.1    Wouters, C.2    Nijs, J.3    Jiang, Y.4    Dequeker, J.5
  • 74
    • 0030999963 scopus 로고    scopus 로고
    • Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production
    • Broughton KS, Johnson CS, Pace BK et al. (1997) Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production. Am J Clin Nutr 65, 1011-1017.
    • (1997) Am. J. Clin. Nutr. , vol.65 , pp. 1011-1017
    • Broughton, K.S.1    Johnson, C.S.2    Pace, B.K.3
  • 77
    • 34247638400 scopus 로고    scopus 로고
    • Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease
    • Sijben JW & Calder PC (2007) Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Proc Nutr Soc 66, 237-259.
    • (2007) Proc. Nutr. Soc. , vol.66 , pp. 237-259
    • Sijben, J.W.1    Calder, P.C.2
  • 78
    • 0021965878 scopus 로고
    • Paleolithic nutrition. A consideration of its nature and current implications
    • Eaton SB & Konner M (1985) Paleolithic nutrition. A consideration of its nature and current implications. N Engl J Med 312, 283-289. (Pubitemid 15199367)
    • (1985) New England Journal of Medicine , vol.312 , Issue.5 , pp. 283-289
    • Eaton, S.B.1    Konner, M.2
  • 80
    • 33746830525 scopus 로고    scopus 로고
    • N-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
    • Calder PC (2006) n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83, 1505S-1519S. (Pubitemid 44713092)
    • (2006) American Journal of Clinical Nutrition , vol.83 , Issue.6
    • Calder, P.C.1
  • 82
    • 0025164256 scopus 로고
    • Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases
    • Lewis RA, Austen KF & Soberman RJ (1990) Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 323, 645-655.
    • (1990) N. Engl. J. Med. , vol.323 , pp. 645-655
    • Lewis, R.A.1    Austen, K.F.2    Soberman, R.J.3
  • 83
    • 0034943516 scopus 로고    scopus 로고
    • Mixed messages: Modulation of inflammation and immune responses by prostaglandins and thromboxanes
    • Tilley SL, Coffman TM & Koller BH (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108, 15-23.
    • (2001) J. Clin. Invest. , vol.108 , pp. 15-23
    • Tilley, S.L.1    Coffman, T.M.2    Koller, B.H.3
  • 84
    • 0034221273 scopus 로고    scopus 로고
    • Human requirement for N-3 polyunsaturated fatty acids
    • Simopoulos AP (2000) Human requirement for N-3 polyunsaturated fatty acids. Poult Sci 79, 961-970.
    • (2000) Poult Sci. , vol.79 , pp. 961-970
    • Simopoulos, A.P.1
  • 85
    • 0036213141 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acids and regulation of gene transcription
    • DOI 10.1097/00041433-200204000-00007
    • Jump DB (2002) Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol 13, 155-164. (Pubitemid 34280767)
    • (2002) Current Opinion in Lipidology , vol.13 , Issue.2 , pp. 155-164
    • Jump, D.B.1
  • 86
    • 39749122734 scopus 로고    scopus 로고
    • The opposing effects of n-3 and n-6 fatty acids
    • Schmitz G & Ecker J (2008) The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 47, 147-155.
    • (2008) Prog. Lipid Res. , vol.47 , pp. 147-155
    • Schmitz, G.1    Ecker, J.2
  • 88
    • 0032814457 scopus 로고    scopus 로고
    • Regulation of gene expression by dietary fat
    • DOI 10.1146/annurev.nutr.19.1.63
    • Jump DB & Clarke SD (1999) Regulation of gene expression by dietary fat. Annu Rev Nutr 19, 63-90. (Pubitemid 29380597)
    • (1999) Annual Review of Nutrition , vol.19 , pp. 63-90
    • Jump, D.B.1    Clarke, S.D.2
  • 89
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    • DOI 10.1038/34184
    • Jiang C, Ting AT & Seed B (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82-86. (Pubitemid 28079219)
    • (1998) Nature , vol.391 , Issue.6662 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 90
    • 0032484123 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappa B signaling, and reduces inflammatory cytokine production in aging
    • Poynter ME & Daynes RA (1998) Peroxisome proliferatoractivated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappa B signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 273, 32833-32841.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32833-32841
    • Poynter, M.E.1    Daynes, R.A.2
  • 91
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • DOI 10.1038/34178
    • Ricote M, Li AC, Willson TM et al. (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391, 79-82. (Pubitemid 28079218)
    • (1998) Nature , vol.391 , Issue.6662 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 93
    • 0032587328 scopus 로고    scopus 로고
    • PPARγ activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARγ as a potential mediator in vascular disease
    • Marx N, Bourcier T, Sukhova GK et al. (1999) PPAR-gamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPAR-gamma as a potential mediator in vascular disease. Arterioscler Thromb Vasc Biol 19, 546-551. (Pubitemid 29135154)
    • (1999) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.19 , Issue.3 , pp. 546-551
    • Marx, N.1    Bourcier, T.2    Sukhova, G.K.3    Libby, P.4    Plutzky, J.5
  • 94
    • 0034730794 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes
    • Takano H, Nagai T, Asakawa M et al. (2000) Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes. Circ Res 87, 596-602.
    • (2000) Circ. Res. , vol.87 , pp. 596-602
    • Takano, H.1    Nagai, T.2    Asakawa, M.3
  • 97
    • 18144452275 scopus 로고    scopus 로고
    • Les peroxisome proliferator-activated receptors: Des récepteurs nucléaires au carrefour entre métabolisme lipidique et inflammation
    • Chinetti G, Fruchart JC & Staels B (2000) Peroxisome proliferator-activated receptors (PPARs) : nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 49, 497-505. (Pubitemid 32294402)
    • (2001) Sang Thrombose Vaisseaux , vol.13 , Issue.2 , pp. 82-88
    • Bocher, V.1    Chinetti, G.2    Fruchart, J.-C.3    Staels, B.4
  • 98
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • DOI 10.1677/joe.0.1690453
    • Delerive P, Fruchart JC & Staels B (2001) Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 169, 453-459. (Pubitemid 32536978)
    • (2001) Journal of Endocrinology , vol.169 , Issue.3 , pp. 453-459
    • Delerive, P.1    Fruchart, J.-C.2    Staels, B.3
  • 99
    • 33847796933 scopus 로고    scopus 로고
    • Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid
    • Weldon SM, Mullen AC, Loscher CE et al. (2007) Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. J Nutr Biochem 18, 250-258.
    • (2007) J. Nutr. Biochem. , vol.18 , pp. 250-258
    • Weldon, S.M.1    Mullen, A.C.2    Loscher, C.E.3
  • 100
    • 33746772121 scopus 로고    scopus 로고
    • Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids
    • DOI 10.1007/s00125-006-0300-x
    • Todoric J, Loffler M, Huber J et al. (2006) Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids. Diabetologia 49, 2109-2119. (Pubitemid 44168479)
    • (2006) Diabetologia , vol.49 , Issue.9 , pp. 2109-2119
    • Todoric, J.1    Loffler, M.2    Huber, J.3    Bilban, M.4    Reimers, M.5    Kadl, A.6    Zeyda, M.7    Waldhausl, W.8    Stulnig, T.M.9
  • 101
    • 0035907302 scopus 로고    scopus 로고
    • Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4
    • DOI 10.1074/jbc.M011695200
    • Lee JY, Sohn KH, Rhee SH et al. (2001) Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 276, 16683-16689. (Pubitemid 37411459)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.20 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 103
    • 0038143617 scopus 로고    scopus 로고
    • Differential modulation of Toll-like receptors by fatty acids: Preferential inhibition by n-3 polyunsaturated fatty acids
    • DOI 10.1194/jlr.M200361-JLR200
    • Lee JY, Plakidas A, Lee WH et al. (2003) Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res 44, 479-486. (Pubitemid 37279695)
    • (2003) Journal of Lipid Research , vol.44 , Issue.3 , pp. 479-486
    • Lee, J.Y.1    Plakidas, A.2    Lee, W.H.3    Heikkinen, A.4    Chanmugam, P.5    Bray, G.6    Hwang, D.H.7
  • 104
    • 58149476609 scopus 로고    scopus 로고
    • Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice
    • Coenen KR, Gruen ML, Lee-Young RS et al. (2009) Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia 52, 318-328.
    • (2009) Diabetologia , vol.52 , pp. 318-328
    • Coenen, K.R.1    Gruen, M.L.2    Lee-Young, R.S.3
  • 105
    • 0019293677 scopus 로고
    • Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974
    • Kromann N & Green A (1980) Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974. Acta Med Scand 208, 401-406. (Pubitemid 11162992)
    • (1980) Acta Medica Scandinavica , vol.208 , Issue.5 , pp. 401-406
    • Kromann, N.1    Green, A.2
  • 106
    • 0027988668 scopus 로고
    • Lower prevalence of impaired glucose tolerance and diabetes associated with daily seal oil or salmon consumption among Alaska Natives
    • Adler AI, Boyko EJ, Schraer CD et al. (1994) Lower prevalence of impaired glucose tolerance and diabetes associated with daily seal oil or salmon consumption among Alaska Natives. Diabetes Care 17, 1498-1501.
    • (1994) Diabetes Care , vol.17 , pp. 1498-1501
    • Adler, A.I.1    Boyko, E.J.2    Schraer, C.D.3
  • 107
    • 0033201868 scopus 로고    scopus 로고
    • Low fasting insulin levels in Eskimos compared to American Indians: Are Eskimos less insulin resistant?
    • Schraer CD, Risica PM, Ebbesson SO et al. (1999) Low fasting insulin levels in Eskimos compared to American Indians: are Eskimos less insulin resistant? Int J Circumpolar Health 58, 272-280.
    • (1999) Int. J. Circumpolar Health , vol.58 , pp. 272-280
    • Schraer, C.D.1    Risica, P.M.2    Ebbesson, S.O.3
  • 108
    • 0037446755 scopus 로고    scopus 로고
    • Fish and long-chain ω-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women
    • DOI 10.1161/01.CIR.0000062644.42133.5F
    • Hu FB, Cho E, Rexrode KM et al. (2003) Fish and longchain omega-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women. Circulation 107, 1852-1857. (Pubitemid 36444124)
    • (2003) Circulation , vol.107 , Issue.14 , pp. 1852-1857
    • Hu, F.B.1    Cho, E.2    Rexrode, K.M.3    Albert, C.M.4    Manson, J.E.5
  • 109
    • 0035463894 scopus 로고    scopus 로고
    • Dietary fat and incidence of type 2 diabetes in older Iowa women
    • Meyer KA, Kushi LH, Jacobs DR Jr et al. (2001) Dietary fat and incidence of type 2 diabetes in older Iowa women. Diabetes Care 24, 1528-1535. (Pubitemid 33716444)
    • (2001) Diabetes Care , vol.24 , Issue.9 , pp. 1528-1535
    • Meyer, K.A.1    Kushi, L.H.2    Jacobs Jr., D.R.3    Folsom, A.R.4
  • 111
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • Storlien LH, Jenkins AB, Chisholm DJ et al. (1991) Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 40, 280-289.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3
  • 113
    • 2442569854 scopus 로고    scopus 로고
    • Effects of fish oil on hypertension, plasma lipids, and tumor necrosis factor-alpha in rats with sucroseinduced metabolic syndrome
    • Aguilera AA, Diaz GH, Barcelata ML et al. (2004) Effects of fish oil on hypertension, plasma lipids, and tumor necrosis factor-alpha in rats with sucroseinduced metabolic syndrome. J Nutr Biochem 15, 350-357.
    • (2004) J. Nutr. Biochem. , vol.15 , pp. 350-357
    • Aguilera, A.A.1    Diaz, G.H.2    Barcelata, M.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.