Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease

New England Journal of Medicine

Volumn 334, Issue 24, 1996, Pages 1557-1560

  Belluzzi, Andrea ^a,c   Brignola, Corrado ^a   Campieri, Massimo ^a   Pera, Angelo ^b   Boschi, Stefano ^a   Miglioli, Mario ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

^c NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FISH OIL; OMEGA 3 FATTY ACID;

ADULT; ADVERSE DRUG REACTION; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; DIARRHEA; DIGESTIVE SYSTEM FUNCTION DISORDER; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENTERIC COATED TABLET; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PRIORITY JOURNAL; RELAPSE; REMISSION;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; CAPSULES; CROHN DISEASE; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; FEMALE; FISH OILS; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RECURRENCE; TABLETS, ENTERIC-COATED; TREATMENT OUTCOME;

EID: 0029992279     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199606133342401     Document Type: Article

References (31)

1. Wright JP, Young GO, Tigler-Wybrandi N. Predictors of acute relapse of Crohn's disease: a laboratory and clinical study. Dig Dis Sci 1987;32:164-70.
2. Brignola C, Campieri M, Bazzocchi G, Farruggia P, Tragnone A, Lanfranchi GA. A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease. Gastroenterology 1986;91:1490-4.
3. Gendre JP, Mary JY, Florent C, et al. Oral mesalamine (Pentasa) as maintenance treatment in Crohn's disease: a multicenter placebo-controlled study. Gastroenterology 1993; 104:435-9.
4. Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 1992;33:922-8.
5. Stenson WF, Cort D, Rodgers J, et al. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med 1992;116:609-14.
6. Asian A, Triadafilopoulos G. Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Am J Gastroenterol 1992;87:432-7.
7. Matè J, Castaños R, Garcia-Samaniego J, Pajares JM. Does dietary fish oil maintain the remission of Crohn's disease (CD): a study case control. Gastroenterology 1991;100:Suppl:A228. abstract.
8. Lorenz R, Weber PC, Szimnau P, Heldwein W, Strasser T, Loeschke K. Supplementation with n-3 fatty acids from fish oil in chronic inflammatory bowel disease - a randomized, placebo-controlled, double-blind cross-over trial. J Intern Med Suppl 1989:225:225-32.
9. Appel LJ, Miller ER III, Seidler AJ, Whelton PK. Does supplementation of diet with "fish oil" reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 1993; 153:1429-38.
10. O'Connor GT, Malenka DJ, Olmstead EM, Johnson PS, Hennekens CH. A meta-analysis of randomized trials of fish oil in prevention of restenosis following coronary angioplasty. Am J Prev Med 1992;8:186-92.
11. Donnelly SM, Ali M A, Churchill DN. Effect of n-3 fatty acids from fish oil on hemostasis, blood pressure, and lipid profile of dialysis patients. J Am Soc Nephrol 1992;2:1634-9.
12. Belluzzi A, Brignola C, Campieri M, et al. Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. Dig Dis Sci 1994;39:2589-94.
13. Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn's disease activity index: National Cooperative Crohn's Disease Study. Gastroenterology 1976;70:439-44.
14. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
15. Hosmer DW Jr, Lemeshow S. Applied logistic regression. New York: John Wiley, 1989.
16. Lee TH, Hoover RL, Williams JD, et al. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 1985;312:1217-24.
17. Rampton DS, Collins CE. Thromboxanes in inflammatory bowel disease - pathogenic and therapeutic implications. Aliment Pharmacol Ther 1993;7: 357-67.
18. Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-l and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265-71.
19. Fisher M, Upchurch KS, Levine PH, et al. Effects of dietary fish oil supplementation on polymorphonuclear leucocyte inflammatory potential. Inflammation 1986;10:387-92.
20. Wakefield AJ, Sawyerr AM, Dhillon AP, et al. Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet 1989;2:1057-62.
21. Webberley MJ, Hart MT, Melikian V. Thromboembolism in inflammatory bowel disease: role of platelets. Gut 1993;34:247-51.
22. MacIntyre DE, Hoover RL, Smith M, et al. Inhibition of platelet function by cis-unsaturated fatty acids. Blood 1984;63:848-57.
23. Jaschonek K, Clemens MR, Scheurlen M. Decreased responsiveness of platelets to a stable prostacyclin analogue in patients with Crohn's disease: reversal by n-3 polyunsaturated fatty acids. Thromb Res 1991;63:667-72.
24. Vanderhoof JA, Park JHY, Herrington MK, Adrian TE. Effects of dietary menhaden oil mucosal adaptation after small bowel resection in rats. Gastroenterology 1994;106:94-9.
25. Brignola C, Iannone P, Belloli C, et al. Prediction of relapse in patients with Crohn's disease in remission: a simplified index using laboratory tests, enhanced by clinical characteristics. Eur J Gastroenterol Hepatol 1994;6:955-61.
26. el Boustani S, Colette C, Monnier L, Descomps B, de Paulet AC, Mendy F. Enterai absorption in man of eicosapentaenoic acid in different chemical forms. Lipids 1987;22:711-4.
27. Lawson LD, Hughes BG. Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters. Biochem Biophys Res Commun 1988;152:328-35.
28. International Mesalazine Study Group. Coated oral 5-aminosalicylic acid versus placebo in maintaining remission of inactive Crohn's disease. Aliment Pharmacol Ther 1990;4:55-64.
29. Prantera C, Pallone F, Brunetti G, Cottone M, Miglioli M, Italian IBD Study Group. Oral 5-aminosalicylic acid (Asacol) in the maintenance treatment of Crohn's disease. Gaslroenterology 1992;103:363-8.
30. Brignola C, Iannone P, Pasquali S, et al. Placebo-controlled trial of oral 5-ASA in relapse prevention of Crohn's disease. Dig Dis Sci 1992;37:29-32.
31. Messori A, Brignola C, Trallori G, et al. Effectiveness of 5-aminosalicylic acid for maintaining remission in patients with Crohn's disease: a meta-analysis. Am J Gastroenterol 1994;89:692-8.