THG113: A novel selective FP antagonist that delays preterm labor

Seminars in Perinatology

Volumn 26, Issue 6, 2002, Pages 389-397

  Peri, Krishna G ^b   Quiniou, Christiane ^a   Xin, Hou ^a   Abran, Daniel ^b   Varma, Daya R ^c   Lubell, William D ^d   Chemtob, Sylvain ^a,c  

^a UNIVERSITY OF MONTREAL   (Canada)

^b Theratechnologies Inc   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANGIOTENSIN; ENDOTHELIN; ENDOTOXIN; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITIDE; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTANOID; PROSTANOID RECEPTOR; THG 113; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIRTH WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG SELECTIVITY; EMBRYO; FEMALE; FETUS; FORCE; HUMAN; HUMAN CELL; HYDROLYSIS; LABOR; MICROVASCULATURE; MOUSE; MYOMETRIUM; NEWBORN; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; SURVIVAL RATE; SWINE; TOCOLYSIS;

EID: 12244276760     PISSN: 01460005     EISSN: None     Source Type: Journal    
DOI: 10.1053/sper.2002.37307     Document Type: Conference Paper

References (40)

1. Wright DH, Abran D, Chemtob S, et al: Prostanoid receptors: ontogeny and implications in vascular physiology. Am J Physiol 281:R1343-R1360, 2001
2. Crankshaw DJ, Dyal R: Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contractility of the human lower uterine segment in vitro. Can J Physiol Pharmacol 72:870-874, 1994
3. Olson DM, Mijovic JE, Sadowsky DW: Control of human parturition. Semin Perinatol 19:52-63, 1995
4. Ma XH, Wu WX, Nathanielsz PW: Differential regulation of prostaglandin EP and FP receptors in pregnant sheep myometrium and endometrium during spontaneous term labor. Biol Reprod 61:1281-1286, 1999
5. 2α in amniotic fluid during pregnancy and labour. Prostaglandins 4:523-533, 1973
6. Dray F, Frydman R: Primary prostaglandins in amniotic fluid in pregnancy and spontaneous labor. Am J Obstet Gynecol 126:13-19, 1976
7. Luckas M, Bricker L: Intravenous prostaglandin for induction of labour. Cochrane Database of systematic reviews, Issue 4, 2001
8. Cook JL, Zaragoza DB, Sung DH, et al: Expression of myometrial activation and stimulation genes in a mouse model of preterm labor: Myometrial activation, stimulation, and preterm labor. Endocrinology 141:1718-1728, 2000
9. Fuchs AR, Fuchs F, Husslein P, et al: Oxytocin receptors and human parturition: A dual role for oxytocin in the initiation of labor. Science 215:1396-1398, 1982
10. Senior J, Marshall K, Sangha R, et al: In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Br J Pharmacol 108:501-506, 1993
11. Brodt-Eppley J, Myatt L: Prostaglandin receptors in lower segment myometrium during gestation and labor. Obstet Gynecol 93:89-93, 1999
12. 2α secretion during luteolysis in swine, in Ivell R, Russell J (eds): Oxytocin. NY, Plenum Press, 1995, pp 421-433
13. Mirando MA, Prince BC, Tysseling KA, et al: proposed role for oxytocin in regulation of endometrial prostaglandin F2 alpha secretion during luteolysis in swine. Adv Exp Med Biol 395:421-433, 1995
14. Niebyl JR, Blake DA, White RD, et al: The inhibition of premature labor with indomethacin. Am J Obstet Gynecol 136:1014-1019, 1980
15. Morales WJ, Angel JL, O'Brien WF, et al: Use of ampicillin and corticosteroids in premature rupture of membranes: a randomized study. Obstet Gynecol 73:721-726, 1989
16. Carlan SJ, O'Brien WF, O'Leary TD, et al: Randomized comparative trial of indomethacin and sulindac for the treatment of refractory preterm labor. Obstet Gynecol 79:223-228, 1992
17. Sugimoto Y, Yamasaki A, Segi E, et al: Failure of parturition in mice lacking the prostaglandin F receptor. Science 277:681-683, 1997
18. Coleman RA, Smith WL, Narumiya S: International union of pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46:205-229, 1994
19. Abramovitz M, Adam M, Boie Y, et al: The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483:285-293, 2000
20. Chemtob S, Peri K: THG113. BioContact Meeting, Québec, 2000
21. 2 receptors. Proc Natl Acad Sci USA 95:15792-15797, 1998
22. Abran D, Varma DR, Chemtob S, et al: Reduced responses of retinal vessels of the newborn pig to prostaglandins but not to thromboxane. Can J Physiol Pharmacol 72:168-173, 1994
23. Abran D, Varma DR, Chemtob S: Increased thromboxane-mediated contractions of retinal vessels of newborn pigs to peroxides. Am J Physiol 268:H628-H632, 1995
24. Abran D, Varma DR, Chemtob S: Regulation of prostanoid vasomotor effects and receptors in choroidal vessels of newborn pigs. Am J Physiol 272:R995-R1001, 1997
25. Chemtob S, Aranda JV, Varma DR: Effects of prostaglandins on isolated internal carotid and basilar arteries from newborn and adult pigs. Pediatr Rev Commun 4:101-109, 1989
26. Chemtob S, Inayatulla A, Varma DR: Eicosanoid-dependent and endothelium-independent oscillations of rat aorta. J Vasc Res 29:270-280, 1992
27. Varma DR, Chemtob S: Endothelium- and beta-2 adrenoceptor-independent relaxation of rat aorta by tyramine and certain other phenylethylamines. J Pharmacol Exp Ther 265:1096-1104, 1993
28. Romero R, Roslansky P, Oyarzun E, et al: Labor and infection. II. Bacterial endotoxin in amniotic fluid and its relationship to the onset of preterm labor. Am J Obstet Gynecol 158:1044-1049, 1988
29. Romero R, Sirtori M, Oyarzun E, et al: Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 161: 817-824, 1989
30. Narumiya S, Sugimoto Y, Ushikubi F, et al: Prostanoid receptors: structures, properties, and functions. Physiol Rev 79:1193-1226, 1999
31. Soloff MS: Cellular and integrative mechanisms, in Mc-Nellis D, Challis J, MacDonald P, Nathanielsz P, Roberts J (eds): The onset of labor. Ithaca NY, Perinatology Press, 1988, pp 87-123
32. Tulchinsky D, Hobel CJ, Yeager E, et al: Plama estradiol, estriol, and progesterone in human pregnancy. II. Clinical applications in Rh-isoimmunization disease. Am J Obstet Gynecol 113:766-770, 1972
33. Fang X, Wong S, Mitchell BF: Effects of RU486 on estrogen, progesterone, oxytocin, and their receptors in the rat uterus during late gestation. Endocrinology 138: 2763-2768, 1997
34. Kimura T, Ogita K, Kusui C: What knockout mice can tell us about parturition. Rev Reprod 4:73-80, 1999
35. Ou CW, Chen ZQ, Qi S, Expression and regulation of the messenger ribonucleic acid encoding the prostaglandin F(2alpha) receptor in the rat myometrium during pregnancy and labor. Am J Obstet Gynecol 182:919-925, 2000
36. Gross G, Imamura T, Vogt SK, et al: Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse. Am J Physiol 278;R1453-R1459, 2000
37. Smith GS, Baguma-Nibasheka M, Wu WX, et al: Regional variations in contractile responses to prostaglandins and prostanoid receptor messenger ribonucleic acid in pregnant baboon uterus. Am J Obstet Gyn 179:1545-1552, 1998
38. Morales WJ, Smith SG, Angel JL, et al: Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor: A randomized study. Obstet Gynecol 74: 567-572, 1989
39. Takahashi Y, Roman C, Chemtob S, et al: Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo. Am J Physiol 278:R1496-R1505, 2000
40. Norton ME, Merrill J, Cooper BA, et al: Neonatal complications after the administration of indomethacin for preterm labor. N Engl J Med 329:1602-1607, 1993