Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5′-monophosphate dehydrogenase inhibitor

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 3, 2002, Pages 1272-1277

  Jain, Jugnu ^a   Almquist, Susan J ^a   Heiser, Angela D ^a   Shlyakhter, Dina ^a   Leon, Eduardo ^a   Memmott, Christine ^a   Moody, Cameron Stuver ^a   Nimmesgern, Elmar ^a   Decker, Caroline ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; MERIMEPODIB; MIZORIBINE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RIBAVIRIN; UNCLASSIFIED DRUG; VX 148;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN TRANSPLANTATION; T LYMPHOCYTE;

ANIMALS; CELL DIVISION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FEMALE; HEMOLYTIC PLAQUE TECHNIQUE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IMP DEHYDROGENASE; INDICATORS AND REAGENTS; ISOENZYMES; MALE; MICE; MICE, INBRED BALB C; MITOGENS; PHENYLUREA COMPOUNDS; SKIN TRANSPLANTATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SPLEEN; T-LYMPHOCYTES;

EID: 0036720880     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.035659     Document Type: Article

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