Exploiting subsite S1 of trypsin-like serine proteases for selectivity: Potent and selective inhibitors of urokinase-type plasminogen activator

Journal of Medicinal Chemistry

Volumn 44, Issue 23, 2001, Pages 3856-3871

  Mackman, R L ^a   Katz, B A ^a   Breitenbucher, J G ^b   Hui, H C ^a   Verner, E ^a   Luong, C ^a   Liu, L ^c   Sprengeler, P A ^a  

^a Axys Pharmaceuticals Inc   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c Department of Preclinical Sciences ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 HYDROXYBIPHENYL 3 YL) 1H INDOLE 5 CARBOXAMIDINE; 5 AMIDINOINDOLE; ALANINE; CHLORINE; INDOLE DERIVATIVE; NITROGEN; PLASMINOGEN ACTIVATOR INHIBITOR; SERINE HYDROXYL OXYGEN; SERINE PROTEINASE; THROMBIN INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG; WATER;

ARTICLE; ATOM; BINDING AFFINITY; CRYSTALLOGRAPHY; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR WEIGHT;

AMIDINES; AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; INDOLES; MALE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY PLASMINOGEN ACTIVATOR; WATER;

EID: 0035829469     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010244+     Document Type: Article

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