Synthesis and preliminary biological evaluation of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 24, 2008, Pages 10165-10171

  Zhang, Jin Hua ^a   Fan, Chuan Dong ^a   Zhao, Bao Xiang ^a   Shin, Dong Soo ^b   Dong, Wen Liang ^c   Xie, Yong Sheng ^a   Miao, Jun Ying ^a  

^a SHANDONG UNIVERSITY   (China)

^b Changwon National University   (South Korea)

^c SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

A549 cells; Microwave assisted synthesis; Pyrazinone; Pyrazole; Single crystal

Indexed keywords

2 (4 CHLOROPHENYL) 5 [(6 CHLOROPYRIDIN 3 YL)METHYL] 6,7 DIHYDROPYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 2 (4 CHLOROPHENYL) 5 ISOPROPYL 6,7 DIHYDROPYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 5 (3,4 DIMETHOXYPHENETHYL) 2 PHENYL 6,7 DIHYDROPYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 5 BENZYL 2 (4 CHLOROPHENYL) 6,7 DIHYDROPYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; AMINE; CARBOXYLIC ACID DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRAZINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; HEATING; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MICROWAVE IRRADIATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DNA DAMAGE; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MOLECULAR STRUCTURE; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56349098902     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.066     Document Type: Article

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