5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 20, 2008, Pages 9093-9100

  Pan, Xiao Hong ^a,c   Liu, Xia ^a   Zhao, Bao Xiang ^a   Xie, Yong Sheng ^a   Shin, Dong Soo ^b   Zhang, Shang Li ^a   Zhao, Jing ^a   Miao, Jun Ying ^a  

^a SHANDONG UNIVERSITY   (China)

^b Changwon National University   (South Korea)

^c BINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

A549 cell; Apoptosis; Ferrocene; Integrin 4; Pyrazole fused pyrazinone; ROS

Indexed keywords

2 FERROCENYL 6,7 DIHYDROPYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE DERIVATIVE; BETA4 INTEGRIN; FERROCENE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG CANCER; NICK END LABELING; OXIDATIVE STRESS; PROTEIN EXPRESSION; REACTION ANALYSIS;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FERROUS COMPOUNDS; HUMANS; INTEGRIN BETA4; LUNG NEOPLASMS; MOLECULAR STRUCTURE; PYRAZINES; PYRAZOLES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53249134365     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.046     Document Type: Article

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