New pyrazoles incorporating pyrazolylpyrazole moiety: Synthesis, anti-HCV and antitumor activity

European Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2010, Pages 1042-1050

  Riyadh, Sayed M ^a   Farghaly, Thoraya A ^a   Abdallah, Magda A ^a   Abdalla, Mohamed M ^b   Abd El Aziz, Mohamed R ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b MAPCO Pharmaceuticals Ltd   (Egypt)

Author keywords

Anti HCV; Antitumor activity; Enaminones; Hydrazonoyl chlorides; Pyrazolylpyrazole derivatives; Subacute Sclerosing Panencephalitis (SSPE)

Indexed keywords

1 (4 BENZOYL 1 PHENYL 1H PYRAZOL 3 YL) 3 DIMETHYLAMINO PROPENONE; 1 (4 BENZOYL 1 PHENYL 1H PYRAZOL 3 YL)ETHANONE; 1 [4 (4 BENZOYL 1 PHENYL 1H PYRAZOLE 3 CARBONYL) 1 PHENYL 1H PYRAZOL 3 YL] 3 DIMETHYLAMINO PROPENONE; 1 [4 (4 BENZOYL 1 PHENYL 1H PYRAZOLE 3 CARBONYL) 1 PHENYL 1H PYRAZOL 3 YL]ETHANONE; 1 [4 [4 (4 BENZOYL 1 PHENYL 1H PYRAZOLE 3 CARBONYL) 1 PHENYL 1H PYRAZOLE 3 CARBONYL] 1 PHENYL 1H PYRAZOL 3 YL]ETHANONE; 1 [4 [4 [4 BENZOYL 1 (4 CHLOROPHENYL) 1H PYRAZOLE 3 CARBONYL] 1 PHENYL 1H PYRAZOL 3 YL]ETHANONE; 1 [4 [4 [4 BENZOYL 1 (4 NITROPHENYL) 1H PYRAZOLE 3 CARBONYL] 1 PHENYL 1H PYRAZOLE 3 CARBONYL] 1 PHENYL 1H PYRAZOL 3 YL]ETHANONE; 1 [4 [4 BENZOYL 1 (4 CHLOROPHENYL) 1H PYRAZOLE 3 CARBONYL] 1 PHENYL 1H PYRAZOL 3 YL]ETHANONE; 1 [4 [4 BENZOYL 1 (4 METHYLPHENYL) 1H PYRAZOLE 3 CARBONYL] 1 PHENYL 1H PYRAZOL 3 YL]ETHANONE; 1 [4 [4 BENZOYL 1 (4 NITROPHENYL) 1H PYRAZOLE 3 CARBONYL] 1 PHENYL 1H PYRAZOL 3 YL]ETHANONE; 1 [4 BENZOYL 1 (4 CHLOROPHENYL) 1H PYRAZOL 3 YL]ETHANONE; 1 [4 BENZOYL 1 (4 METHYLPHENYL) 1H PYRAZOL 3 YL] 3 DIMETHYLAMINO PROPENONE; 1 [4 BENZOYL 1 (4 METHYLPHENYL) 1H PYRAZOL 3 YL]ETHANONE; 1 [4 BENZOYL 1 (4 NITROPHENYL) 1H PYRAZOL 3 YL] 3 DIMETHYLAMINO PROPENONE; 1 [4 BENZOYL 1 (4 NITROPHENYL) 1H PYRAZOL 3 YL]ETHANONE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ANTIVIRUS AGENT; ASCORBIC ACID; CISPLATIN; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; PYRAZOLE DERIVATIVE; RIBAVIRIN; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER INHIBITION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MOUSE; NITRATION; NONHUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; SUBACUTE SCLEROSING PANENCEPHALITIS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONIC NEOPLASMS; CRICETINAE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HEPACIVIRUS; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PYRAZOLES; SUBACUTE SCLEROSING PANENCEPHALITIS;

EID: 75849131926     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.050     Document Type: Article

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