Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2010, Pages 210-218

  Xie, Yong Sheng ^a   Zhao, Hong Ling ^a   Su, Hua ^a   Zhao, Bao Xiang ^a   Liu, Jin Ting ^a   Li, Ji Kun ^b   Lv, Hong Shui ^a   Wang, Bai Shan ^a   Shin, Dong Soo ^c   Miao, Jun Ying ^a  

^a SHANDONG UNIVERSITY   (China)

^b TAISHAN UNIVERSITY   (China)

^c Changwon National University   (South Korea)

Author keywords

A549 lung cancer cell; Ferrocene; Pyrazole fused pyrazinone; Synthesis; X ray structure

Indexed keywords

2 FERROCENYL 5 (3 METHOXYPHENETHYL) 6 (4 METHOXYPHENYL)PYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 2 FERROCENYL 5 (3 METHOXYPHENETHYL) 6 PHENYLPYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 2 FERROCENYL 5 [2 (2 METHOXYPHENOXY)ETHYL] 6 (4 METHOXYPHENYL)PYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 2 FERROCENYL 5 [2 (2 METHOXYPHENOXY)ETHYL] 6 PHENYLPYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 5 (3,4 DIMETHOXYPHENETHYL) 2 FERROCENYL 6 (4 METHOXYPHENYL)PYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 5 (3,4 DIMETHOXYPHENETHYL) 2 FERROCENYL 6 PHENYLPYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 6 (4 CHLOROPHENYL) 2 FERROCENYL 5 (3 METHOXYPHENETHYL)PYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 6 (4 CHLOROPHENYL) 2 FERROCENYL 5 (3,4 DIMETHOXYPHENETHYL)PYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; 6 (4 CHLOROPHENYL) 2 FERROCENYL 5 [2 (2 METHOXYPHENOXY)ETHYL]PYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE; ANTINEOPLASTIC AGENT; FERROCENYL PYRAZOLO[1,5 A]PYRAZIN 4(5H) ONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL STRUCTURE; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; INFRARED RADIATION; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRAZINES;

EID: 72049098462     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.09.046     Document Type: Article

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