Identification of the first low-molecular-weight inhibitors of matriptase-2

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5523-5535

  Sisay, Mihiret Tekeste ^a   Steinmetzer, Torsten ^b   Stirnberg, Marit ^a   Maurer, Eva ^a   Hammami, Maya ^b   Bajorath, Jürgen ^a   Gütschow, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLSULFONYL DEXTRO ARGININYLPROLINE (4 AMIDINOBENZYL)AMIDE BIS(TRIFLUOROACETATE); BENZYLSULFONYL DEXTRO ARGININYLPROLINE TRIFLUOROACETATE; BENZYLSULFONYL DEXTRO ARGINYLPROLINE (2 AMINOMETHYL 5 CHLOROBENZYL)AMIDE BIS(TRIFLUOROACETATE); BENZYLSULFONYL DEXTRO CYCLOHEXYLALANINE; BENZYLSULFONYL DEXTRO CYCLOHEXYLALANYLPROLINE; BENZYLSULFONYL DEXTRO CYCLOHEXYLALANYLPROLINE (2 AMINOMETHYL 5 CHLOROBENZYL)AMIDE TRIFLUOROACETATE; BENZYLSULFONYL DEXTRO CYCLOHEXYLALANYLPROLINE (4 AMIDINOBENZYL)AMIDE TRIFLUOROACETATE; BENZYLSULFONYL N OMEGA NITRO DEXTRO ARGININE; ENZYME INHIBITOR; HEPCIDIN; MATRIPTASE; MATRIPTASE 2; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME INHIBITION; GENETIC TRANSFECTION; HEMOCHROMATOSIS; HUMAN; HUMAN CELL; IRON OVERLOAD; PROTEIN EXPRESSION; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BENZAMIDINES; CATALYTIC DOMAIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; SERINE ENDOPEPTIDASES; SULFONAMIDES;

EID: 77955383425     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100183e     Document Type: Article

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