Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans

Biochemical Journal

Volumn 400, Issue 3, 2006, Pages 551-561

  Okumura, Yuushi ^a   Hayama, Masaki ^a,b   Takahashi, Etsuhisa ^a   Fujiuchi, Mieko ^a   Shimabukuro, Aki ^a   Yano, Mihiro ^a   Kido, Hiroshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Glycosaminoglycan; Pericellular proteolysis; Polyserase 1; Pro urokinase plasminogen activation system; Serase 1B; TTSP (type II transmembrane serine protease)

Indexed keywords

AMINO ACIDS; BLOOD; CHEMICAL ACTIVATION; ENZYME INHIBITION; TISSUE; TUMORS;

GLYCOSAMINOGLYCAN; PERICELLULAR PROTEOLYSIS; PLASMINOGEN-ACTIVATION SYSTEMS; POLYSERASE-1; PRO-UROKINASE; SERASE-1B; TYPE II TRANSMEMBRANE SERINE PROTEASE (TTSP);

ENZYMES;

ALPHA 1 ANTIPLASMIN; ANTIPLASMIN; APROTININ; ENZYME VARIANT; GLYCOSAMINOGLYCAN; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYSERINE PROTEASE 1; PROTEIN C; RECOMBINANT PROTEIN; SERASE 1B; SERINE PROTEINASE; TRANSMEMBRANE SERINE PROTEASE 9; TRYPSIN; UROKINASE RECEPTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZYMOGRAPHY;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; GLYCOSAMINOGLYCANS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROTEIN ISOFORMS; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; URINARY PLASMINOGEN ACTIVATOR;

ECHINOIDEA;

EID: 33845807406     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060212     Document Type: Article

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