Synthesis, fluorine-18 radiolabeling, and biological evaluation of N -((E)-4-fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4?-halophenyl) nortropanes: Candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5549-5557

  Stehouwer, Jeffrey S ^a   Daniel, Lauryn M ^a   Chen, Ping ^a   Voll, Ronald J ^a   Williams, Larry ^a   Plott, Susan J ^a   Votaw, John R ^a   Owens, Michael J ^a   Howell, Leonard ^a,b   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE TRANSPORTER; FLUORINE 18; N (4 FLUOROBUT 2 EN 1 YL) 2BETA CARBOMETHOXY 3BETA (4' HALOPHENYL)NORTROPANE; NORADRENALIN TRANSPORTER; RADIOLIGAND; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; IMAGING; IN VIVO IMAGING; ISOTOPE LABELING; NONHUMAN; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; PUTAMEN; RADIOCHEMISTRY; RHESUS MONKEY;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CAUDATE NUCLEUS; CEREBELLUM; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FLUORINE RADIOISOTOPES; HUMANS; LIGANDS; MACACA FASCICULARIS; NORTROPANES; POSITRON-EMISSION TOMOGRAPHY; PUTAMEN; RADIOPHARMACEUTICALS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955357683     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100269c     Document Type: Article

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