Gαq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Gαq mediated hypertrophy

Journal of Molecular and Cellular Cardiology

Volumn 40, Issue 5, 2006, Pages 597-604

  Howes, Amy L ^a   Miyamoto, Shigeki ^b   Adams, John W ^a   Woodcock, Elizabeth A ^b   Brown, Joan Heller ^c  

^a ARENA PHARMACEUTICALS   (United States)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiac myocyte; EGFR; G q; Hypertrophy; Survival

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; DEOXYGLUCOSE; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; ENZYME INHIBITOR; TYRPHOSTIN;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SIZE; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; VIRUS INFECTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; HEART MUSCLE; HEART VENTRICLE; HYPERTROPHY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TRANSACTIVATION;

ADENOVIRIDAE; ANIMALIA; CANIS FAMILIARIS;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; ENZYME INHIBITORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEART VENTRICLES; HYPERTROPHY; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANS-ACTIVATION (GENETICS); TYRPHOSTINS;

EID: 33646093022     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2005.12.003     Document Type: Article

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